Association between the -607 C &gt; A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis

Yao, Jun; Li, Z H; Li, Y X; R, Zhang; Zhang, D G; Xu, Zheng; Wang, L S; Wang, J Y

doi:10.4238/2015.december.14.15

Cited by 6 publications

(3 citation statements)

References 21 publications

(21 reference statements)

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“…Instead, they collated data from several laboratories whose different platforms, protocols and data processing procedures question the significance (e.g. [8][9][10][11][12][13])…”

Section: Introductionmentioning

confidence: 99%

Towards a Personalized Cancer Gene Therapy: A Case of Clear Cell Renal Cell Carcinoma

Iacobaş¹,

Iacobaş²

2017

cor

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An ideal cancer gene therapy would selectively destroy the cancer nodules with negligible effects on the surrounding not yet compromised tissue. This would be possible if the targeted genes are in command positions in the cancer but not in the normal cells. Logic dictates that, while being strongly protected by the homeostatic mechanisms, expression of a commander gene governs most major functional pathways by regulating the expression of numerous other genes. Owing to the cancer dependence on race, sex, age, genetic heritage, medical history, environmental and lifestyle associated risk factors each patient has most likely a distinct, dynamic and never repeatable set of commander genes. Here we introduce the "gene commanding height" as a measure of gene rank in the cell hierarchy and test our procedure on a surgically removed metastatic clear cell renal cell carcinoma. Results indicate that each histopathologically distinct region has a unique set of commander genes and that cancer cell commanders are in low positions in normal cells. We believe that the genomic oncology should identify the cancer cell commander genes of the individual patient instead of testing for the biomarkers selected from most frequently altered genes in large populations.

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“…Instead, they collated data from several laboratories whose different platforms, protocols and data processing procedures question the significance (e.g. [8][9][10][11][12][13])…”

Section: Introductionmentioning

confidence: 99%

Towards a Personalized Cancer Gene Therapy: A Case of Clear Cell Renal Cell Carcinoma

Iacobaş¹,

Iacobaş²

2017

cor

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“…Previous studies have indicated an association between IL18-607C/A and -137G/ C polymorphisms and the risk of many malignant tumors, such as esophageal cancer, gastrointestinal cancer, papillary thyroid cancer, hepatocellular carcinoma, prostate carcinoma, and oral squamous cell carcinoma (Liu et al, 2013;Singh et al, 2014;Bao et al, 2015;Chung et al, 2015;Dwivedi et al, 2015b;Li et al, 2015;Yao et al, 2015;Zhu et al, 2016). Singh et al (2014) performed a study on 272 patients with oral squamous cell carcinoma and 185 controls, and reported that the IL18-137G/C genetic variation was correlated with the progression of this cancer, but the -607C/A polymorphism was not.…”

Section: Discussionmentioning

confidence: 99%

“…Dwivedi et al (2015b) found that individuals harboring the GG genotype of IL18 could be diagnosed at an earlier stage than those with the CC genotype. Yao et al (2015) examined five studies comprising 1618 patients and 1155 healthy controls, and reported that the IL18-607C/A polymorphism was associated with a higher risk of esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population

Wei

Zhang

et al. 2016

Genet. Mol. Res.

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Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression of interferon-γ and TNF-α in humans. IL18 is therefore involved in the elimination of tumor cells in the human body. We recruited 357 patients with non-small cell lung cancer (NSCLC) and 414 controls to evaluate the correlation between two genetic variations (IL18-607C/A and IL18-137G/C) and the pathogenesis of NSCLC. We used polymerase chain reaction-restriction fragment length polymorphism to genotype IL18-607C/A and IL18-137G/C. Statistical analysis revealed that individuals harboring the AA genotype of IL18-607C/A had an increased risk of NSCLC compared to those harboring the CC genotype (OR = 2.20, 95%CI = 1.30-3.74). Individuals expressing the A allele of IL18-607C/A had an elevated risk of developing NSCLC compared to those expressing the C allele (OR = 1.31, 95%CI = 1.06-1.62). In summary, our analysis shows that the IL18-607C/A genetic variation is related to the risk of NSCLC, whereas the IL18-137G/C variation is not. Therefore, the IL18-607C/A variation is related to the pathogenesis of NSCLC in the Chinese population studied.

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Gastric Tumorigenesis: Role of Inflammation and Helicobacter pylori

Zanussi

Casarotto

Pratesi

et al. 2019

Current Clinical Pathology

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Association between the -607 C > A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis

Cited by 6 publications

References 21 publications

Towards a Personalized Cancer Gene Therapy: A Case of Clear Cell Renal Cell Carcinoma

Towards a Personalized Cancer Gene Therapy: A Case of Clear Cell Renal Cell Carcinoma

Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population

Gastric Tumorigenesis: Role of Inflammation and Helicobacter pylori

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