Eficacia de las infiltraciones con ozono en el tratamiento de la osteoartritis de rodilla vs. otros tratamientos intervencionistas: revisión sistemática de ensayos clínicos

Arias‐Vázquez, Pedro Iván; Tovilla-Zárate, Carlos Alfonso; Bermúdez-Ocaña, Deysi Y.; Legorreta-Ramírez, Blanca Gabriela; López‐Narváez, María Lilia

doi:10.1016/j.rh.2018.11.001

Cited by 9 publications

(14 citation statements)

References 33 publications

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“…The use of intra-articular ozone (O2-O3) has proven to be a safe treatment, without adverse effects and capable of objectively improving clinical, laboratory, and radiological biomarkers, as it has been in the case of our patient with bilateral knee osteoarthritis. Therefore, we agree with Arias-Vazquez et al and Nori-Zadehh et al who, in two recent systematic reviews and meta-analyzes, believe that ozone (O2-O3) should be considered as a therapeutic alternative for the management of knee osteoarthritis [10,11].…”

Section: Discussionsupporting

confidence: 90%

Symptomatic (Pain and Inflammation) and Disease-Modifying Effect (Minimal Joint Space) of Intra-articular Ozone (O2-O3) in Osteoarthritis of the Knee: a Clinical Case

Fernández-Cuadros

Pérez-Moro

Albaladejo-Florín

et al. 2019

SN Compr. Clin. Med.

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The objective of the clinical case is to report the symptomatic effect and, for the first time, the disease-modifying effect of ozone in a patient with osteoarthritis of the knee. A 67-year-old woman has been infiltrated with ozone 1 time/week for 4 weeks, using an oxygen-ozone volume of 20 ml, at a 20-µg/ml concentration. Another cycle of ozone treatment was boosted at 6 months follow-up. Clinical outcomes such as pain, function, and quality of life were measured by the Western Ontario and McMaster University Index for Osteoarthritis (WOMAC) scale. Biochemical markers of inflammation such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and uric acid were performed at the beginning and at the end of ozone (O2-O3) treatment protocol. Radiological outcome was evaluated as the change in minimal joint space at the medial compartment of joint space, at the beginning and at 12 months follow-up in both knees. In the first and second ozone cycles, clinical (pain, function, rigidity) and biochemical variables (CRP, ESR, uric acid) improved in our case report. Minimal joint space at medial compartment improved in both knees after 12 months follow-up. Intra-articular ozone (O2-O3) has shown a symptomatic effect and especially a disease-modifying effect in a patient with knee osteoarthritis, improving pain, function, and rigidity; decreasing inflammation biomarkers (CRP, ESR, and uric acid); and increasing the joint space of the medial component evidenced radiologically. The structural effect is reported for the first time in literature. No adverse effects have been observed after intra-articular ozone infiltrations.

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Section: Discussionsupporting

confidence: 90%

Symptomatic (Pain and Inflammation) and Disease-Modifying Effect (Minimal Joint Space) of Intra-articular Ozone (O2-O3) in Osteoarthritis of the Knee: a Clinical Case

Fernández-Cuadros

Pérez-Moro

Albaladejo-Florín

et al. 2019

SN Compr. Clin. Med.

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“…y Vázquez y cols. han definido al ozono (O 2 -O 3 ) como una opción válida para el manejo de la OA de rodilla debido a su efectividad en el manejo de dolor (45,46). En el caso del PRP, tres metanálisis recientes (Chang 2013, Khoshbin 2013, Tietze 2014) han indicado que PRP ofrece mejores resultados en comparación con el AH o los corticosteroides, y el efecto se mantiene durante al menos 6 meses (2).…”

Section: Resultsunclassified

Un nuevo paradigma para el tratamiento de la osteoartritis de rodilla: el papel del ácido hialurónico, el plasma rico en plaquetas (PRP) y el ozono en la modulación de la inflamación: una revisión.

Fernández-Cuadros¹,

Moro²,

Florin³

et al. 2021

Rev. Soc. Esp. Dolor.

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“…Most studies covering the usage of ozone in knee pathologies include osteoarthritis [ 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 ] with up to 71.4% positive results [ 106 ]. The application of the ozone involved intra-articular and periarticular infiltrations [ 112 ] and injections [ 106 , 114 , 115 , 122 ].…”

Section: Ozone In the Pain Treatmentmentioning

confidence: 99%

Ozone in Chemotherapy-Induced Peripheral Neuropathy—Current State of Art, Possibilities, and Perspectives

Szklener

Rudzińska

Juchaniuk

et al. 2023

IJMS

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Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most detrimental toxicity to a patient’s quality of life. Pathophysiological mechanisms involved in CIPN pathogenesis are complex, multifactorial, and only partially examined. They are suspected to be associated with oxidative stress (OS), mitochondrial dysfunction, ROS-induced apoptosis, myelin sheath and DNA damage, and immunological and inflammatory processes. Unfortunately, medications commonly used for the management of other neuropathic pain syndromes, including gabapentinoids, opioids, and tricyclic antidepressants (such as desipramine and nortriptyline), do not bring satisfactory results in CIPN. The aim of this review is to evaluate the existing literature on the potential use of medical ozone as a treatment for CIPN. This paper would explore the potential therapeutic benefits of medical ozone. The review would evaluate the existing literature on the use of medical ozone in other contexts, as well as its potential application in treating CIPN. The review would also suggest possible research methods, such as randomized controlled trials, to evaluate the efficacy of medical ozone as a treatment for CIPN. Medical ozone has been used to disinfect and treat diseases for over 150 years. The effectiveness of ozone in treating infections, wounds, and a variety of diseases has been well documented. Ozone therapy is also documented to inhibit the growth of human cancer cells and has antioxidative and anti-inflammatory effects. Due to its ability to modulate oxidative stress, inflammation, and ischemia/hypoxia, ozone may have a potentially valuable effect on CIPN.

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Eficacia de las infiltraciones con ozono en el tratamiento de la osteoartritis de rodilla vs. otros tratamientos intervencionistas: revisión sistemática de ensayos clínicos

Cited by 9 publications

References 33 publications

Symptomatic (Pain and Inflammation) and Disease-Modifying Effect (Minimal Joint Space) of Intra-articular Ozone (O2-O3) in Osteoarthritis of the Knee: a Clinical Case

Symptomatic (Pain and Inflammation) and Disease-Modifying Effect (Minimal Joint Space) of Intra-articular Ozone (O2-O3) in Osteoarthritis of the Knee: a Clinical Case

Un nuevo paradigma para el tratamiento de la osteoartritis de rodilla: el papel del ácido hialurónico, el plasma rico en plaquetas (PRP) y el ozono en la modulación de la inflamación: una revisión.

Ozone in Chemotherapy-Induced Peripheral Neuropathy—Current State of Art, Possibilities, and Perspectives

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