Eine einfache Synthese von 4‐Oxazolin‐2‐on

Abstract

Fur das vorher unbekannte 4-Oxazolin-2-on (4) wird eine einfache Synthese ausgehend von 3-Acetyloxazolidin-2-011 (1) beschrieben. 1H-und 13C-NMR-Daten von 4 werden diskutiert. Facile Synthesis of 4-Oxazolin-2-oneA convenient synthesis of the previously unknown 4-oxazolin-2-one (4) starting'from 3-acetyloxazolidin-2-one (1) is described. 1H-and 13C-NMR data of 4 are reported.

Photochemistry of (o-methylphenyl)alkenes and the stereospecific trapping of the resulting o-xylylenes

“…butenes,2 Vollhardt's method based on the cobalt-catalyzed preparation of the benzocyclobutenes,25,3 various 1 ¿-eliminations,2b,<H,h'4 345and the photoenolization of o-alkylphenyl ketones. 5 Our interest in this area is the synthetic use of o-xylylenes generated photochemically from o-alkylstyrene derivatives. 6 We have recently demonstrated that several phenyl-substituted o-xylylenes generated by this method can be trapped as Diels-Alder adducts in good yields.…”

Rhodium-Catalyzed Decarboxylative Cycloaddition Route to Substituted Anilines

“…Dimethyl 2,2-di(but-2-yn-1-yl)malonate ( 1 ), methyl 2-(but-2-yn-1-yl)hex-4-ynoate ( 6 ), 5,5-di(but-2-yn-1-yl)-2,2-dimethyl-1,3-dioxane ( 12 ), 1-(but-2-yn-1-yloxy)but-2-yne ( 8 ), (((2,2-di(but-2-yn-1-yl)propane-1,3-diyl)bis(oxy))bis(methylene)]dibenzene ( 16 ), dimethyl 2,2-di(prop-2-yn-1-yl)malonate ( 18 ), dimethyl 2,2-bis(3-phenylprop-2-yn-1-yl)malonate ( 20 ), dimethyl 2,2-bis(4-methylpent-2-yn-1-yl)malonate ( 22 ), 2,2-di(but-2-yn-1-yl)malononitrile ( 24) , (nona-2,7-diyne-5,5-diyldisulfonyl)dibenzene ( 26 ), tetraethyl deca-2,8-diyne-5,5,6,6-tetracarboxylate ( 28 ), and tetraethyl octa-1,7-diyne-4,4,5,5-tetracarboxylate ( 30 ) were prepared according to literature procedures. 2-Oxazolone ( 4 ) and N -acetyl-2-oxazolone were prepared according to literature procedures …”

Studies on the Total Synthesis of Streptazolin and Its Related Natural Products: First Total Synthesis of (±)-8α-Hydroxystreptazolone

“…3-[(3 -tert -Butyldiphenylsiloxy)-4-heptynyl]-2-oxazolone (15). To a solution of 2-oxazolone (20.4 mg, 0.24 mmol) in dry DMF (3.0 mL) was added NaH (14.0 mg, 0.35 mmol) at 0 °C. After being stirred for 30 min, a solution of 14 (76.0 mg, 0.16 mmol) in DMF (2.0 mL) was added to the reaction mixture, which was stirred at room temperature for 12 h. The reaction mixture was quenched by addition of saturated aqueous NH 4 Cl and extracted with AcOEt.…”