EGFR-Mutated Breast Metastasis of Lung Adenocarcinoma: A Case Report

Abstract

Breast metastasis from other primary carcinoma is very rare and could be difficult to identify despite immunohistochemistry analysis. Breast metastasis from lung adenocarcinoma can mimic triple-negative breast cancer. Given the prognosis and therapeutic challenges, a correct diagnosis appears essential, and molecular biomarkers could be useful. We report the case of a 52-year-old woman with a breast mass initially diagnosed as primary breast cancer and secondarily attached to breast metastasis from an EGFR-mutated lung adenocarcinoma. The same activating EGFR mutations were identified in both the primary lung carcinoma and the breast metastasis.

Breast metastasis from EGFR‐mutated lung adenocarcinoma: A case report and review of the literature

“…Indeed, only 43 cases were identified in literature from 1989 to 2013 . Eighteen additional cases with detailed clinical information from 2013 to 2017 were identified in our literature search of the PubMed database (Table ) . Of these 18 cases, four involved male patients and 14 female patients, with ages ranging from 40 to 74 years (average, 56.5 years).…”

A Case of Lung Adenocarcinoma with Metastasis to the Breast

“…Few reports of EGFR mutated cases of lung adenocarcinomas with metastasis to the breast have been described and one case had a rapid and objective response of the primary and metastatic breast lesion to Afitinib, a TKI drug [8]. Our case received a combination of Erlotinib and bevacizumab that is identified superior to single agent Erlotinib in terms of progression free survival, but has a higher risk of grade 3 and 4 bleeding complications [25].…”

“…However, no clear predisposing factors have been identified for metastases to the breast. Since 1965 to 2014, 94 NSCLC tumors with metastasis to the breast are reported in the literature that included 30 cases of lung adenocarcinomas [4,5,8,10]. Metastasis to the breast is supposed to have poor prognoses [11].…”

“…The source of metastases to the breast are commonly hematologic malignancies, and melanomas [5][6][7]. Metastasis from lung adenocarcinoma to the breast is reported frequently in the literature and can mimic triple negative breast cancer, thus for an effective management, careful clinical and pathological differentiational diagnosis is required [8]. Various management strategies are used for stage IV NSCLCs with metastasis.…”