Eicosanoids and fat emulsions in acute respiratory distress syndrome patients

Planas, M.; Masclans, Joan Ramón; Iglesia, Raquel; Porta, I.; Valls, Montserrat; Bermejo, B.

doi:10.1016/s0899-9007(96)00402-9

Cited by 19 publications

(7 citation statements)

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“…We previously observed a significant decrease in systemic-pulmonary arterial 6-keto-prostaglandin c~ (a stable inactive metabolite of the vasodilator prostacyclin) difference in ARDS patients treated with LCT emulsion, a reduction that was possibly due to a tendency of this marker to increase at the pulmonary arterial levels and due also to a trend to decrease at the systemic arterial level [20].…”

Section: Discussionmentioning

confidence: 96%

Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome

et al. 1998

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Section: Discussionmentioning

confidence: 96%

Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome

et al. 1998

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“…Of course, MCT intake may induce ketosis, with the limitations that this presents in patients with diabetes mellitus or in similar situations [37]. Comparing patients with ARDS treated with LCT vs. LCT/MCT emulsions, our group reported neutral results in eicosanoid synthesis [38]. A lower amount of PUFA n-6 is provided in LCT/MCT emulsions, but the n-6/n-3 ratio is not changed, with the result that non-recommendable values may theoretically persist.…”

Section: Discussionmentioning

confidence: 99%

Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS): A prospective, randomized, double-blind, parallel group study

et al. 2011

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BackgroundThe use of lipid emulsions has been associated with changes in lung function and gas exchange which may be mediated by biologically active metabolites derived from arachidonic acid. The type and quantity of the lipid emulsions used could modulate this response, which is mediated by the eicosanoids. This study investigates the use of omega-3 fatty acid-enriched lipid emulsions in ARDS patients and their effects on eicosanoid values.MethodsProspective, randomized, double-blind, parallel group study carried out at the Intensive Medicine Department of Vall d'Hebron University Hospital (Barcelona-Spain). We studied 16 consecutive patients with ARDS and intolerance to enteral nutrition (14 men; age: 58 ± 13 years; APACHE II score 17.8 ± 2.3; Lung Injury Score: 3.1 ± 0.5; baseline PaO2/FiO2 ratio: 149 ± 40). Patients were randomized into two groups: Group A (n = 8) received the study emulsion Lipoplus® 20%, B. Braun Medical (50% MCT, 40% LCT, 10% fish oil (FO)); Group B (n = 8) received the control emulsion Intralipid® Fresenius Kabi (100% LCT). Lipid emulsions were administered for 12 h at a dose of 0.12 g/kg/h. We measured LTB4, TXB2, and 6-keto prostaglandin F1α values at baseline [immediately before the administration of the lipid emulsions (T-0)], at the end of the administration (T-12) and 24 hours after the beginning of the infusion (T 24) in arterial and mixed venous blood samples.ResultsIn group A (FO) LTB4, TXB2, 6-keto prostaglandin F1α levels fell during omega-3 administration (T12). After discontinuation (T24), levels of inflammatory markers (both systemic and pulmonary) behaved erratically. In group B (LCT) all systemic and pulmonary mediators increased during lipid administration and returned to baseline levels after discontinuation, but the differences did not reach statistical significance. There was a clear interaction between the treatment in group A (fish oil) and changes in LTB4 over time.ConclusionsInfusion of lipids enriched with omega-3 fatty acids produces significant short- term changes in eicosanoid values, which may be accompanied by an immunomodulatory effect.Trial registrationISRCTN63673813.

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“…Dans une étude ouverte en nutrition parentérale au long cours, le Médialipide ® aurait permis la normalisation des gamma GT à six mois [27]. En ce qui concerne les effets pulmonaires, les études sont là aussi contradictoires, mais difficilement comparables car leur méthodologie était différente [30][31][32][33][34][35][36][37]. Chez les patients ventilés, sans ARDS, il ne semble pas exister d'effet bénéfique à utiliser le Médialipide ® [30,31,37].…”

Section: Les éMulsions Contenant Des Triglycérides à Chaîne Moyenne Eunclassified

Émulsions lipidiques : indication des différentes émulsions lipidiques

Chambrier

Lauverjat

Boulétreau

2006

Nutrition Clinique et Métabolisme

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Eicosanoids and fat emulsions in acute respiratory distress syndrome patients

Cited by 19 publications

References 23 publications

Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome

Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome

Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS): A prospective, randomized, double-blind, parallel group study

Émulsions lipidiques : indication des différentes émulsions lipidiques

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