Efinaconazole nail lacquer for the transungual drug delivery: Formulation, optimization, characterization and in vitro evaluation

Aggarwal, Remica; Targhotra, Monika; Sahoo, Prabhat K.; Chauhan, Meenakshi Kanwar

doi:10.1016/j.jddst.2020.101998

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…The viscosity of the test and control lacquers were found to be a 50.7 ± 4.6 cP and 41.3 ± 6.1 cP, respectively, consistent with similar products made previously [ 51 ]. This provides the lacquer with the desirable consistency to spread easily on the nail and form the fast-drying film.…”

Section: Resultssupporting

confidence: 88%

“…The pilot experiments were performed to screen whether a combination of polymers in a hydroalcoholic solvent system would be suitable for the purposes of our research as such a system has been reported previously in the literature, stating beneficial properties of the resultant lacquer, such as capability to hydrate the nail with the hydrophilic component while achieving desirable physical characteristics of the lacquer such as resistance and adhesion with the hydrophobic component [ 51 ]. Even bilayered systems have been reported to have similar benefits with a hydrophilic and hydrophobic coat of the lacquers applied separately [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…After 24 h, the slides were removed and were patted dry using lint-free wipes to be weighed again. The loss in weight of the lacquer as a percentage of the original film weight was reported as a measure of its water resistance as shown in Equation (4) [ 51 , 52 ].

…”

Section: Methodsmentioning

confidence: 99%

“…Adhesion testing was performed on the lacquers using previously published methodology [ 51 , 53 ]. Using a pipette, a 10 µL drop of the lacquer was applied on glass slide and allowed to dry completely.…”

Section: Methodsmentioning

confidence: 99%

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Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate

et al. 2022

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The fungal disease of the nail, onychomycosis, which is also the most prevalent nail disturbance, demands effective topical treatment options considering the possible adverse effects of systemic antifungal therapy. The current work is focused on development of an adhesive and resistant, drug-delivering and permeation-enhancing polymeric film containing econazole nitrate (ECN) for topical antifungal treatment. The development of the lacquer formulation was guided by the Quality by Design approach to achieve the critical quality attributes needed to obtain the product of desired quality. Eudragit RSPO at 10% w/w was found to be the ideal adhesive polymer for the application and an optimal permeation-enhancing lacquer formulation was achieved by the optimization of other formulation excipients, such as plasticizer and the solvent system. Additionally, novel experimental enhancements introduced to the research included refined D50 drying time and drying rate tests for lacquer characterization as well as a multi-mechanism permeation-enhancing pre-treatment. Moreover, a practical implication was provided by a handwashing simulation designed to test the performance of the lacquer during actual use. In vitro drug release testing and ex vivo nail permeation testing demonstrated that the optimized nail lacquer performed better than control lacquer lacking the permeation enhancer by achieving a faster and sustained delivery of ECN. It can be concluded that this is a promising drug delivery system for topical antifungal treatment of onychomycotic nails, and the novel characterization techniques may be adapted for similar formulations in the future.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate

et al. 2022

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“…Similar lacquers were developed in sulfur, silicon, and biotin supplements to treat nail inflammatory disorders ( Fernandez-Campos et al., 2020 ). The release of drugs is affected by the characteristics and concentration of the film former, plasticizer, solvent, and drug ( Sveikauskaite and Briedis, 2017 ; Cutrin-Gomez et al., 2018 ; Valdes et al., 2018 ; Aggarwal et al., 2020a ). Interactions between drug and film-forming systems reduce the release or inactivation and hence should be avoided in quick delivery systems ( Sveikauskaite and Briedis, 2017 ).…”

Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Guo

et al. 2023

Front. Cell. Infect. Microbiol.

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Fungal diseases have posed a great challenge to global health, but have fewer solutions compared to bacterial and viral infections. Development and application of new treatment modalities for fungi are limited by their inherent essential properties as eukaryotes. The microorganism identification and drug sensitivity analyze are limited by their proliferation rates. Moreover, there are currently no vaccines for prevention. Polymer science and related interdisciplinary technologies have revolutionized the field of fungal disease management. To date, numerous advanced polymer-based systems have been developed for management of fungal diseases, including prevention, diagnosis, treatment and monitoring. In this review, we provide an overview of current needs and advances in polymer-based strategies against fungal diseases. We high light various treatment modalities. Delivery systems of antifungal drugs, systems based on polymers’ innate antifungal activities, and photodynamic therapies each follow their own mechanisms and unique design clues. We also discuss various prevention strategies including immunization and antifungal medical devices, and further describe point-of-care testing platforms as futuristic diagnostic and monitoring tools. The broad application of polymer-based strategies for both public and personal health management is prospected and integrated systems have become a promising direction. However, there is a gap between experimental studies and clinical translation. In future, well-designed in vivo trials should be conducted to reveal the underlying mechanisms and explore the efficacy as well as biosafety of polymer-based products.

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The precursors of AI adoption in business: Towards an efficient decision-making and functional performance

Baabdullah

2024

International Journal of Information Management

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Efinaconazole nail lacquer for the transungual drug delivery: Formulation, optimization, characterization and in vitro evaluation

Cited by 7 publications

References 25 publications

Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate

Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate

Progress of polymer-based strategies in fungal disease management: Designed for different roles

The precursors of AI adoption in business: Towards an efficient decision-making and functional performance

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