Einfluβ von l-β-D-Ribofuranosyl-1,2,4-triazol-3-carboxamid (Virazol) auf die Bildung und Konzentration von Tabakmosaikvirus- und Wirts-RNA sowie auf Wirtsproteine

Mode of Action of the Antiphytoviral Compound 2,4-Dioxohexahydro-1,3,5-triazine (5-Azadihydrouracil)

“…into tobacco mosaic virus (TM V) RN A, espe cially during the phase of rapid virus multi plication. The content of TMV RNA was considerably reduced, whereas there were less noticeable effects of DHT on the synthe sis and content of host RNA [4], These results are similar to those obtained with the pyrimi dine base analogue 2-thiouracil (2-TU) [5,6] or with ribavirin, an analogue of an anabolite of purine bases [7]. Moreover, after applica tion of 6-'4C-DHT, some radioactivity is in corporated into both virus RNA and host plant RNA, the activity of TMV RNA being about twice that of host RNA [8].…”

On Virus-Induced Virus Inhibitors from Locally TMV-Infected Plants of Nicotiana glutinosa L.

“…Three hours later leaves of N. glutinosa were inoculated with the crude extracts. The TMV necessary for these experiments was purified using a polyethylene glycol method described by VENEKAMP et al (1964) and modified by BYHAN et al (1978).…”

“…Three hours later leaves of N. glutinosa were inoculated with the crude extracts. The TMV necessary for these experiments was purified using a polyethylene glycol method described by VENEKAMP et al (1964) and modified by BYHAN et al (1978).To determine the in-vivo activity of virus-induced virus inhibitors, plants of N. tabacum L. 'Samsun' were treated with clarified juices from N. glutinosa leaves in which the antiviral principle (AVP) had been induced. This treatment was carried out 48, 24, and 12 h before inoculation.…”