EGCG/Zn coating on titanium implants by one-step hydrothermal method for improving anticorrosion, antibacterial and osteogenesis properties

Zhong, Yongcong; Wang, Shuoqi; Tian, Liangjie; Wang, Xiaojian; Hu, Yanjun; Xie, Mingyang

doi:10.1016/j.matchemphys.2022.126872

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…The promotion of bone formation and inhibition of osteoclast activity make EGCG a potential game-changer in the field of dental implants. While previous research has explored the effects of EGCG on various implant materials, including titanium implants [ 15 ] and bone graft materials [ 47 ], the novelty of this study lies in its focus on PEEK—a material with unique challenges and opportunities and also on the novel coating technique for EGCG.…”

Section: Discussionmentioning

confidence: 99%

“…EGCG, the star of this study, has attracted attention for its diverse biological activities, ranging from antioxidant and anti-inflammatory properties to bonestimulating effects [45,46]. The promotion of bone formation and inhibition of osteoclast activity make EGCG a While previous research has explored the effects of EGCG on various implant materials, including titanium implants [15] and bone graft materials [47], the novelty of this study lies in its focus on PEEK-a material with unique challenges and opportunities and also on the novel coating technique for EGCG. While the in vitro results provide compelling evidence for the potential of EGCG-coated PEEK implants, the dynamic and multifaceted environment within the human body poses unique challenges.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, EGCG has been reported to promote bone formation and inhibit osteoclast activity, making it a promising candidate for improving the osseointegration of dental implants [14]. Several studies have investigated the effects of EGCG coating on dental and biomedical materials like titanium or other types of alloys and even some polymers [15][16][17][18]. However, to the best of our knowledge, no studies have investigated the effects of pure EGCG coating on the properties of PEEK.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of High-Performance Polyether Ether Ketone Polymer Treated with Piranha Solution and Epigallocatechin-3-Gallate Coating

Alsmael,

Al-Khafaji

2024

BioMed Research International

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Background. Dental implantation has become a standard procedure with high success rates, relying on achieving osseointegration between the implant surface and surrounding bone tissue. Polyether ether ketone (PEEK) is a promising alternative to traditional dental implant materials like titanium, but its osseointegration capabilities are limited due to its hydrophobic nature and reduced surface roughness. Objective. The aim of the study is to increase the surface roughness and hydrophilicity of PEEK by treating the surface with piranha solution and then coating the surface with epigallocatechin-3-gallate (EGCG) by electrospraying technique. Materials and Methods. The study includes four groups intended to investigate the effect of piranha treatment and EGCG coating: a control group of PEEK discs with no treatment (C), PEEK samples treated with piranha solution (P), a group of PEEK samples coated with EGCG (E), and a group of PEEK samples treated with piranha solution and coated with EGCG (PE). Surface roughness, wettability, and microhardness were assessed through statistical analysis. Results. Piranha treatment increased surface roughness, while EGCG coating moderated it, resulting in an intermediate roughness in the PE group. EGCG significantly improved wettability, as indicated by the reduced contact angle. Microhardness increased by about 20% in EGCG-coated groups compared to noncoated groups. Statistical analysis confirmed significant differences between groups in all tests. Conclusion. This study demonstrates the potential of EGCG coating to enhance the surface properties of PEEK as dental implants. The combined piranha and EGCG modification approach shows promise for improved osseointegration, although further vivo research is necessary. Surface modification techniques hold the key to optimizing biomaterial performance, bridging the gap between laboratory findings and clinical implementation in dental implantology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of High-Performance Polyether Ether Ketone Polymer Treated with Piranha Solution and Epigallocatechin-3-Gallate Coating

Alsmael,

Al-Khafaji

2024

BioMed Research International

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“…The Ti surface is covered with another material, which can change the composition of the implant surface to a greater extent and achieve more excellent biomedical functions. Coating technologies include plasma spraying, , nanospray drying, sol–gel method, , hydrothermal method, , self-assembly method, , 3D printing, and so on.…”

Section: Surface Modification Techniques For Dental Implantsmentioning

confidence: 99%

Surface Modification and Functionalities for Titanium Dental Implants

Sun,

Liu,

Wang

et al. 2023

ACS Biomater. Sci. Eng.

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Dental implants have become the mainstream strategy for oral restoration, and implant materials are the most important research hot spot in this field. So far, Ti implants dominate all kinds of implants. The surface properties of the Ti implant play decisive roles in osseointegration and antibacterial performance. Surface modifications can significantly change the surface micro/nanotopography and composition of Ti implants, which will effectively improve their hydrophilicity, mechanical properties, osseointegration performance, antibacterial performance, etc. These optimizations will thus improve implant success and service life. In this paper, the latest surface modification techniques of Ti dental implants are systematically and comprehensively reviewed. The various biomedical functionalities of surface modifications are discussed in-depth. Finally, a profound comment on the challenges and opportunities of this frontier is proposed, and the most promising directions for the future were explored.

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“…Studies have shown that EGCG can synergize with numerous metal ions to form a metal polyphenol network. Zinc ions (Zn 2+ ) have been reported to have the ability to promote angiogenesis, cell proliferation and migration, whereas the complexation of EGCG with Zn 2+ can further enhance its stability and antimicrobial activity [28][29][30]. While injectable hydrogels can serve as a suitable delivery matrix for further prolonging the duration of action of EGCG in the sustained wound treatment [31,32].…”

Section: Introductionmentioning

confidence: 99%

Injectable hydrogel with antimicrobial and anti-inflammatory properties for postoperative tumor wound care

Li,

Xing,

Bai

et al. 2024

Biomed. Mater.

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Clinically, tumor removal surgery leaves irregularly shaped wounds that are susceptible to bacterial infection and further lead to excessive inflammation. Injectable hydrogel dressings with antimicrobial and anti-inflammatory properties have been recognized as an effective strategy to care for postoperative tumor wounds and prevent recurrence in recent years. In this work, we constructed a hydrogel network by ionic bonding interactions between quaternized chitosan (QCS) and EGCG-Zn complexes which were coordinated by epigallocatechin gallate (EGCG) and zinc ions (Zn2+). Because of the synergistic effect of QCS and EGCG-Zn, the hydrogel exhibited outstanding antimicrobial capacity (>99.9% inhibition), which could prevent infections caused by Escherichia coli and Staphylococcus aureus. In addition, the hydrogel was able to inhibit the growth of mice breast cancer cells (56.81% survival rate within 72 h) and reduce inflammation, which was attributed to the sustained release of EGCG. The results showed that the hydrogel was effective in inhibiting tumor recurrence and accelerating wound closure when applied to the postoperative tumor wounds. This study provided a simple and reliable strategy for postoperative tumor wound care using antimicrobial and anti-inflammatory injectable dressings, confirming their great potential in the field of postoperative wound dressings.

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EGCG/Zn coating on titanium implants by one-step hydrothermal method for improving anticorrosion, antibacterial and osteogenesis properties

Cited by 6 publications

References 39 publications

Evaluation of High-Performance Polyether Ether Ketone Polymer Treated with Piranha Solution and Epigallocatechin-3-Gallate Coating

Evaluation of High-Performance Polyether Ether Ketone Polymer Treated with Piranha Solution and Epigallocatechin-3-Gallate Coating

Surface Modification and Functionalities for Titanium Dental Implants

Injectable hydrogel with antimicrobial and anti-inflammatory properties for postoperative tumor wound care

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