Eimeria tenella infection perturbs the chicken gut microbiota from the onset of oocyst shedding

Tang, Xiaoli; Bi, Feifei; Hao, Zhenkai; Han, Zhenyan; Suo, Jingxia; Zhang, Sixin; Wang, Si; Duan, Chunhui; Yu, Zhengquan; Yu, Fang; Yu, Yonglan; Lv, Yanli; Suo, Xun; Liu, Xianyong

doi:10.1016/j.vetpar.2018.06.005

Cited by 54 publications

(40 citation statements)

References 33 publications

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“…The decrease in diversity and large alterations in taxonomic composition on dol 11 may support previous findings that protozoan infections can disrupt the enteric microbiota. As a consequence, the resulting dysbiosis may alter the clinical and pathological outcome of parasitic infections, as previously shown for coccidiosis in chickens (Macdonald et al, 2017;Huang et al, 2018a) and mice (Huang et al, 2018b) and cryptosporidiosis in mice and humans (Chappell et al, 2016;Mammeri et al, 2019).…”

Section: Discussionmentioning

confidence: 78%

“…Early life colonization of gut microbiota is vital to animal health, as it influences the microbial profile and intestinal health at later stages of life (Ke et al, 2019). Pathogenic protozoan parasites can interfere with the intestinal microbiota (Ras et al, 2015;Chabé et al, 2017;Huang et al, 2018a;Mammeri et al, 2019). In suckling piglets, C. suis commonly parasitizes the epithelial cells of the small intestine and is closely related to Cystoisospora belli of humans (Almeria et al, 2020) and is considered a major diarrheal pathogen (Joachim and Shrestha, 2020).…”

Section: Discussionmentioning

confidence: 99%

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Shifts in the Fecal Microbial Community of Cystoisospora suis Infected Piglets in Response to Toltrazuril

et al. 2020

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Shifts in the Fecal Microbial Community of Cystoisospora suis Infected Piglets in Response to Toltrazuril

et al. 2020

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“…In groups M and G, from 105 hpi to 144 hpi, beneficial bacteria decreased, and conditional pathogenic bacteria increased. Huang et al [22] found similar performance both in the infected AA broiler and White Leghorn chickens at 120 hpi, where the relative abundance of Lactobacillus and Faecalibacterium decreased, and the relative abundance of the pathobionts Clostridium, Lysinibacillus and Escherichia increased. In our study the microbiota was greatly impacted, but no significant variation in alpha diversity was observed between the control group and the infected groups.…”

Section: Discussionmentioning

confidence: 89%

“…MacDonald et al [21] reported that E. tenella infection induced significant changes in the abundance of some microbial taxa with notable differences detected between lesion score categories, and severe pathology was associated with an increase of Enterobaceteriaceae and a decrease of Bacillales and Lactobacillales. Huang et al [22] also found that perturbation of the microbiota was observed both in Arbor Acres (AA) broilers and White Leghorn chickens by 16S rRNA sequencing during the oocyst shedding period in response to E. tenella infection, Clostridium and Escherichia increased, Lactobacillus and Faecalibacterium decreased. In the present study, our aim was to determine the changes in bacterial populations belonging to the cecal lumen in AA broilers using 16S rRNA gene sequencing, to explore the dynamics of the microbiota associated with the different phases of E. tenella infection within an intact life-cycle.…”

Section: Introductionmentioning

confidence: 98%

Dissection of the cecal microbial community in chickens after Eimeria tenella infection

Chen

Zhao

et al. 2020

Parasites Vectors

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Background: Eimeria spp. are responsible for chicken coccidiosis which is the most important enteric protozoan disease resulting in tremendous economic losses in the poultry industry. Understanding the interaction between the avian cecal microbiota and coccidia is of interest in the development of alternative treatments that do not rely on chemotherapeutics and do not lead to drug resistance. Methods: We utilized 16S rRNA gene sequencing to detect the dynamics of the cecal microbial community in AA broilers challenged with Eimeria tenella. Histopathological analysis of the cecum was also conducted. Results: We found that microbial shifts occur during the infection. Lactobacillus, Faecalibacterium, Ruminococcaceae UCG-013, Romboutsia and Shuttleworthia decreased in abundance. However, the opportunistic pathogens Enterococcus and Streptococcus increased in abundance over time in response to the infection. Conclusions: Eimeria tenella disrupts the integrity of the cecal microbiota and could promote the establishment and growth of potentially pathogenic bacteria. Defining bacterial populations affected by coccidial infection might help identify bacterial markers for intestinal disease as well as populations or species that could be beneficial in maintaining and restoring gut homeostasis during and after infection with E. tenella.

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“…The severity or level of pathogenicity observed in an infection depends on the species of Eimeria causing the infection (Brown-Jordan et al ., 2018). E. mitis and E. praecox (low pathogenicity) and E. acervulina and E. maxima (moderate pathogenicity) induce a mild coccidial infection, whereas E. brunetti, E. necatrix and E. tenella (high pathogenicity) bring about internal haemorrhaging, predisposing the birds to necrotic enteritis and, in rare instances, lead to death (Barbour et al ., 2015; Huang et al ., 2018; Macdonald et al ., 2019).…”

Section: Impact and Diagnosis Of Poultry Coccidiosismentioning

confidence: 99%

Emerging threat ofEimeriaoperational taxonomic units (OTUs) on poultry production

Venkatas

Adeleke

2019

Parasitology

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Coccidiosis is an antagonistic poultry disease which negatively impacts animal welfare and productivity. The disease is caused by an obligate, intracellular protozoon known as Eimeria. Several Eimeria species known to infect chickens have been well documented. However, recent studies have elucidated the emergence of three novel genetic variants or operational taxonomic units (OTUs). The discovery of OTUx, OTUy and OTUz complicates the identification and diagnosis of coccidiosis. OTUs are clusters of unknown or uncultivated organisms that are grouped according to a similarity in DNA sequence to a set of specific gene markers. OTUs have been reported in the Earth's Southern Hemisphere, including Australia, Venezuela, India, Zambia, Uganda, Tanzania, China and Ghana. Elucidating their impact on the poultry industry is fundamental in preventing anticoccidial resistance and to access the potential of OTUs as vaccine candidates to provide cross-protection against similar Eimeria species. The identification of OTUs further decreases the risk of false negative coccidial diagnosis. Therefore, this article reviews the importance and risk imposed by OTUs, coupled with their prevalence and geographical distribution in chickens globally.

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Eimeria tenella infection perturbs the chicken gut microbiota from the onset of oocyst shedding

Cited by 54 publications

References 33 publications

Shifts in the Fecal Microbial Community of Cystoisospora suis Infected Piglets in Response to Toltrazuril

Shifts in the Fecal Microbial Community of Cystoisospora suis Infected Piglets in Response to Toltrazuril

Dissection of the cecal microbial community in chickens after Eimeria tenella infection

Emerging threat ofEimeriaoperational taxonomic units (OTUs) on poultry production

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