Eine Normierungsstudie eines modifizierten Trail Making Tests im deutschsprachigen Raum

Rodewald, Katlehn; Bartolovic, Marina; Debelak, Rudolf; Aschenbrenner, Steffen; Weisbrod, Matthias; Roesch-Ely, Daniela

doi:10.1024/1016-264x/a000060

Cited by 51 publications

(51 citation statements)

References 61 publications

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“…Out of a larger pool of neuropsychological tests within the RIMCAD-study (for a comprehensive description see Conwell et al, 2018), we selected the Verbal Learning and Memory Test (VLMT), a German version of the Rey Auditory Verbal Learning Test (RAVLT) (Lux et al, 1999) as a test of memory performance (Zhao et al, 2015), and The Trail Making Test (TMT) (Rodewald et al, 2012) as an indicator of cognitive flexibility (Kinsella et al, 2007).…”

Section: Neuropsychological Testsmentioning

confidence: 99%

Graph Theory Analysis Reveals Resting-State Compensatory Mechanisms in Healthy Aging and Prodromal Alzheimer’s Disease

Behfar

Reutern

et al. 2020

Front. Aging Neurosci.

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Several theories of cognitive compensation have been suggested to explain sustained cognitive abilities in healthy brain aging and early neurodegenerative processes. The growing number of studies investigating various aspects of task-based compensation in these conditions is contrasted by the shortage of data about resting-state compensatory mechanisms. Using our proposed criterion-based framework for compensation, we investigated 45 participants in three groups: (i) patients with mild cognitive impairment (MCI) and positive biomarkers indicative of Alzheimer's disease (AD); (ii) cognitively normal young adults; (iii) cognitively normal older adults. To increase reliability, three sessions of resting-state functional magnetic resonance imaging for each participant were performed on different days (135 scans in total). To elucidate the dimensions and dynamics of resting-state compensatory mechanisms, we used graph theory analysis along with volumetric analysis. Graph theory analysis was applied based on the Brainnetome atlas, which provides a connectivity-based parcellation framework. Comprehensive neuropsychological examinations including the Rey Auditory Verbal Learning Test (RAVLT) and the Trail Making Test (TMT) were performed, to relate graph measures of compensatory nodes to cognition. To avoid false-positive findings, results were corrected for multiple comparisons. First, we observed an increase of degree centrality in cognition related brain regions of the middle frontal gyrus, precentral gyrus and superior parietal lobe despite local atrophy in MCI and healthy aging, indicating a resting-state connectivity increase with positive biomarkers. When relating the degree centrality measures to cognitive performance, we observed that greater connectivity led to better RAVLT and TMT scores in MCI and, hence, might constitute a compensatory mechanism. The detection and improved understanding of the compensatory dynamics in healthy aging and prodromal AD is mandatory for implementing and tailoring preventive interventions aiming at preserved overall cognitive functioning and delayed clinical onset of dementia.

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Section: Neuropsychological Testsmentioning

confidence: 99%

Graph Theory Analysis Reveals Resting-State Compensatory Mechanisms in Healthy Aging and Prodromal Alzheimer’s Disease

Behfar

Reutern

et al. 2020

Front. Aging Neurosci.

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“…The time participants require for completing TMT part B has been reported as valid measure of executive functioning subdomain set-shifting [ 71 ] and will be used for analyses. In the present study, the Langensteinbacher version of the TMT (TMT-L) [ 72 ] will be applied. It will be operated via the Wiener Test-System (WTS) (Schuhfried, Vienna, Austria) and adequate psychometric properties have been reported for it [ 72 ].…”

Section: Methodsmentioning

confidence: 99%

“…In the present study, the Langensteinbacher version of the TMT (TMT-L) [ 72 ] will be applied. It will be operated via the Wiener Test-System (WTS) (Schuhfried, Vienna, Austria) and adequate psychometric properties have been reported for it [ 72 ]. TMT-L parallel versions S1, S2 and S3 will be used in a random order at the 3 measurement time-points, but counterbalanced across participants.…”

Section: Methodsmentioning

confidence: 99%

Protocol for the “Chemobrain in Motion – study” (CIM – study): a randomized placebo-controlled trial of the impact of a high-intensity interval endurance training on cancer related cognitive impairments in women with breast cancer receiving first-line chemotherapy

