Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes

Mita, Tomoya; Watada, Hirotaka; Ogihara, Takeshi; Nomiyama, Takashi; Ogawa, Osamu; Kinoshita, Junichiro; Shimizu, Tomoaki; Hirose, Takahisa; Tanaka, Yasushi; Kawamori, Ryuzo

doi:10.1016/j.atherosclerosis.2006.03.005

Cited by 134 publications

(105 citation statements)

References 32 publications

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“…They were all blinded to the clinical features of the subjects. We have previously demonstrated good intraday and interday reproducibility of our examination [16].…”

Section: Assessment Of Common Carotid Artery Imtmentioning

confidence: 60%

Association of C-reactive Protein with Early-stage Carotid Atherosclerosis in Japanese Patients with Early-state Type 2 Diabetes Mellitus

et al. 2006

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Abstract. The aim of this study was to assess the association between high sensitivity-C-reactive protein (hs-CRP), a sensitive marker of inflammation, and early-stage carotid atherosclerosis, in patients with early-state type 2 diabetes mellitus. The study subjects were 75 patients with type 2 diabetes mellitus without obvious diabetic vascular complications, who were not on any medication, and whose HbA 1c level was less than 6.5%. We evaluated the mean intima-media thickness (IMT) of the common carotid artery (CCA) by ultrasound B-mode imaging. Then, we investigated various factors associated with CCA-IMT including hs-CRP. Serum hs-CRP levels correlated well with factors strongly associated with insulin resistance such as homeostasis model assessment of insulin resistance (HOMA-IR), fasting insulin level, and body mass index. Serum hs-CRP also correlated with mean CCA-IMT and serum levels of soluble intercellular adhesion molecule-1. Multivariate regression analysis using mean CCA-IMT as the dependent variable identified only age, hs-CRP, and diastolic blood pressure as independent determinants of mean CCA-IMT. While hs-CRP associates with insulin resistance and subclinical atherosclerosis in ealy-state type 2 diabetes, our data suggest that hs-CRP is a useful marker of subclinical atherosclerosis in early-state type 2 diabetes mellitus independent of factors that directly reflect insulin resistance.

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“…They were all blinded to the clinical features of the subjects. We have previously demonstrated good intraday and interday reproducibility of our examination [16].…”

Section: Assessment Of Common Carotid Artery Imtmentioning

confidence: 60%

Association of C-reactive Protein with Early-stage Carotid Atherosclerosis in Japanese Patients with Early-state Type 2 Diabetes Mellitus

et al. 2006

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“…In this study, we also confirmed the significant reduction of PWV by EPA treatment, which is consistent with an earlier report on the effect of EPA on carotid intima-media thickness and PWV in diabetic patients. 12 In the multicentered Japan Obesity and Metabolic Syndrome Study, we recently reported that CAVI is less influenced by BP and more closely correlated than PWV with the severity of metabolic syndrome and hypoadiponectinemia in obese subjects. We suggested that CAVI is useful to evaluate atherogenic risks in metabolic syndrome.…”

Section: Discussionmentioning

confidence: 96%

“…12 However, as PWV tends to be affected by the change in BP, 13 it is not currently known whether EPA can directly improve arterial stiffness. Recently, the cardio-ankle vascular index (CAVI), an index for estimating arterial stiffness, has been developed.…”

Section: Introductionmentioning

confidence: 99%

Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome

et al. 2009

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A recent clinical trial revealed that highly purified eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid, reduces the incidence of cardiovascular diseases. However, the detailed mechanism underlying the anti-atherogenic effect of EPA is still poorly understood. In this study, we examined the effect of EPA on cardio-ankle vascular index (CAVI), a new index of arterial stiffness that is less influenced by blood pressure (BP), as well as on serum amyloid A-low-density lipoprotein (SAA-LDL), an oxidized LDL (oxLDL), in the metabolic syndrome. Ninety-two obese Japanese subjects with metabolic syndromes were randomly divided into two groups (n¼46): the EPA-treated group (1.8 g administered daily for 3 months) and the control group. Measurements were taken to assess the changes in glucose-lipid metabolism, SAA-LDL, C-reactive protein (CRP), leptin, adiponectin and pulse wave velocity (PWV), and CAVI. EPA treatment significantly reduced the levels of immunoreactive insulin, triglycerides, SAA-LDL, CRP, PWV and CAVI and increased the levels of adiponectin relative to the control group for 3 months (Po0.05). Stepwise multivariate linear regression analysis revealed that the only significant determinant for a decrease in CAVI by EPA is a reduction in SAA-LDL (Po0.05). Moreover, the EPA-induced reduction of SAA-LDL was only significantly correlated with a decrease in total cholesterol and an increase in adiponectin (Po0.05). This study is the first demonstration that EPA improves arterial stiffness and is less influenced by BP, possibly through the suppression of SAA-LDL, thereby leading to a reduction in the frequency of cardiovascular disease development in metabolic syndrome.

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“…38 Several interventional studies have assessed the impact of omega-3 supplementation on vascular stiffness. Some groups reported a beneficial effect of omega-3 supplementation on vascular stiffness, [39][40][41][42] whereas others observed no effect. 43,44 Generally, these investigations were of very limited size, and large studies are lacking.…”

Section: Omega-3 Fatty Acids and Vascular Stiffnessmentioning

confidence: 99%

The relation of red blood cell fatty acids with vascular stiffness, cardiac structure and left ventricular function: The Framingham Heart Study

et al. 2014

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Polyunsaturated fatty acids have been associated with beneficial influences on cardiovascular health. However, the underlying mechanisms are not clear, and data on the relations of polyunsaturated fatty acids to subclinical disease measures such as vascular stiffness and cardiac function are sparse and inconclusive. In a large community-based cohort, we examined the relations of omega-3 and other fatty acids to a comprehensive panel of vascular function measures (assessing microvascular function and large artery stiffness), cardiac structure and left ventricular function. Red blood cell (RBC) membrane fatty acid composition, a measure of long-term fatty acid intake, was assessed in participants of the Framingham Offspring Study and Omni cohorts and related to tonometry-derived measures of vascular stiffness and to a panel of echocardiographic traits using partial correlations. Up to n=3055 individuals (56% women, mean age 66 years) were available for analyses. In age-and sex-adjusted models, higher RBC omega-3 content was moderately associated (p≤0.002) with several measures of vascular stiffness and function in a protective direction. However, after multivariable adjustment, only an association of higher RBC omega-3 content with lower carotid-femoral pulse wave velocity (a measure of aortic stiffness) remained significant (r = -0.06, p=0.002). In secondary analyses, higher linoleic acid, the major nutritional omega-6 fatty acid, was associated with smaller left atrial size, even after multivariable adjustment (r = -0.064, p<0.001). In conclusion, in our cross-sectional community-based study, we found several associations consistent with the notion of protective effects of omega-3 and linoleic acid. The clinical significance of these modest associations remains to be elucidated.

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Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes

Cited by 134 publications

References 32 publications

Association of C-reactive Protein with Early-stage Carotid Atherosclerosis in Japanese Patients with Early-state Type 2 Diabetes Mellitus

Association of C-reactive Protein with Early-stage Carotid Atherosclerosis in Japanese Patients with Early-state Type 2 Diabetes Mellitus

Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome

The relation of red blood cell fatty acids with vascular stiffness, cardiac structure and left ventricular function: The Framingham Heart Study

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