Eight Further Cases of Radiation-induced Cancer

Radiation-induced cancer after radiotherapy for non-Hodgkin's lymphoma of the head and neck: a retrospective study

“…McHugh et al compared the characteristics of radiation-induced craniofacial osteosarcoma with those of the corresponding primary tumors, and proposed that the poorer prognosis of radiation-induced osteosarcoma was related to the higher expression of adverse prognostic markers, such as p53, TP53 mutations, ezrin expression, and the higher proliferative activity [ 34 ]. In contrast, there are some reports of laryngeal and pharyngeal cancer after radiation for thyrotoxicosis and tuberculous lymphadenitis being successfully treated by radiation from a linear accelerator [ 35 , 36 ]. The choice of the therapeutic modality for radiation-induced cancer is affected not only by the nature of the tumor, but also by several patient factors, mainly the extent of the existing tissue damage.…”

Twelve cases of glottic carcinoma in situ treated by radiotheraphy: an observation on clinical course versus response

“…These are highly likely to be radiogenic in origin, but as 17 per cent of laryngeal carcinomas are associated with metachronous or synchronous neoplasia (Chacko et al, 1983) it would be difficult to ascribe perilaryngeal neoplasia in an irradiated larynx to the radiotherapy. Two other arguments against this as a criticism are that skin lesions (the most common radiogenic neoplasia) are rarely seen and in long-term follow-up of early radiotherapy (external beam) of thyrotoxicosis, de novo neoplasia manifested between 20 and 44 years after treatment (Garrett, 1959). This is beyond the life expectancy of most people with glottic carcinoma.…”

Radiation-induced esophageal carcinoma

“…The most common location is the skin but such tumors have also been documented to occur in the thyroid, bone, breast, larynx, lung, bladder, and salivary glands [5]. Radiation-induced cancers o f the gastrointestinal tract are relatively rare and primarily originate in the pharynx, colon and rectum [6][7][8].…”