Eimeria nieschulzi and Trichinella spiralis: Analysis of concurrent infection in the rat

Stewart, G. W.; Reddington, John J.; Hamilton, Ann Marie

doi:10.1016/0014-4894(80)90013-2

Cited by 12 publications

(1 citation statement)

References 15 publications

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“…unaltered patency, but enhancement of egg production (Mayberry, Bristol & Villalobos, 1985). Also Stewart, Reddington & Hamilton (1980) recovered fewer adult T. spiralis worms when rats were concurrently infected with E. nieschulzi. This may have been due to a failure of the larvae to establish in the small intestine: T. spiralis was given 9 days after E. nieschulzi, when the small intestine would have been severely affected by the coccidial infection (Rose & Hesketh, 1982) and the differences in worm recovery were apparent when the intestines were first sampled, on day 5 p.i.…”

Section: Discussionmentioning

confidence: 96%

Interactions between infections with Eimeria spp. and Trichinella spiralis in inbred mice

1994

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Parasitological and immunological interactions between Eimeria vermiformis or E. pragensis and Trichinella spiralis were investigated during concurrent infections in NIH, BALB/c and B10.G inbred mice. The establishment of T. spiralis was unaffected by the presence of either coccidium, but expulsion of adult worms was delayed significantly in mice infected with E. vermiformis; E. pragensis did not have this effect. Replication of E. vermiformis was enhanced in concurrent infections with T. spiralis, but that of E. pragensis was reduced. Specific immune responses to each parasite were unaffected in mice infected with T. spiralis and E. pragensis, but levels of some responses were reduced when T. spiralis and E. vermiformis were combined. Thus both in vitro antigen-induced proliferation of mesenteric lymph node cells (MLNC) and intestinal mastocytosis were lower than in singly infected mice. Mitogen (Con A) responsiveness of MLNC was not affected in mice infected with T. spiralis and E. vermiformis, and cells from these mice were capable of transferring protective immunity to the nematode in naive recipients. Injection of monoclonal antibody to interferon gamma, a major component of the cytokine response to E. vermiformis, did not prevent delay of worm expulsion in concurrent infections. The results are discussed in terms of possible interactions between the T helper cell subsets or the inflammatory components of the responses induced by each parasite.

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Section: Discussionmentioning

confidence: 96%

Interactions between infections with Eimeria spp. and Trichinella spiralis in inbred mice

1994

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Enteric Protozoans:Cyclospora, Eimeria, Isospora, andCryptosporidiumspp.

Duszynski¹,

Upton²

2001

Parasitic Diseases of Wild Mammals

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Heterologous antagonistic and synergistic interactions between helminths and between helminths and protozoans in concurrent experimental infection of mammalian hosts

et al. 1987

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Experimental concurrent infection with two or more parasite species in mammalian host models may result in heterologous antagonistic and synergistic interactions ranging in magnitude from reduced/enhanced growth and fecundity to blockage/enhancement of establishment/expulsion. With some exceptions only, there is a reasonable correlation between the levels of interaction monitored by parasitological and by clinico-pathological parameters. Heterologous antagonistic interactions mediated by functional and specific immunological cross-reactivity occur between closely related parasite species exhibiting a marked immunobiological similarity. In contrast, antagonistic interactions between antigenetically more remote species of helminths, protozoan-induced resistance to helminth infection and helminth-induced suppression of concurrent protozoan infection generally appear mediated by immunologically non-specific factors like macrophage activation and inflammatory reactions. Synergistic heterologous interactions between helminths, helminth-induced enhancement of concurrent protozoan infection and interference with the development and maintenance of resistance to helminth infection in response to concurrent protozoan infection are generally thought to be mediated by non-specific parasite-induced immunosuppression. Concurrent experimental infection is very complex. There are problems and limitations in extrapolating from experimental studies on concurrent infection in laboratory animals to natural polyparasitism. This fact, coupled with the complex influence of ecological factors on the pattern and frequency of concurrent natural infection means that major consequences of natural concurrent parasite infection have not been definitively demonstrated. Appropriately planned and controlled field studies and further laboratory experiments on primate and domestic animal models are imperative for elucidation of the importance of heterologous interactions in concurrent parasite infection for the disease pattern in man and domestic stock. Experimental studies hitherto conducted on concurrent parasite infection pointing to natural heterologous interactions may be a valuable starting point for further studies.

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Eimeria nieschulzi and Trichinella spiralis: Analysis of concurrent infection in the rat

Cited by 12 publications

References 15 publications

Interactions between infections with Eimeria spp. and Trichinella spiralis in inbred mice

Interactions between infections with Eimeria spp. and Trichinella spiralis in inbred mice

Enteric Protozoans:Cyclospora, Eimeria, Isospora, andCryptosporidiumspp.

Heterologous antagonistic and synergistic interactions between helminths and between helminths and protozoans in concurrent experimental infection of mammalian hosts

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