Ein M�uschen f�r die Therapie

Ca, Sander; Wörle, Birgit; Plewig, Gerd

doi:10.1007/s001050050361

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Perfluorinated groups also provide handles for purification, mass spectrometry, and 19 F NMR studies in complex environments. , The growth of demand and the application field expansion of organofluorine compounds stimulate the investigation that aimed to develop the methods of their synthesis and separation/purification from reaction mixtures. , Usage of perfluorinated organic compounds in medicine specifies stringent requirements on their purity. However, the number of papers in the field of separation technology, perfluorocycloalkanes (PFCA) in particular, − is much less than the number of studies devoted to their synthesis ,− and application. − …”

Section: Introductionmentioning

confidence: 99%

“…The fluorination process at PFCA production can be carried out in the “mild” , (by cobalt(III) fluoride, e.g.) or “harsh” conditions − (by molecular fluorine) In the first case, the fluorination products contain a significant amount of partially fluorinated species . The latter are extremely toxic, and their content is strictly regulated in compounds used in medicine; In the second case, during fluorination under “harsh” conditions, almost complete substitution of H atoms for F atoms is achieved.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Perfluoro(7-methylbicyclo[4.3.0]nonane) and Perfluoro(butylcyclohexane): Physicochemical, Thermophysical, and Spectral Data

et al. 2023

View full text Add to dashboard Cite

New physicochemical data for perfluoro(7-methylbicyclo[4.3.0]nonane) and perfluoro(butylcyclohexane) with a purity ≥ 0.991 mass fraction are presented: the temperature and heat of the solid–liquid phase transition, the dependence of saturated vapor pressure, viscosity, density (liquid molar volume), and refractive index on temperature; the coefficients of the Antoine equation; 19F and 13C NMR and FTIR spectra; and gas chromatography–mass spectrometry data. For the perfluoro(7-methylbicyclo[4.3.0]nonane)–perfluoro(butylcyclohexane) binary system, the dependences are given: refractive index (at 15 °C) and density (at 20 °C) on the composition and boiling point on the composition in the pressure range from 20 kPa to atmospheric pressure. The average integral value of the relative volatility coefficient for various concentration ranges at atmospheric pressure is determined.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perfluoro(7-methylbicyclo[4.3.0]nonane) and Perfluoro(butylcyclohexane): Physicochemical, Thermophysical, and Spectral Data

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Arpin et al 32 developed a new model using a modified FAN method coupled with a finite-difference scheme for the calculation of 2-D flow inside a coat-hanger die. Other works 35,[37][38][39]47,48 using numerical methods have been reviewed in more detail elsewhere. 7 Nonisothermal flows in coat-hanger dies have been investigated in some studies.…”

Section: Methodsmentioning

confidence: 99%

A comprehensive 3‐D analysis of polymer melt flow in slit extrusion dies

2004

View full text Add to dashboard Cite

An understanding of flow behaviour of polymer melts through a slit die is extremely important for optimizing die design and, consequently, for die performance in processing polymer sheets and films. In view of the complex nature and the physical properties of polymer melts as well as of die geometries, such as coat-hanger dies, no simple mathematical formulae can be used to compute the flow regimes within dies. This paper illustrates the development of a three-dimensional (3-D) computer model of an example of a coat-hanger die design using the computational fluid dynamics package, FIDAP, based on the finite element method. A difference of only 3.7% was found when comparing the velocity distribution at the die exit obtained from the 3-D simulation with that calculated using a twodimensional analytical design procedure, indicating that full 3-D analysis seems to be unnecessary. However it has been shown that unwanted flow phenomena and production problems can be ameliorated by means of visualization and the detailed information obtained from computer simulations. Comparative simulation results with polymers of different rheological properties in the same die are also described. The comprehensive analyses provide a means of interpretation for flow behavior, which allows modification of the die geometry for optimal design.

show abstract

“…Dieses wird häufig mit Ciclosporin A und topisch anzuwendenden Klasse‐4‐Steroiden kombiniert. An der Mundschleimhaut werden die steroidhaltigen Externa am besten mit Hilfe einer speziellen Technik unter Anwendung von Mulltupfern appliziert [52]. Alternativ zu der topischen Anwendung von Steroiden hat sich der topische Einsatz von Tacrolimus Salbe sowohl an der Haut, wie auch an der Schleimhaut bewährt.…”

Section: Therapieunclassified