Eficacia clínica del moxifloxacino en el tratamiento de abscesos odontogénicos submucosos

Limeres, Jacobo; García, E. Vázquez; Rial, M. Outumuro; Duran, Fatih; Tomás, Inmaculada; Dios, Pedro Diz

doi:10.1016/s1138-3593(06)73221-x

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Recently, we have found that all the streptococci isolated from a series of patients with iatrogenic bacteremia of oral origin showed a low MIC to MXF (47). Furthermore, we have demonstrated its efficacy in vivo for the treatment of submucous layer dental abscesses, confirming its penetration into tissue in the oral cavity (24).…”

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confidence: 57%

Comparative Efficacies of Amoxicillin, Clindamycin, and Moxifloxacin in Prevention of Bacteremia following Dental Extractions

Dios

Tomás

Limeres

et al. 2006

Antimicrob Agents Chemother

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We evaluated the efficacies of oral prophylactic treatment with amoxicillin (AMX), clindamycin (CLI), and moxifloxacin (MXF) in the prevention of bacteremia following dental extractions (BDE). Two hundred twentyone adults who required dental extractions under general anesthesia were randomly assigned to a control group, an AMX group, a CLI group, and an MXF group (the individuals in the drug treatment groups received 2 g, 600 mg, and 400 mg, respectively, 1 to 2 h before anesthesia induction). Venous blood samples were collected from each patient at the baseline and 30 s, 15 min, and 1 h after the dental extractions. The samples were inoculated into BACTEC Plus aerobic and anaerobic blood culture bottles and were processed in a BACTEC 9240 instrument. Subculture and the further identification of the isolated bacteria were performed by conventional microbiological techniques. The prevalences of BDE in the control group, AMX group, CLI group, and MXF group were 96, 46, 85, and 57%, respectively, at 30 s; 64, 11, 70, and 24%, respectively, at 15 min; and 20, 4, 22, and 7%, respectively, at 1 h. Streptococcus spp. were the most frequently identified bacteria in all groups (44 to 68%), with the lowest percentage being detected in the AMX group (44%). AMX and MXF prophylaxis showed high efficacies in reducing the prevalence and duration of BDE, but CLI prophylaxis was noneffective. As a consequence, MXF prophylaxis is a promising antibiotic alternative for the prevention of BDE when beta-lactams are not indicated.

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confidence: 57%

Comparative Efficacies of Amoxicillin, Clindamycin, and Moxifloxacin in Prevention of Bacteremia following Dental Extractions

Dios

Tomás

Limeres

et al. 2006

Antimicrob Agents Chemother

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“…[26] Furthermore, they have demonstrated its efficacy in-vivo for the treatment of submucous layer dental abscesses, confirming its penetration into tissue in the oral cavity. [27] In the following study efficacies of Amoxicillin and Moxifloxacin in prevention of bacteremia following tooth extraction were evaluated. The study group was made up of 30 patients, including 17 (57%) males and 13 (43%) females, with a average age of males 40.64 years (age range, 20 to 72 years) and of females were 35.53 (age ranges from 22-62).…”

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confidence: 99%

Comparative efficacies of Amoxicillin and Moxifloxacin in Prevention of Bacteremia following Dental Extraction

2013

IOSR-JDMS

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Eficacia clínica del moxifloxacino en el tratamiento de abscesos odontogénicos submucosos

Cited by 2 publications

References 22 publications

Comparative Efficacies of Amoxicillin, Clindamycin, and Moxifloxacin in Prevention of Bacteremia following Dental Extractions

Comparative Efficacies of Amoxicillin, Clindamycin, and Moxifloxacin in Prevention of Bacteremia following Dental Extractions

Comparative efficacies of Amoxicillin and Moxifloxacin in Prevention of Bacteremia following Dental Extraction

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