Egyptian recommendations for management of Helicobacter pylori infection: 2018 report

Alboraie, Mohamed; Elhossary, Walied; Aly, Osama Aboelfotoh; Abbas, Bahaa; Abdelsalam, Lobna; Ghaith, Doaa; Shady, Zakarya; Gaber, Yasmine; Adel, Eman; Peura, David A.; Armstrong, David; Esmat, Gamal

doi:10.1016/j.ajg.2019.09.001

Cited by 21 publications

(35 citation statements)

References 45 publications

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“…In Egypt, another North African country, a consensus reached by experts in 2017 on the diagnosis of HPI in the country recommended the use of SAT, which is widely available in Egypt; histological detection of H. pylori; and assessment of atrophy; RUT; and UBT. Although prior to this, diagnosis has been mainly based on histology and SAT [64]. In Libya, most studies relied on serological methods for diagnosing HPI using ELISA that assayed for anti-H. pylori IgG [67][68][69].…”

Section: Non-invasive Invasivementioning

confidence: 99%

Helicobacter pylori Infection in Africa: Update of the Current Situation and Challenges

Smith¹,

Ajayi²,

Jolaiya³

et al. 2021

Dig Dis

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Background: The burden of Helicobacter pylori infection (HPI) in Africa remains high with varying levels of prevalence among children and adults reported in different regions of the continent. Persistent and uneradicated HPI could result in gastric cancer, although less severe pathological outcomes have been reported among Africans – the so-called “African enigma.” Summary: Analysis of endoscopic findings of the upper gastrointestinal tract demonstrates similarities with that of patients from the West. Thus, it could be asserted that the true picture of HPI in Africa is yet to be unveiled due to several challenges including inadequate health-care system, lack of treatment guidelines and standardized protocol for diagnosis, and lack of data. This review explores the prevalence, diagnosis, treatment, and health-care system in Africa as it relates to HPI, thus providing an update and highlighting the need for an African HPI guideline. Key Messages: There is high prevalence of Helicobacter pylori infection (HPI) in Africa with an increasing burden of antibiotic resistance. Various methods including invasive and noninvasive methods are deployed in the diagnosis of HPI in Africa. There is a need for consensus on diagnosis and treatment of HPI in Africa.

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Section: Non-invasive Invasivementioning

confidence: 99%

Helicobacter pylori Infection in Africa: Update of the Current Situation and Challenges

Smith¹,

Ajayi²,

Jolaiya³

et al. 2021

Dig Dis

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“…Endoscopic guided antibiotic susceptibility testing may guide treatment after failure of second-line therapies. 7 The last consensus for H. pylori management in Egypt recommended the same first-and second-line therapies as the international guidelines 8 ; however, many studies recommend the identification of H. pylori antibiotic resistance. We aimed to evaluate the susceptibility and resistance of H. pylori to common antibiotics used in different treatment regimens.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Antibiotic Resistance in Egypt: A Single-Center Study

Metwally¹,

Ragab²,

Hamid³

et al. 2022

IDR

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Helicobacter pylori (H. pylori) is the most common human bacterial infection worldwide, infecting approximately half of the world's population. Although antibiotic use is indicated for H. pylori eradication, the recommended type of antibiotic varies from country to country according to the H. pylori resistance pattern; developing countries, such as Egypt, may have different patterns than developed countries. We evaluated the antibiotic resistance of H. pylori in Egypt. Methods: This cross-sectional study included 134 adult patients with upper gastrointestinal (GI) complaints. Patients with a history of PPI during the last 2 weeks or antibiotics during the last 4 weeks before endoscopy were excluded. Upper GI endoscopies were performed and biopsies were collected for histopathology and H. pylori culture. Demographic, clinical, and endoscopic data were also collected. Antimicrobial susceptibility testing for H. pylori was performed for nine therapeutically relevant antibiotics using the Kirby-Bauer disc diffusion method. Results: The H. pylori antibiotic resistance rates were as follows: moxifloxacin, 10%; doxycycline, 15%; levofloxacin, 20%; clarithromycin, 40%; azithromycin, 40%; erythromycin, 65%; rifampicin, 90%; amoxicillin, 95%; and metronidazole, 100%. Dual resistance rates were 40% for amoxicillin/clarithromycin, 40% for metronidazole/clarithromycin, and 95% for amoxicillin/metronidazole. Conclusion:In Egyptian patients, H. pylori had >90% resistance to metronidazole and amoxicillin; modest resistance to erythromycin, azithromycin, and clarithromycin; and low resistance to moxifloxacin, and levofloxacin (≤20%). Dual resistance was high for amoxicillin/clarithromycin and amoxicillin/metronidazole, which prefers using quinolones rather than clarithromycin or metronidazole for first-line treatment of H. pylori in Egypt.

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“…1 H. pylori is prevalent throughout the world but is specially more endemic in developing countries. [2][3][4] This infection is also present more in elderly persons than adolescents. 5,6 H. pylori infection causes many gastric diseases, such as chronic gastritis, peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study

Abo-Amer

Ahmed

et al. 2020

DMSO

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Background: Non-alcoholic fatty liver disease (NAFLD) is a very common disease that affects 25-30% of the population in western countries. Many studies have observed the importance of H. pylori infection in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and liver fibrosis and cirrhosis. However, the evidence from different studies was controversial. The present study aimed to investigate the relationship between H. pylori infection and NAFLD in a developing country. Patients and Methods: This cross-sectional study included all the attending outpatient clinics at four Major University hospitals and two research and clinical institutes in a developing country in the period between June and October 2019. Patients were assessed for the diagnosis of H. pylori infection as detected by H. pylori antigen in stool; they were also assessed for the diagnosis of NAFLD by ultrasound, fibroscan, and CAP. Results: The study was conducted on 646 patients; H. pylori infection was found to be present in 538 patients (83.3%). NAFLD (diagnosed by both U/S and Fibroscan with CAP), ALT, AST, hepatomegaly, hypertension, fasting blood sugar were significantly higher in H. pylori +ve group than H. pylori −ve group. After performing Linear regression of independent risk factors of NAFLD to prove or to refute the role of Helicobacter; H. pylori positivity, total cholesterol, degree of fatty liver by ultrasound, fasting blood sugar and diastolic blood pressure were independent risk factors for NAFLD. Conclusion: Helicobacter pylori infection was independent risk factors for NAFLD and correlated with increased degree of steatosis.

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Egyptian recommendations for management of Helicobacter pylori infection: 2018 report

Cited by 21 publications

References 45 publications

<b><i>Helicobacter pylori</i></b> Infection in Africa: Update of the Current Situation and Challenges

<b><i>Helicobacter pylori</i></b> Infection in Africa: Update of the Current Situation and Challenges

Helicobacter pylori Antibiotic Resistance in Egypt: A Single-Center Study

<p>Relationship Between <em>Helicobacter pylori</em> Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study</p>

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