Ego-rotation and object-rotation in major depressive disorder

Chen, Jiu; Yang, Lai-qi; Ma, Wentao; Wu, Xingqu; Zhang, Yan; Wei, Dunhong; Liu, Guangxiong; Deng, Zihe; Hua, Zhen; Jia, Ting

doi:10.1016/j.psychres.2012.10.003

Cited by 23 publications

(11 citation statements)

References 55 publications

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“…Together, our findings regarding mental movement simulation indicate an alteration in action representation and planning in depressed patients. This extends the results of previous studies highlighting impairment of mental transformation abilities in major depressive disorder (Rogers et al, 2000 ; Chen et al, 2013 ). In fact, compared to controls, MDD patients exhibit longer reaction times during mental rotation tasks and experience progressively greater slowing as a function of the angle of rotation, as a reflect of specific deficits of visuospatial cognitive operation (Chen et al, 2013 ).…”

Section: Discussionsupporting

confidence: 90%

“…This extends the results of previous studies highlighting impairment of mental transformation abilities in major depressive disorder (Rogers et al, 2000 ; Chen et al, 2013 ). In fact, compared to controls, MDD patients exhibit longer reaction times during mental rotation tasks and experience progressively greater slowing as a function of the angle of rotation, as a reflect of specific deficits of visuospatial cognitive operation (Chen et al, 2013 ). Comparing internally and externally cued response selection and initiation, several authors demonstrated that depressed patients were particularly slowed when movements involved internal movement selection (Rogers et al, 1987 , 2000 ; Hoffstaedter et al, 2012 ).…”

Section: Discussionsupporting

confidence: 90%

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Motor Imagery in Unipolar Major Depression

Bennabi

Monnin

Haffen

et al. 2014

Front. Behav. Neurosci.

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Background: Motor imagery is a potential tool to investigate action representation, as it can provide insights into the processes of action planning and preparation. Recent studies suggest that depressed patients present specific impairment in mental rotation. The present study was designed to investigate the influence of unipolar depression on motor imagery ability.Methods: Fourteen right-handed patients meeting DSM-IV criteria for unipolar depression were compared to 14 matched healthy controls. Imagery ability was accessed by the timing correspondence between executed and imagined movements during a pointing task, involving strong spatiotemporal constraints (speed/accuracy trade-off paradigm).Results: Compared to controls, depressed patients showed marked motor slowing on both actual and imagined movements. Furthermore, we observed greater temporal discrepancies between actual and mental movements in depressed patients than in healthy controls. Lastly, depressed patients modulated, to some extent, mental movement durations according to the difficulty of the task, but this modulation was not as strong as that of healthy subjects.Conclusion: These results suggest that unipolar depression significantly affects the higher stages of action planning and point out a selective decline of motor prediction.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Motor Imagery in Unipolar Major Depression

Bennabi

Monnin

Haffen

et al. 2014

Front. Behav. Neurosci.

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“…Mental rotation, as a reflection of visuospatial cognitive operation, is another useful tool for assessing motor preparation. During ego-rotation and object-rotation tasks, involving the creation of a mental image of an object and its subsequent rotation, MDD patients exhibited specific deficits compared to controls [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Psychomotor Retardation in Depression: A Systematic Review of Diagnostic, Pathophysiologic, and Therapeutic Implications

Bennabi

Vandel

Papaxanthis

et al. 2013

BioMed Research International

173

128

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Psychomotor retardation is a central feature of depression which includes motor and cognitive impairments. Effective management may be useful to improve the classification of depressive subtypes and treatment selection, as well as prediction of outcome in patients with depression. The aim of this paper was to review the current status of knowledge regarding psychomotor retardation in depression, in order to clarify its role in the diagnostic management of mood disorders. Retardation modifies all the actions of the individual, including motility, mental activity, and speech. Objective assessments can highlight the diagnostic importance of psychomotor retardation, especially in melancholic and bipolar depression. Psychomotor retardation is also related to depression severity and therapeutic change and could be considered a good criterion for the prediction of therapeutic effect. The neurobiological process underlying the inhibition of activity includes functional deficits in the prefrontal cortex and abnormalities in dopamine neurotransmission. Future investigations of psychomotor retardation should help improve the understanding of the pathophysiological mechanisms underlying mood disorders and contribute to improving their therapeutic management.

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“…PMR (paralysis plumbea) is also a feature of atypical depression [60] . It is associated with neurocognitive impairment (e.g., reaction time, visual attention tasks, and drawing tests) [61][62][63] and linked to decreased dopaminergic function, especially in basal ganglia [64] . Neuroimaging studies displayed impairments in the brain structures involved in the planning and control of motor responses [65] , as well as alterations in the connectivity between the anterior cingulated cortex, the dorso-lateral prefrontal cortex, and the pre-supplementary motor areas [66] .…”

Section: Vital Retardationmentioning

confidence: 99%

Abnormal Time Experiences in Major Depression: An Empirical Qualitative Study

et al. 2016

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Background: Phenomenological psychopathology, through theoretical and idiographic studies, conceptualizes major depressive disorder (MDD) as a disorder of time experience. Investigations on abnormal time experience (ATE) in MDD adopting methodologies requested by the standards of empirical sciences are still lacking. Our study aimed to provide a qualitative analysis, on an empirical ground and on a large scale, of narratives of temporal experiences of persons affected by MDD. Methods: We interviewed 550 consecutive patients affected by affective and schizophrenic disorders. Clinical files were analysed by means of consensual qualitative research. Results: Out of 100 MDD patients, 96 reported at least 1 ATE. The principal categories of ATE are vital retardation - the experience of a stagnation of endogenous vital processes (37 patients), the experience of present and future dominated by the past (29 patients), and the experience of the slackening of the flow oftime (25 patients). A comparison with ATE in schizophrenia patients showed that in MDD, unlike in schizophrenia, there is no disarticulation of time experience (disorder of temporal synthesis) but rather a disorder of conation or inhibition of becoming. Limitations: The interview style was not meant to make a quantitative assessment (“false negatives” cannot be excluded). Conclusions: Our findings confirm the relevance of distinctive features of ATE in MDD, support the hypothesis of an intrinsic disordered temporal structure in depressive symptoms, and may have direct implications in clinical practice, especially in relation to differential diagnosis, setting the boundaries between “true” and milder forms of depression, and neurobiological research.

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Ego-rotation and object-rotation in major depressive disorder

Cited by 23 publications

References 55 publications

Motor Imagery in Unipolar Major Depression

Motor Imagery in Unipolar Major Depression

Psychomotor Retardation in Depression: A Systematic Review of Diagnostic, Pathophysiologic, and Therapeutic Implications

Abnormal Time Experiences in Major Depression: An Empirical Qualitative Study

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