Association of C-reactive Protein with Early-stage Carotid Atherosclerosis in Japanese Patients with Early-state Type 2 Diabetes Mellitus

Mita, Tomoya; Watada, Hirotaka; Uchino, Hiroshi; Shimizu, Tomoaki; Hirose, Takahisa; Tanaka, Yasushi; Kawamori, Ryuzo

doi:10.1507/endocrj.k06-042

Cited by 23 publications

(18 citation statements)

References 24 publications

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“…In agreement with previous studies [19,[22][23][24], we demonstrated that hypertension (high diastolic blood pressure) and dyslipidemia (low HDL-cholesterol level), components of metabolic syndrome, were associated with carotid IMT independently of known cardiovascular risk factors. Although, smoking is well known to be an independent risk factor of CVD, we failed to demonstrate the significant association between smoking status and carotid IMT in our study.…”

Section: Discussionsupporting

confidence: 93%

Is Central Obesity a Good Predictor of Carotid Atherosclerosis in Japanese Type 2 Diabetes with Metabolic Syndrome?

et al. 2007

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Abstract. Metabolic syndrome has been revealed to be a major risk factor for cardiovascular disease (CVD) and early mortality in non-diabetic and diabetic patients. In 2005, the International Diabetes Federation (IDF) and the Examination Committee of Criteria for Diagnosis of Metabolic Syndrome in Japan published new definitions of metabolic syndrome in which central obesity was an indispensable factor. However, the significance of this new definition to CVD in type 2 diabetes has not yet been clarified. A cross-sectional study was conducted with 294 Japanese type 2 diabetic patients without known cardiovascular disease to evaluate the association between metabolic syndrome defined by this new definition and carotid atherosclerosis, and the significance of central obesity for the prediction of the development of carotid atherosclerosis. In a multivariate regression analysis, metabolic syndrome but not central obesity was significantly associated with carotid intima-media thickness (IMT) independent of known cardiovascular risk factors (p<0.05). In addition, whereas carotid IMT was significantly increased according to the increase in the number of components of metabolic syndrome, it was not significantly different between the groups with the same number of components of metabolic syndrome with or without central obesity. These findings suggest that the prediction of the development of carotid atherosclerosis in Japanese type 2 diabetic patients could be improved by the assessment of aggregation of components of metabolic syndrome rather than with or without metabolic syndrome by this new definition.

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Section: Discussionsupporting

confidence: 93%

Is Central Obesity a Good Predictor of Carotid Atherosclerosis in Japanese Type 2 Diabetes with Metabolic Syndrome?

et al. 2007

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“…It has been thought that serum hs‐CRP level leads to the development of atherosclerosis5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16. Although various new pharmacological approaches have been introduced to reduce hs‐CRP levels17, 18, 19, 20, 21, 22, 23, 24, 25, 26, there are still many cardiovascular diseases all over the world.…”

Section: Discussionmentioning

confidence: 99%

“…An increase of serum high‐sensitivity C‐reactive protein (hs‐CRP) level likely leads to the development of atherosclerosis. Indeed, it has been reported that hs‐CRP level is associated with carotid atherosclerosis in patients with type 2 diabetes mellitus5, 6, 7, 8, suggesting that hs‐CRP is a useful marker to predict an accelerated atherosclerotic process. It has also been shown that elevated hs‐CRP levels are associated with increased cardiovascular risk9, 10, 11, 12.…”

Section: Introductionmentioning

confidence: 99%

Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients

Shimoda

Kaneto

Yoshioka

et al. 2015

J of Diabetes Invest

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Aims/IntroductionIncreased levels of high‐sensitivity C‐reactive protein (hs‐CRP) likely leads to the development of atherosclerosis. Therefore, it is very important to know which factors largely influence hs‐CRP levels. In the present study, we examined the influence of various atherosclerosis‐related factors on hs‐CRP levels in patients with type 2 diabetes.Materials and MethodsA total of 275 patients (176 men, 99 women) were enrolled in this study. We tested the relationship between the number of risk factors reaching a desired value and hs‐CRP levels. The Mann–Whitney U‐test was used to compare two groups. The Kruskal–Wallis test was used to carry out overall group comparisons, and the Steel–Dwass test was used to carry out between‐group comparisons. Spearman's rank correlation was carried out to study the correlation between hs‐CRP levels and clinical parameters. Multivariate regression method was used to analyze the factors independently contributing to hs‐CRP levels.ResultsHs‐CRP levels were lower in patients with a larger number of risk factors reaching a desired value. In particular, triglyceride and body mass index (BMI) were independent risk factors determining hs‐CRP levels in a multivariate regression analysis. Furthermore, we compared the influence of various factors on hs‐CRP levels in both obese (BMI ≥25 kg/m2) and non‐obese patients with type 2 diabetes (BMI <25 kg/m2). In obese groups, BMI and urinary albumin were independent risk factors determining hs‐CRP levels, whereas triglyceride and statin were independent risk factors in non‐obese patients.ConclusionsThere is some difference in the factors responsible for hs‐CRP levels in obese and non‐obese patients with type 2 diabetes.

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“…This proposed relationship between HbA 1c and CA 19-9 is supported by our study. Given that the inflammatory processes are important in etiology (27) as well as in complications of diabetes (28), these findings could be mediated through inflammation.…”

Section: Discussionmentioning

confidence: 99%

Increased CA 19-9 level in patients without malignant disease

Kim

Lee

Kim

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: The measurement of carbohydrate antigen 19-9 (CA 19-9) is recommended for the diagnosis and follow-up of pancreatic cancer. However, increased CA 19-9 has also been reported in patients with various benign diseases of the lung. We aimed to elucidate the pulmonary radiographic abnormalities and laboratory results associated with increased concentrations of CA 19-9. Methods: This study was performed using a case-controlled design. Cases included all participants in a cancer screening program who had an increased CA 19-9 concentration ()37 U/mL), but without a diagnosis of malignancy. Age-and sex-matched participants with normal CA 19-9 levels were enrolled as controls. Laboratory results and radiographic features were compared. Results: In total, 119 participants with increased CA 19-9 concentrations and 476 controls were included. A higher erythrocyte sedimentation rate (ESR) wadjusted odd ratio (aOR), 1.03; 95% confidence interval (CI), 1.01-1.05x, higher hemoglobin A 1c (HbA 1c

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Association of C-reactive Protein with Early-stage Carotid Atherosclerosis in Japanese Patients with Early-state Type 2 Diabetes Mellitus

Cited by 23 publications

References 24 publications

Is Central Obesity a Good Predictor of Carotid Atherosclerosis in Japanese Type 2 Diabetes with Metabolic Syndrome?

Is Central Obesity a Good Predictor of Carotid Atherosclerosis in Japanese Type 2 Diabetes with Metabolic Syndrome?

Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients

Increased CA 19-9 level in patients without malignant disease

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