Eine einfache und zuverlässige gas-chromatographische Bestimmung von Ameisensäure im Urin

Triebig, Gerhard; Schaller, K. H.; Goßler, K.

doi:10.1007/bf00482277

Z. Anal. Chem.

1978

DOI: 10.1007/bf00482277

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Eine einfache und zuverlässige gas-chromatographische Bestimmung von Ameisensäure im Urin

Gerhard Triebig¹,

K. H. Schaller²,

K. Goßler³

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1980

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Cited by 3 publications

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“…Normal blood levels of formic acid in humans range from 0 to 12 mg/L (average 6 mg/L). Urine formic acid levels range from 0 to 27 mg/L (average 17-19 mg/L) [16,17]. Although absolute toxic levels are not known, Eells et al demonstrated that ingestion of 120 ml of 37% formaldehyde resulted in formic acid blood levels as high as 500 mg/L.…”

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confidence: 99%

Absorption Kinetics of Rectal Formalin Instillation

et al. 1997

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Formalin instillation has become an accepted treatment of radiation-induced hemorrhagic cystitis and proctitis since the initial report by Brown in 1969 (Med. J. Aust. 1:23, 1969). Although its use is widespread, no studies have been performed to determine the safest, volume or duration of formalin exposure. The purpose of our study was to determine the optimum technique for instillation and the safety margin regarding the maximum time that formalin can be in contact with the rectal mucosa without causing serum toxicity. In a pilot canine study, 4% neutral buffered formalin was instilled into the rectum in 30 ml aliquots for 60 seconds each after which each aliquot was withdrawn; a total volume of 400 ml was used. Our subsequent experiment involved rectal instillation of a single formalin bolus of 100 ml for 1 hour without removal during this time. Formalin metabolites were measured in the blood and urine to assess toxicity. Results indicate that with the latter technique serum formic acid reaches toxic levels within 15 minutes of instillation and may stay elevated for several hours. Metabolites in the urine similarly increase within 15 minutes, lagging only shortly behind the rise in serum levels. Performing formalin instillation in a series of 30 ml aliquots appears to be a safer treatment, as toxic serum levels were not reached and their slight rise above baseline returned to normal within 3 hours.

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Absorption Kinetics of Rectal Formalin Instillation

et al. 1997

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M�glichkeiten der analytischen Erfassung von Konservierungsstoffen in Lebensmitteln

Hild

Gertz

1980

Z Lebensm Unters Forch

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For the quantitative determination of preservatives in food, analyses were carried out by means of GLC, HPLC, and TLC according to the TAS-method. Using the alkaline extract (sample preparation see part I) the preservatives can be analysed as free acid or appropriate ester out the same GLC-column without any interference from coextractives. A fast and accurate HPLC determination can be achieved by direct injection of the alkaline extract. All preservatives were well separated and detected at a wavelength of 225 resp. 232 nm. As a quick test for the qualitative estimation the TLC (TAS) method is suggested and a suitable solvent system is proposed.

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A simple and reliable enzymatic assay for the determination of formic acid in urine

Triebig¹,

Schaller²

1980

Clinica Chimica Acta

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Eine einfache und zuverlässige gas-chromatographische Bestimmung von Ameisensäure im Urin

Cited by 3 publications

References 2 publications

Absorption Kinetics of Rectal Formalin Instillation

Absorption Kinetics of Rectal Formalin Instillation

M�glichkeiten der analytischen Erfassung von Konservierungsstoffen in Lebensmitteln

A simple and reliable enzymatic assay for the determination of formic acid in urine

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