Ehretianone, a Novel Quinonoid Xanthene from <i>Ehretia buxifolia</i> with Antisnake Venom Activity

Selvanayagam, Zachariah; Gnanavendhan, S. G.; Balakrishna, K.; Rao, R. Bhima; Sivaraman, J.; Subramanian, Karina; Puri, Raman

doi:10.1021/np960355p

Cited by 48 publications

(37 citation statements)

References 5 publications

(8 reference statements)

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“…To our knowledge, paranolin, isolated from Paraphaeosphaeria nolinae (IFB-E011) (Pleosporales), an endophyte of wormwood (Artemisia annua; Ge et al, 2006) is the only previous report of a fungal derived xanthene natural product. Various xanthenes exhibit anticancer (Chatterjee et al, 1996), antivenom (Selvanayagam et al, 1996), cytotoxic (Huang et al, 2010) and antifungal (Krasnoff et al, 1999) activity. Their pharmacological properties and use as industrial dyes have made numerous xanthenes the subject of chemical syntheses (Giri et al, 2010;Wu et al, 2005).…”

Section: Biological Activitymentioning

confidence: 99%

Antimicrobial dihydrobenzofurans and xanthenes from a foliar endophyte of Pinus strobus

et al. 2015

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Section: Biological Activitymentioning

confidence: 99%

Antimicrobial dihydrobenzofurans and xanthenes from a foliar endophyte of Pinus strobus

et al. 2015

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“…For their pharmaceutical properties, see: Dimmock et al (1988); Lambert et al (1997); Poupelin et al (1978); Hideo (1981); Selvanayagam et al (1996). For bond-length data, see: Allen et al (1987) Mehdi et al (2011);Sughanya & Sureshbabu (2012).…”

Section: Related Literaturementioning

confidence: 99%

“…Xanthene derivatives are used as dyes (Hilderbrand & Weissleder, 2007), possess biological properties like antibacterial, antiviral and anti-inflammatory (Dimmock et al, 1988) activities and are used in medicine. Ehretianone, a quinonoid xanthene was reported to possess antisnake venom activity (Selvanayagam et al, 1996;Lambert et al, 1997;Poupelin et al, 1978;Hideo, 1981).…”

Section: S1 Commentmentioning

confidence: 99%

9-(2,4-Dinitrophenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

Sureshbabu

Sughanya

2013

Acta Cryst E

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Key indicators: single-crystal X-ray study; T = 296 K; mean (C-C) = 0.002 Å; R factor = 0.052; wR factor = 0.159; data-to-parameter ratio = 25.4.In the title compound, C 23 H 24 N 2 O 7 , the central 4H-pyran ring adopts a flattened boat conformation, whereas both cyclohexenone rings adopt envelope conformations, the C atom bearing the dimethyl substituent being the flap atom in each case. The mean and maximum deviation of the pyran ring are 0.0379 (4) and 0.0605 (3) Å . The mean plane of the pyran ring and the dinitrobenzene ring make a dihedral angle of 85.88 (2) . Related literature

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“…Many active ingredients from snake venoms have been purified. Their molecular structures have been identified and characterized in the most advanced laboratories (Ferreira et al 1992;Selvanayagam et al 1996;Abubakar et al 2000;Batina et al 2000;Aguiyi et al 2001;Mahanta and Mukherjee, 2001). …”

Section: Introductionmentioning

confidence: 99%

Plant-antivenom: Database of anti-venom medicinal plants

Amui

Puga

Soares

et al. 2001

Electron. J. Biotechnol.

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Plant-antivenom is a computational Websystem about medicinal plants with anti-venom properties. The system consists of a database of these plants, including scientific publications on this subject and amino acid sequences of active principles from venomous animals. The system relates these data allowing their integration through different search applications. For the development of the system, the first surveys were conducted in scientific literature, allowing the creation of a publication database in a library for reading and user interaction. Then, classes of categories were created, allowing the use of tags and the organization of content. This database on medicinal plants has information such as family, species, isolated compounds, activity, inhibited animal venoms, among others. Provision is made for submission of new information by registered users, by the use of wiki tools. Content submitted is released in accordance to permission rules defined by the system. The database on biological venom protein amino acid sequences was structured from the essential information from National Center for Biotechnology Information (NCBI). Plant-antivenom's interface is simple, contributing to a fast and functional access to the system and the integration of different data registered on it. Plant-antivenom system is available on the Internet at

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Ehretianone, a Novel Quinonoid Xanthene from Ehretia buxifolia with Antisnake Venom Activity

Cited by 48 publications

References 5 publications

Antimicrobial dihydrobenzofurans and xanthenes from a foliar endophyte of Pinus strobus

Antimicrobial dihydrobenzofurans and xanthenes from a foliar endophyte of Pinus strobus

9-(2,4-Dinitrophenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

Plant-antivenom: Database of anti-venom medicinal plants

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