2014
DOI: 10.1038/ncb3031
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EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

Abstract: Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic inflammation and diverse signaling pathways including the Epidermal Growth Factor Receptor (EGFR) pathway. The precise role of EGFR in HCC is unknown, and EGFR-inhibitors have shown disappointing clinical results. Here we discover that EGFR is expressed in liver macrophages in both human HCC and in a mouse HCC model. Mice lacking EGFR in macrophag… Show more

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Cited by 205 publications
(216 citation statements)
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“…EGFR is vitally involved in regulating cell survival and proliferation [24, 25]. And in model systems of autocrine stimulation of EGFR, or EGFR overexpression and mutation, consequent transformation has been observed [26, 27].…”
Section: Discussionmentioning
confidence: 99%
“…EGFR is vitally involved in regulating cell survival and proliferation [24, 25]. And in model systems of autocrine stimulation of EGFR, or EGFR overexpression and mutation, consequent transformation has been observed [26, 27].…”
Section: Discussionmentioning
confidence: 99%
“…could be more efficiently generated after breeding to Nes‐Cre or GFAP‐Cre mice. Genotyping was performed by PCR as previously described 19, 72. Primer sequences can be obtained upon request.…”
Section: Methodsmentioning
confidence: 99%
“…Therefore, it should be noted that more studies are needed to elucidate the roles of EGFR activation in macrophages in inflammation-associated tumorigenesis. In fact, EGFR in macrophages in liver has shown tumor-promoting effects on hepatocellular carcinoma formation induced by diethylnitrosamine/phenobarbital (39). In this model, IL-1␤, released by DEN-damaged hepatocytes, stimulates Kupffer cells to produce IL-6.…”
Section: Journal Of Biological Chemistry 20467mentioning
confidence: 99%