In the previous commlliunication (Sendrov and Sclhultz (1936)) evidence was presented inldicatiing that patients with active rheumiiatic fever utilize ascorbic acid in practicallv the same manner as do controls without active manifestations of this disease. Apparenit abnormalities in excretion of this vitamiin were attributable to gastrointestinal abn-iorm-nalities or to other conditions arising fromii the diseased state rather than to an essenitial deficienccv on the part of the tissues to hanidle this substance. As these patienits were all sufferin<, fromii rather severe active rheumiiatic inifection at the timiie of testing, it was thought that the possil)le relationship between rheumiiatic fever and ascorbic acid deficiency miiight be studied fromii two other points of view: First, the possible prophylactic effect of administering knowni quantities of the substance to previously rheumatic subjects, and(l second, the possible curative effect of large doses given to patients with the active disease.