Einfluß der Chelatbildner auf die Ausscheidung des Cadmiums bei Cadmiumvergiftung

Eybl, V.; Sýkora, J.; Mertl, F

doi:10.1007/bf00246433

Cited by 22 publications

(2 citation statements)

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“…The problem in cadmium chelation is the special toxicokinetics of cadmium, which, after systemic entrance, is rapidly localized intracellularly, mainly in the liver, then bound to metallothionein (MT), and subsequently slowly transferred as the MT complex via blood to be deposited in proximal tubular cells in the kidney. This is the background for the toxicity of chronic cadmium exposure leading to urinary loss of filtrable proteins, calcium, and other small molecules, which may in turn lead to development of osteomalacia, 162 and also for the rapid decline in efficacy of treatment of acute cadmium intoxication with hydrophilic chelators demonstrated by Eybl et al 163 and confirmed several years later by Cantilena and Claassen. 164 Effects of a large number of chelating agents belonging to several chemical compound groups have been investigated.…”

Section: F Cadmiummentioning

confidence: 96%

Principles and Recent Developments in Chelation Treatment of Metal Intoxication

1999

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Section: F Cadmiummentioning

confidence: 96%

Principles and Recent Developments in Chelation Treatment of Metal Intoxication

1999

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“…Table 12 Acronyms and IUPAC names of chelating agents for Cd(II) intoxication. The use of lipophilic chelators was found to increase cadmium toxicity in rabbits [174], but studies of hydrophilic chelators such as DMSA and DTPA, as well as polyaminopolycarboxylic acids, showed that these molecules were effective in both increasing cadmium excretion and reducing its toxicity [175][176][177][178][179].…”

Section: Recent Developments In Chelation Therapy For Cadmiummentioning

confidence: 99%

Competition between Cd(II) and other divalent transition metal ions during complex formation with amino acids, peptides, and chelating agents

Remelli

Nurchi

Lachowicz

et al. 2016

Coordination Chemistry Reviews

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Lanthanide‐Ion Complexation by D‐Glucuronic and D‐Galacturonic Acids

Fuks¹,

Bünzli

1993

Helvetica Chimica Acta

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To assess the potential of naturally occurring substances in the treatment of heavy-metal intoxication, the interaction between D-galacturonic and ~-glucuronic acids with several trivalent lanthanide ions has been studied in aqueous solutions by means of a spectrophotometric method (27"; 0 . 1~ NaC10,; pH 4.0). Values for the overall stability constants for [LnL] and [LnL,] (Ln = La, Ce, Pr, Nd, Gd, or Lu) complexes are presented and discussed.The interpretation of the data shows that, similarly to acetates, the COOH group coordinates metal ions in both [LnL] and [LnL,] complexes. The 1 :I complexation is supplemented by the ring C(5)-0-atom. Moreover, the C(4)-0-atom seems to play an important role in the steric hindrance of the chelating ligand molecules.Introduction. -Lanthanide ions are found in living organisms in trace amounts only, and they are considered to play no biological role 111. They interact, however, with biological materials in specific ways, which along with their unique magnetic and spectroscopic properties make them very informative substitution probes for Ca-, Mg-or Zn-containing biological materials [2]. Because of their chemical similarity, lanthanides may also act as substitution probes for the actinides, especially for those radioactive elements available only in submicroquantities.Foreign chemicals entering into the organism are usually converted into compounds that can be excreted. For heavy metals deposited into the organism, there is no physiological process that will eliminate them rapidly from the body. Their excretion rate is so slow that, in a normal life span, only a fraction of the deposited metals can be removed from the body. Events such as the Chernobyl fallout have stimulated studies leading to the development of new therapeutic methods for the removal of immobilized radioactive materials. The strategy for this removal has been mainly based on the use of high-affinity chelating agents which migrate preferentially to certain organs in vivo. A toxic metal bound to a constituent of living organisms (usually a protein) is transformed into a metal chelate which is readily excreted. It has long been known that the increase in stability constant of a metal complex parallels an increase in excretion rate [3-51.The majority of artificial chelating agents that are commerically available have been developed for purposes other than the removal of toxic metal ions from mammalian body. The most popular chelating agents EDTA (ethylenediaminetetraacetic acid) and DTPA (diethylenetriaminepentaacetic acid) have several COOH groups which are ionized under physiological conditions. Therefore, they cannot pass through cell membranes to any significant extent [6] [7]. As a result, EDTA and DTPA are very effective in

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Einfluß der Chelatbildner auf die Ausscheidung des Cadmiums bei Cadmiumvergiftung

Cited by 22 publications

References 2 publications

Principles and Recent Developments in Chelation Treatment of Metal Intoxication

Principles and Recent Developments in Chelation Treatment of Metal Intoxication

Competition between Cd(II) and other divalent transition metal ions during complex formation with amino acids, peptides, and chelating agents

Lanthanide‐Ion Complexation by D‐Glucuronic and D‐Galacturonic Acids

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