EGFR-targeted pemetrexed therapy of malignant pleural mesothelioma

Yang, Liang; Fang, Hui; Jiang, Jingjing; Sha, Yongjie; Zhong, Zhiyuan; Meng, Fenghua

doi:10.1007/s13346-021-01094-2

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The cRGD peptide facilitated penetration of these polymersomes to a depth of 200 μm within microtumor stem cells . Dual roles of the GE11 peptide in targeting MSTO-211H lung tumors and markedly increased tumor penetration of epidermal growth factor receptor-chimaeric polymersomes-pemetrexed (EGFR-CPs-PEM) was also reported . In another study, selective cell targeting, penetrating, and retention properties were imparted to reduction sensitive polymersomes by the CPP33 peptide for protein delivery .…”

Section: Active Targetingmentioning

confidence: 90%

“…39,40 41 Dual roles of the GE11 peptide in targeting MSTO-211H lung tumors and markedly increased tumor penetration of epidermal growth factor receptor-chimaeric polymersomes-pemetrexed (EGFR-CPs-PEM) was also reported. 42 In another study, selective cell targeting, penetrating, and retention properties were imparted to reduction sensitive polymersomes by the CPP33 peptide for protein delivery. 43 Moreover, Oz et al 44 used a type of breast cancer homing peptide, Peptide (18), to target integrin receptors for in vitro Doxorubicin (DOX) delivery.…”

Section: Active Targetingmentioning

confidence: 99%

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Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

Kayani,

Raza,

et al. 2023

Biomacromolecules

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Polymersomes have been extensively investigated for drug delivery as nanocarriers for two decades due to a series of advantages including high stability under physiological conditions, simultaneous encapsulation of hydrophilic and hydrophobic drugs inside inner cavities and membranes, respectively, and facile adjustment of membrane and surface properties, as well as controlled drug release through incorporation of stimuliresponsive components. Despite these features, polymersome nanocarriers frequently suffer from nontargeting delivery and poor membrane permeability. In recent years, polymersomes have been functionalized for more efficient drug delivery. The surface shells were explored to be modified with diverse active targeting groups to improve disease-targeting delivery. The membrane permeability of the polymersomes was adjusted by incorporation of the stimuliresponsive components for smart controlled transportation of the encapsulated drugs. Therefore, being the polymersome-biointerface, tailorable properties can be introduced by its carefully modulated engineering. This review elaborates on the role of polymersome membranes as a platform to incorporate versatile features. First, we discuss how surface functionalization facilitates the directional journey to the targeting sites toward specific diseases, cells, or intracellular organelles via active targeting. Moreover, recent advances in the past decade related to membrane permeability to control drug release are also summarized. We finally discuss future development to promote polymersomes as in vivo drug delivery nanocarriers.

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Section: Active Targetingmentioning

confidence: 90%

Section: Active Targetingmentioning

confidence: 99%

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

Kayani,

Raza,

et al. 2023

Biomacromolecules

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In Situ Enzyme‐Induced Self‐Assembly of Antimicrobial‐Antioxidative Peptides to Promote Wound Healing

Teng

Yang

Zhang

et al. 2023

Adv Funct Materials

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Antimicrobial peptides (AMPs) with dual intrinsic antibacterial and antioxidative functions have emerged as promising choice to cure infected wound. However, the most widely applied approach to endow AMPs with antioxidative function is to combine with antioxidative moieties, which may affect the spatial structure and physiological stability of AMPs. Herein, a new type of AMPs with inherent desired stability, antibacterial activity, and reactive oxygen species (ROS) scavenging is developed to effectively heal the infected wound. This formulation is in situ formed at wound site by tyrosinase‐triggered oxidation and self‐assembly of lyophilized antimicrobial peptide Trp‐Arg‐Trp‐Arg‐Trp‐Tyr, providing enhanced stability and a fourfold and sevenfold increasement in antibacterial efficiency against E. coli and S. aureus compared to peptide monomers. The antimicrobial peptide is first oxidized and then assembled into nanoparticles. The melanin‐like structure has been demonstrated with efficient antioxidant properties, and the experimental data show that peptide nanoparticles to scavenge superoxide radicals, hydroxyl radicals, and H2O2. In vivo experiments confirmed that peptide nanoparticles effectively heal infected wounds and obviously reduce ROS. Overall, the research provides a new approach to formulating antimicrobial peptides to treat wound with high healing efficiency.

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Intelligent design of polymersomes for antibacterial and anticancer applications

Wang

Qin

Cheng

et al. 2022

WIREs Nanomed Nanobiotechnol

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Polymersomes (or polymer vesicles) have attracted much attention for biomedical applications in recent years because their lumen can be used for drug delivery and their coronas and membrane can be modified with a variety of functional groups. Thus, polymersomes are very suitable for improved antibacterial and anticancer therapy. This review mainly highlighted recent advances in the synthetic protocols and design principles of intelligent antibacterial and anticancer polymersomes. Antibacterial polymersomes are divided into three categories: polymersomes as antibiotic nanocarriers, intrinsically antibacterial polymersomes, and antibacterial polymersomes with supplementary means including photothermal and photodynamic therapy. Similarly, the anticancer polymersomes are divided into two categories: polymersomes-based delivery systems and anticancer polymersomes with supplementary means. In addition, the bilateral relationship between bacteria and cancer is addressed, since more and more evidences show that bacteria may cause cancer or promote cancer progression. Finally, prospective on next-generation antibacterial and anticancer polymersomes are discussed.

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EGFR-targeted pemetrexed therapy of malignant pleural mesothelioma

Cited by 3 publications

References 34 publications

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

In Situ Enzyme‐Induced Self‐Assembly of Antimicrobial‐Antioxidative Peptides to Promote Wound Healing

Intelligent design of polymersomes for antibacterial and anticancer applications

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