Einflu� von Natriumselenit, Natriumtellurit und Natriumsulfit auf Retention und Verteilung von Quecksilber bei M�usen

Eybl, V.; Skóra, Justyna; Mertl, F

doi:10.1007/bf00577783

Cited by 28 publications

(5 citation statements)

References 8 publications

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“…Administration of Se compounds did not increase Hg excretion, but on the contrary markedly increased the Research level of Hg in the blood. Whole body retention of Hg was also increased by Se (Eybl et al, 1969). Whole body retention of Hg was also increased by Se (Eybl et al, 1969).…”

mentioning

confidence: 88%

“…The magnitude of the increase depended on the dose of Se. These facts led to the conclusion that the administration of Se compounds not only increased the retention of Hg but also changed its distribution within the body (Parizek et al, 1969(Parizek et al, , 1971and Eybl et al, 1969). These facts led to the conclusion that the administration of Se compounds not only increased the retention of Hg but also changed its distribution within the body (Parizek et al, 1969(Parizek et al, , 1971and Eybl et al, 1969).…”

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confidence: 99%

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A Mutual Protective Effect of Mercury and Selenium in Japanese Quail

1977

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Dietary interactions between methylmercury (Ch3Hg) and sodium selenite (Na2SeO3) were studied in Japanese quail. Addition of 0.35-6 p.p.m. Se to diets containing toxic levels of Hg (5-30 p.p.m. Hg) reduced the toxicity of methylmercury and increased the survival of Japanese quail. The survival increased with increasing levels of Se in the diet. Selenium as 6 p.p.m. did not cause any mortality in males and caused only relatively low mortality in females. However, 12 p.p.m. Se depressed the survival of quail, especially females. No consistent effect of Hg, Se or both was observed on body weight or feed consumption. High levels of Hg reduced egg production, fertility and hatchability, and the addition of Se lessened these effects of Hg. Selenium in the diet alone (6 or 12 p.p.m.) generally produced lower hatchability and a high percentage of deformed embryos, and 12 p.p.m. Se also depressed egg production. Addition of 5-15 p.p.m. Hg to such Se diets overcame these effects and reduced the percentage of abnormal embryos more than 50%. Analysis of tissues for total Hg showed that Hg was distributed in a pattern typical for alkyl mercurials. Hg levels in Se-protected birds equaled or exceeded the levels in those fed Hg without Se. Se levels in tissues were generally elevated by feeding Hg, especially in brain. Extremely high brain Hg levels, up to 58 p.p.m., were observed in birds fed 15 p.p.m. Hg plus 6 p.p.m. Se for 20 weeks prior to sacrifice. The levels of Se in the brain of these birds was elevated (4 p.p.m.), but not equimolar to Hg.

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confidence: 88%

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confidence: 99%

A Mutual Protective Effect of Mercury and Selenium in Japanese Quail

1977

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“…The protective action of sodium selenite against the nephrotoxic effect of inorganic mercury (13,(28)(29)(30)(31)(32)(33)(34) and the beneficial action of selenium in methylmercury poisoning has been described by many authors (33,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). Sodium selenite administration results in delayed occurrence of symptoms of neurological and histological disturbances and in enhanced life expectancy of exposed animals (40,43,48).…”

Section: Introductionmentioning

confidence: 99%

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Brzeznicka¹,

Chmielnicka²

1985

Environmental Health Perspectives

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“…Thus uptake of Hg2+ by the liver is increased by selenium and in the first 24 hr is unaffected by tellurium, whereas uptake by the kidney is decreased by selenium and increased by tellurium (6). The difference in these effects might be explained by the higher reduction potential of SeO32 compared with that of TeO32.…”

Section: Reaction Between Two Metalsmentioning

confidence: 95%

Theoretical and Practical Considerations on the Problem of Metal. Metal Interaction

Magos¹,

Webb²

1978

Environmental Health Perspectives

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The interaction between two metals, which can be either synergistic or antagonistic, implies that the behavior of one is changed by the presence of the other. Possible mechanisms of these interactions, whkh include chemical association, competition for carriers, metabolic changes, induction of binding proteins, membrane alterations are discussed.The interactions between toxic compounds is a loose term which implies that the behavior or effect of one compound is changed by the administration or presence of another. It does not imply that the two compounds interact chemically, although chemical reaction between them or their metabolites is possible. Studies on the interaction between metals are only in an early phase and do not permit the development of generalizations or classifications.

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Einflu� von Natriumselenit, Natriumtellurit und Natriumsulfit auf Retention und Verteilung von Quecksilber bei M�usen

Cited by 28 publications

References 8 publications

A Mutual Protective Effect of Mercury and Selenium in Japanese Quail

A Mutual Protective Effect of Mercury and Selenium in Japanese Quail

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Theoretical and Practical Considerations on the Problem of Metal. Metal Interaction

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