EGF +61A&gt;G polymorphism and gastrointestinal cancer risk: A HuGE review and meta-analysis

Piao, Ying; Liu, Zhaozhe; Ding, Zhenyu; Xu, Long; Guo, Fang; Sun, Qingqing; Xie, Xiaodong

doi:10.1016/j.gene.2013.01.057

Cited by 13 publications

(10 citation statements)

References 31 publications

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“…Epidermal growth factor (EGF) has many biological functions, including stimulation of cell proliferation and differentiation of specific cells . Recent studies have reported that the single‐nucleotide polymorphism (SNP) A to G mutation at position 61 of the 5′ untranslated region of the EGF gene (rs4444903) is associated with an increased risk of various malignant tumors . In patients with HCC, this 61*G polymorphism is associated with an increased risk of hepatocarcinogenesis in patients with chronic hepatitis C virus (HCV) infection and advanced fibrosis .…”

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confidence: 99%

“…(7,8) Recent studies have reported that the single-nucleotide polymorphism (SNP) A to G mutation at position 61 of the 5 0 untranslated region of the EGF gene (rs4444903) is associated with an increased risk of various malignant tumors. (9)(10)(11) In patients with HCC, this 61*G polymorphism is associated with an increased risk of hepatocarcinogenesis in patients with chronic hepatitis C virus (HCV) infection and advanced fibrosis. (12) A meta-analysis found that this polymorphism was a risk factor for HCC in a cohort of inhomogeneous patients, (13) whereas another study found that it was not a risk factor for HCC in patients with chronic hepatitis B virus infection.…”

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Impact of epidermal growth factor single‐nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection

et al. 2014

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Epidermal growth factor (EGF) gene single-nucleotide polymorphism (SNP) is associated with an increased risk of hepatic tumors. The study aimed to elucidate the impact of EGF SNP and EGF receptor (EGFR) expression on the recurrence of hepatocellular carcinoma (HCC) after hepatectomy. To examine the impact of EGF SNP and EGFR on recurrent HCC, we retrospectively analyzed 141 HCC patients with chronic hepatitis C virus infection who underwent curative hepatectomy. The EGF *61 GG allele was present in 69 patients (48.9%), AG in 56 (39.7%) and AA in 16 (11.4%). The AA group had a significantly lower rate of intrahepatic metastasis (0% vs 16.5%, P = 0.02), lower serum EGF concentration (26.3 ± 15.9 pg/mL vs 43.4 ± 30.5 pg/mL, P = 0.02) and lower proportion of early recurrence (≤2 years; 28.6% vs 71.2%, P = 0.03) than the AG/GG group. The AA group had significantly higher recurrence-free survival than the AG/GG group (P = 0.04), but there was no significant difference in overall survival between these two groups (P = 0.97). High versus low EGFR expression analyzed by immunohistochemical staining in cancer cells was not significantly associated with overall survival (P = 0.37) or recurrence-free survival (P = 0.39). Therefore, EGF *61 AA was associated with a lower risk of recurrence after curative hepatectomy for HCC in patients with hepatitis C virus infection than other genotypes, but EGFR expression in cancer cells was not significantly associated with prognosis.

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Impact of epidermal growth factor single‐nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection

et al. 2014

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“…However, in Caucasian populations, the AA genotype was found in higher frequency than its GG counterpart (Shahbazi et al, 2002;Vauleon et al, 2007;Lanuti et al, 2008). According to two different meta-analyses on the association between the EGF promoter variant and cancer risk, the EGF +61 A>G polymorphism was proposed to be correlated with an increased risk of gastric, esophageal, and colorectal cancers, as well as glioma (Zhang et al, 2010;Piao et al, 2013). The GG genotype was reported to be significantly associated to CRC susceptibility among Caucasians (Wu et al, 2009).…”

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confidence: 99%

Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population

Lau¹,

Roslani²,

Lian³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Growth factors are polypeptides that are critical for the initiation, progression, and metastasis of cancer. Most tumor cells are capable of synthesizing particular growth factors leading to constitutive pathway activation in these cells through autocrine signaling. Epidermal growth factor (EGF) is a potent mitogenic peptide that exerts direct effects on the proliferation and differentiation of tumor cells in carcinogenesis. By contrast, vascular endothelial growth factor (VEGF) is vital for the invasion and metastasis of neoplasms through the formation of new blood vessels from mature endothelial cells. In this study, we investigated the association between functional polymorphisms of both the EGF and VEGF genes and colorectal cancer (CRC) susceptibility. A total of 130 CRC patients and 212 healthy controls were recruited for this case-control study. Genotyping of genetic variants was conducted via real-time polymerase chain reaction (PCR) amplification with allelespecific TaqMan probes. None of the genotypes of the EGF +61 A>G and VEGF +936 C>T variants was significantly associated with CRC susceptibility among the Malaysian subjects evaluated (P > 0.05). The observed frequency distributions of the EGF +61 A>G polymorphism genotypes showed ethnic heterogeneity, which was not the case for the VEGF +936 C>T genotypes. In conclusion, no positive correlation between these functional polymorphisms and CRC risk was found in this Malaysian population. Studies of the EGF and VEGF genes and CRC susceptibility are scarce, and the results reported thus far differ from one population to another. Hence, more replication studies are warranted before any firm conclusions can be made.

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“…Traditionally-known factors such as lifestyle and diet account for a significant proportion of digestive system cancer susceptibility, but the is much that remains unknown (Desauw, 2010). With recent developments in molecular biology, researchers provide strong evidence that genetic factors such as the epidermal growth factor gene and phospholipase C epsilon 1 gene are also important in the pathogenesis of gastrointestinal cancer (Piao et al, 2013;Hao et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Association between the -607 C > A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis

Yao

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The interleukin-18 (IL-18) gene -607 C/A polymorphism has been reported to be associated with gastrointestinal cancer, but there are conflicting results from previous studies on said topic. Therefore, the aim of this meta-analysis is to derive a more precise estimation of the association between the -607 C/A polymorphism in the IL-18 gene and gastrointestinal cancer risk. Literature searches of PubMed, Google Scholar, and Web of Science databases were carried out in 2015. Five studies were assessed with a total of 1618 cases and 1155 healthy controls. When results from all eligible studies were pooled into the meta-analysis, we found significant association between the IL-18 gene -607 C/A polymorphism In the subgroup analysis, significant associations between the -607 C/A polymorphism and gastrointestinal cancer risk were found in esophageal cancer. However, this polymorphism did not appear to have any influence on gastric cancer and colorectal cancer susceptibility. In conclusion, this meta-analysis suggests that the -607 C/A polymorphism in the IL-18 gene may be associated with susceptibility to esophageal cancer. Further studies with large sample sizes are needed to confirm these conclusions.

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EGF +61A>G polymorphism and gastrointestinal cancer risk: A HuGE review and meta-analysis

Cited by 13 publications

References 31 publications

Impact of epidermal growth factor single‐nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection

Impact of epidermal growth factor single‐nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection

Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population

Association between the -607 C > A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis

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