EGFR aptamer-conjugated liposome-polycation-DNA complex for targeted delivery of SATB1 small interfering RNA to choriocarcinoma cells

Dong, Jinhua; Cao, Yunfei; Shen, Huaxiang; Ma, Qiang; Mao, Shuhui; Li, Suping; Sun, Jin

doi:10.1016/j.biopha.2018.08.042

Cited by 27 publications

(8 citation statements)

References 25 publications

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“… The publication of this work enlightened researchers toward further improvements in the targeted delivery of siRNA using nanoassemblies and DNA nanotechnology. In combination with other nanodelivery systems, such as lipid nanoparticles (LNPs) and exosomes, aptamers can significantly improve the efficiency of drug delivery by “coordinating” with other delivery systems. − The design of aptamer-functionalized LNPs is shown in Figure a. Liang et al used cell-SELEX to select aptamer CH6 that specifically targets both rat and human osteoblasts.…”

Section: Aptamer-based Sirna Targeted Deliverymentioning

confidence: 99%

Aptamer-Based Targeted Delivery of Functional Nucleic Acids

Xie

Sun

et al. 2023

J. Am. Chem. Soc.

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Functional nucleic acid (NA)-based drugs have a broad range of applications since they allow the alteration and control of gene/protein expression patterns in cells. In principle, functional NAs need to be transported precisely and efficiently to target cells to guarantee both functionality and safety. Owing to their negative charges, it is difficult for natural NAs to cross the cell membrane composed of lipid bilayer and enter targeted cells. Worse still, the delivery of undirected functional NAs to nontargeted healthy cells and/or tissues would induce unpredictable adverse effects. Therefore, the precisely targeted delivery of functional NAs to specific cells/organs, particularly in extrahepatic sites, is required. Since aptamers can bind to various proteins on the cell surface with high specificity and selectivity, they can serve as the molecular recognition units to accurately bind target cells and subsequently enable the efficient delivery of cargo. In this perspective, we summarize the original, proof-of-concept aptamer-based strategies for the targeted delivery of functional NAs. A few specific examples are then discussed, followed by our perspectives on some of the challenges and opportunities that lie ahead.

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Section: Aptamer-based Sirna Targeted Deliverymentioning

confidence: 99%

Aptamer-Based Targeted Delivery of Functional Nucleic Acids

Xie

Sun

et al. 2023

J. Am. Chem. Soc.

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“…This delivery system’s ability to specifically target choriocarcinoma cells, drastically lower SATB1 expression, induce tumor growth inhibition, and further cause the death of EGFR-overexpressing choriocarcinoma cells has been demonstrated in cell lines. Importantly, SATB1 expression was suppressed by this gene delivery system in mouse choriocarcinoma xenografts with a tumor weight inhibition rate of 81.4% [ 123 ].…”

Section: Dna-based Materialsmentioning

confidence: 99%

DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors

Shishparenok

Furman

Zhdanov

2023

Cancers

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DNA nanotechnology has significantly advanced and might be used in biomedical applications, drug delivery, and cancer treatment during the past few decades. DNA nanomaterials are widely used in biomedical research involving biosensing, bioimaging, and drug delivery since they are remarkably addressable and biocompatible. Gradually, modified nucleic acids have begun to be employed to construct multifunctional DNA nanostructures with a variety of architectural designs. Aptamers are single-stranded nucleic acids (both DNAs and RNAs) capable of self-pairing to acquire secondary structure and of specifically binding with the target. Diagnosis and tumor therapy are prospective fields in which aptamers can be applied. Many DNA nanomaterials with three-dimensional structures have been studied as drug delivery systems for different anticancer medications or gene therapy agents. Different chemical alterations can be employed to construct a wide range of modified DNA nanostructures. Chemically altered DNA-based nanomaterials are useful for drug delivery because of their improved stability and inclusion of functional groups. In this work, the most common oligonucleotide nanomaterials were reviewed as modern drug delivery systems in tumor cells.

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“…The liposome is coupled to an aptamer that can target EGFR, allowing efficient siRNA delivery to mice with high EGFR protein expression. 147 Ahmad et al developed a novel cationic cardiolipin analog (CCLA)-based liposome to deliver C-Raf siRNA. In vitro delivery of C-Raf siRNA resulted in 62% C-Raf gene silencing and 73% tumor growth inhibition in mice.…”

Section: Liposomal and Polymer Nano-vehicles For Rna Deliverymentioning

confidence: 99%