EGb761 attenuates depressive-like behaviours induced by long-term light deprivation in C57BL/6J mice through inhibition of NF-κB-IL-6 signalling pathway

Zhang, Yongdong; Zhao, Yuehan; Pan, Fang; Zhang, Panmin

doi:10.5114/ceji.2016.63807

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…Increased oxidative stress and reduced BDNF expression and/or function, particularly in the hippocampus, have also been implicated in both the pathophysiology of major depression and the typical overreaction to stress ( 169 , 170 ). Confirming light-deprived animals as a model of depression, DD was shown to aggravate the outcome of oxidative stress, as shown by proinflammatory processes in the hippocampus ( 159 , 163 ) which impaired neural plasticity and neurogenesis resulting in a subsequent deficit of learning ( 154 ), susceptibility to stress ( 152 ), and reduced c-Fos and CREB expression in several limbic areas involved in the reward and motivation mechanism ( 171 ). The depressive behavioral phenotype, inflammatory profile, and associated hippocampal neurodegeneration correlated with the DNA methylation–related chromatin remodeling process ( 172 ) that regulates neuronal activity dependent of BDNF gene expression ( 173 ).…”

Section: Constant Darknessmentioning

confidence: 94%

Dim Light at Night and Constant Darkness: Two Frequently Used Lighting Conditions That Jeopardize the Health and Well-being of Laboratory Rodents

González¹

2018

Front. Neurol.

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The influence of light on mammalian physiology and behavior is due to the entrainment of circadian rhythms complemented with a direct modulation of light that would be unlikely an outcome of circadian system. In mammals, physiological and behavioral circadian rhythms are regulated by the suprachiasmatic nucleus (SCN) of the hypothalamus. This central control allows organisms to predict and anticipate environmental change, as well as to coordinate different rhythmic modalities within an individual. In adult mammals, direct retinal projections to the SCN are responsible for resetting and synchronizing physiological and behavioral rhythms to the light-dark (LD) cycle. Apart from its circadian effects, light also has direct effects on certain biological functions in such a way that the participation of the SCN would not be fundamental for this network. The objective of this review is to increase awareness, within the scientific community and commercial providers, of the fact that laboratory rodents can experience a number of adverse health and welfare outcomes attributed to commonly-used lighting conditions in animal facilities during routine husbandry and scientific procedures, widely considered as “environmentally friendly.” There is increasing evidence that exposure to dim light at night, as well as chronic constant darkness, challenges mammalian physiology and behavior resulting in disrupted circadian rhythms, neural death, a depressive-behavioral phenotype, cognitive impairment, and the deregulation of metabolic, physiological, and synaptic plasticity in both the short and long terms. The normal development and good health of laboratory rodents requires cyclical light entrainment, adapted to the solar cycle of day and night, with null light at night and safe illuminating qualities during the day. We therefore recommend increased awareness of the limited information available with regards to lighting conditions, and therefore that lighting protocols must be taken into consideration when designing experiments and duly highlighted in scientific papers. This practice will help to ensure the welfare of laboratory animals and increase the likelihood of producing reliable and reproducible results.

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Section: Constant Darknessmentioning

confidence: 94%

Dim Light at Night and Constant Darkness: Two Frequently Used Lighting Conditions That Jeopardize the Health and Well-being of Laboratory Rodents

González¹

2018

Front. Neurol.

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“…Экспериментальные [50,51], а затем клинические [52,53] исследования показали способность EGb761 улучшать симптомы депрессии и тревоги, в том числе за счет модуляции секреции дофамина и серотонина в головном мозге. ИР головного мозга является значимым звеном патогенеза дегенеративных и метаболических заболеваний головного мозга.…”

Section: обзорыunclassified

Cerebral insulin resistance: current concepts of the pathogenesis and possible therapeutic strategies

Esin

Хайруллин

Esin

2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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The review presents current concepts about the problem of cerebral insulin resistance (IR). It has now been established that cerebral IR plays a key role in the pathogenesis of degenerative and metabolic diseases of the brain. Based on literature data and own clinical experience, the authors recommend to use the standardized extract of ginkgo biloba EGb761 as a cellular protector, which increases insulin sensitivity of cells and reduces atherogenesis, in order to improve cognitive functions and quality of life in patients with diabetes mellitus.

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“…Our findings strongly support that light deprivation could well produce a depression-like behavior mouse model, and highlights the changes in motor cortical neural microcircuit induced by light deprivation being a potential mechanism underlying depression. The other possible underlying mechanism of light deprivation inducing depressive-like phenotypes is that light deprivation could change some inflammatory cytokines related to depression [30]. There are some evidence showing inflammatory cytokines playing some roles in depression [31][32][33], and some inflammatory cytokines were especially increased in patients with depression [34,35].…”

Section: Introductionmentioning

confidence: 99%

Light deprivation: An efficient way in inducing depression-like behavior animal models

Lu¹,

Lin²,

Li³

et al. 2017

Res Rev Insights

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Depression as one kind of neuropsychiatric disorder leads to great burden to both the economy and society worldwide. A great number of animal models of depression emerge with an aim to unveil the underlying pathophysiological mechanism of this serious mental illness. Among of these animal models, depression-like behavior model induced by light deprivation is of great interest to us. However, the current state of knowledge concerning this kind of animal model of depression has been relatively few to date. In the current review, we concisely summarized some key historic and recent studies related to depressive-like phenotypes induced by light deprivation, and emphasized the importance of this efficient, convenient as well as inexpensive method in producing depression-like behavior animal models. Moreover, it was highlighted that light therapy when combined with some other antidepressant treatment was much more powerful and efficient. Last but not the least, much more efforts were also made to outline the possible mechanisms underlying how light deprivation producing the depressive-like phenotypes in animal models, in order to shed some light on the future studies on depression.

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EGb761 attenuates depressive-like behaviours induced by long-term light deprivation in C57BL/6J mice through inhibition of NF-κB-IL-6 signalling pathway

Cited by 5 publications

References 41 publications

Dim Light at Night and Constant Darkness: Two Frequently Used Lighting Conditions That Jeopardize the Health and Well-being of Laboratory Rodents

Dim Light at Night and Constant Darkness: Two Frequently Used Lighting Conditions That Jeopardize the Health and Well-being of Laboratory Rodents

Cerebral insulin resistance: current concepts of the pathogenesis and possible therapeutic strategies

Light deprivation: An efficient way in inducing depression-like behavior animal models

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