et al. 2018

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BackgroundUp to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in breast cancer patients. Potentially underlying immunological and neurobiological mechanisms, as well as effects on patients’ self-perceived cognitive functioning and common cancer related side-effects, will be explored.MethodsA single-blinded randomized controlled trial will be carried out. The impact of HIIT on CRCI will be compared to that of a placebo-intervention (supervised myofascial release training). Both interventions will be conducted simultaneously with the patients’ first-line chemotherapy treatment typically lasting 12–18 weeks. Fifty-nine women with breast cancer will be included in each of the two groups. The study is powered to detect (α = .05, β = .2) a medium effect size difference between the two groups (d = .5) in terms of patients’ change in cognitive testing performances, from baseline until the end of the exercise-intervention. The cognitive test battery, recommended by the International Cancer and Cognition Task Force to assess CRCI, will be used as primary measure. This includes the Hopkins Verbal Learning Test (learning/verbal memory), the Controlled Oral Word Association Test (verbal fluency) and the Trail-Making-Test A/B (attention/set-switching). The following endpoints will be assessed as secondary measures: Go-/No-Go test performance (response inhibition), self-perceived cognitive functioning, serum levels of pro- and antiinflammatory markers (tumor necrosis factor alpha, Interleukin-6, Interleukin-1 alpha, Interleukin-1 beta, C-reactive protein, Interleukin-1 receptor antagonist and Interleukin-10), serum levels of neurotrophic and growth factors (brain-derived neurotrophic factor, insulin-like growth factor 1 and vascular endothelial growth factor), as well as common cancer-related side effects (decrease in physical capacity, fatigue, anxiety and depression, sleep disturbances, quality of life and chemotherapy compliance).DiscussionThis study will provide data on the question whether HIIT is an effective supportive therapy that alleviates CRCI in breast cancer patients. Moreover, the present study will help shed light on the underlying mechanisms of potential CRCI improving effects of exercise in breast cancer patients.Trial registrationDRKS.de, German Clinical Trials Register (DRKS), ID: DRKS00011390, Registered on 17 January 2018.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4992-3) contains supplementary material, which is available to authorized users.

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“…Secondary outcomes include per cent weight change from pre-treatment at 2 months (t1, post-treatment) and at 12-month follow-up (t3), derived from objectively measured body weight, in order to inform about treatment effects on early weight loss and on weight loss maintenance. Further, secondary outcomes consist of: executive functioning (t0, t1), as assessed through the Iowa Gambling Task, 67 Inhibition (Go/NoGo, StopSignal), 68 Delay Discounting Task, 69 Tower of London, 70 Wisconsin Card Sorting Test, 71 Trail Making Test 72 ; weight loss-related behaviours (t0–t3), including, self-efficacy (Generalised Self-Efficacy Scale), 73 74 eating behaviour (Dutch Eating Behaviour Questionnaire), 75 76 and physical activity (International Physical Activity Questionnaire) 77 ; attendance to BWL sessions and retention as measures of patients’ adherence to a weight loss regimen; mental health (t0–t3), operationalised as eating disorder psychopathology (Eating Disorder Examination-Questionnaire 8), 78 general psychopathology (Patient Health Questionnaire) 79 80 and quality of life (Impact of Weight on Quality of Life) 81 82 ; and physical health (t0–t3), for which hip and waist circumference, blood pressure, bioelectrical impedance, and triceps and subscapularis skinfolds are measured. We chose these outcome measures because they cover clinically relevant aspects, exhibit good psychometric properties and are well-established in the German language as well as commonly used in international research studies on obesity.…”

Section: Methods and Analysismentioning

confidence: 99%

Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study)

Hilbert

Blume

Petroff³

et al. 2018

BMJ Open

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IntroductionIndividuals with obesity show deficits in executive functioning which have been implicated in decreased weight loss outcome. Preliminary evidence suggests that cognitive remediation therapy (CRT) improves executive functioning and weight loss in obesity. However, confirmatory support, especially for pre-weight loss use, is lacking. The CRT study aims at determining the efficacy of CRT versus no treatment control in patients with obesity before entering behavioural weight loss (BWL) treatment. It is hypothesised that individuals who receive CRT will show better weight loss outcome, improved executive functioning, greater weight loss-related behavioural changes and higher attendance of BWL treatment, 6 and 12 months after cessation of CRT.Methods and analysisIn a single-centre, assessor-blinded, randomised, two-armed parallel-group superiority trial, 260 adults with body mass index ≥35.0 kg/m2 are centrally randomised to 8-week group-based CRT versus no treatment, before entering BWL treatment. Primary outcome is the amount of weight loss (%) at 6-month follow-up, compared with pre-treatment, derived from measured body weight. Secondary outcomes include improvement in executive functioning post-treatment and in weight loss-related behaviour, mental and physical health, and attendance to BWL treatment at 6-month and 12-month follow-up. Maintenance of weight loss at 12-month follow-up will be determined. Mixed model analyses based on intent-to-treat will be used to compare the CRT and control groups with respect to differences in weight change between pre-treatment and 6-month follow-up. Similar models will be used for analysing 12-month follow-up data and secondary outcomes. Further analyses will include additional covariates to identify predictors of treatment outcome.Ethics and disseminationThe study was approved by the Ethical Committee of the University of Leipzig (256-15-13072015, version ‘Final 1.0 from 28 May 2015). The study results will be disseminated through peer-reviewed publications.Trial registration numberDRKS00009333; Pre-results.

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Eine Normierungsstudie eines modifizierten Trail Making Tests im deutschsprachigen Raum

Cited by 51 publications

References 61 publications

Graph Theory Analysis Reveals Resting-State Compensatory Mechanisms in Healthy Aging and Prodromal Alzheimer’s Disease

Graph Theory Analysis Reveals Resting-State Compensatory Mechanisms in Healthy Aging and Prodromal Alzheimer’s Disease

Protocol for the “Chemobrain in Motion – study” (CIM – study): a randomized placebo-controlled trial of the impact of a high-intensity interval endurance training on cancer related cognitive impairments in women with breast cancer receiving first-line chemotherapy

Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study)

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