Efficiently Writing Bragg Grating in High-Birefringence Elliptical Microfiber for Label-Free Immunosensing with Temperature Compensation

Xiao, Peng; Xu, Zhiyuan; Hu, Deming; Liang, Lili; Sun, Li-Peng; Li, Jie; Ran, Yang; Guan, Bai‐Ou

doi:10.1007/s42765-021-00087-7

Cited by 28 publications

(4 citation statements)

References 56 publications

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“…Several approaches can be anticipated in order to further enhance the sensing capability of our biosensor, such as using localized surface plasmon resonance and tapered fiber to improve the sensitivity and using the antigen sandwich method to amplify the signal [51,52]. Furthermore, fiber Bragg grating can be added to the fiber ring cavity to realize multi-parameter detection and temperature compensation [53]. The photothermal effect of laser would be the next direction of our research [54,55].…”

Section: Discussionmentioning

confidence: 99%

Fiber Laser-Based Lasso-Shaped Biosensor for High Precision Detection of Cancer Biomarker-CEACAM5 in Serum

Song

Liu

et al. 2023

Biosensors

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Detection of trace tumor markers in blood/serum is essential for the early screening and prognosis of cancer diseases, which requires high sensitivity and specificity of the assays and biosensors. A variety of label-free optical fiber-based biosensors has been developed and yielded great opportunities for Point-of-Care Testing (POCT) of cancer biomarkers. The fiber biosensor, however, suffers from a compromise between the responsivity and stability of the sensing signal, which would deteriorate the sensing performance. In addition, the sophistication of sensor preparation hinders the reproduction and scale-up fabrication. To address these issues, in this study, a straightforward lasso-shaped fiber laser biosensor was proposed for the specific determination of carcinoembryonic antigen (CEA)-related cell adhesion molecules 5 (CEACAM5) protein in serum. Due to the ultra-narrow linewidth of the laser, a very small variation of lasing signal caused by biomolecular bonding can be clearly distinguished via high-resolution spectral analysis. The limit of detection (LOD) of the proposed biosensor could reach 9.6 ng/mL according to the buffer test. The sensing capability was further validated by a human serum-based cancer diagnosis trial, enabling great potential for clinical use. The high reproduction of fabrication allowed the mass production of the sensor and extended its utility to a broader biosensing field.

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Section: Discussionmentioning

confidence: 99%

Fiber Laser-Based Lasso-Shaped Biosensor for High Precision Detection of Cancer Biomarker-CEACAM5 in Serum

Song

Liu

et al. 2023

Biosensors

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“…In 2011, by integrating a 900-nm-diameter silica MNF into the microfluidic chip, Zhang et al demonstrated efficient sensing of bovine serum albumin using a 633-nm-wavelength probe light [244] , with a detection limit of 10 fg/mL and a probe light power down to 150 nW. Meanwhile, the selective detection of target analytes in biochemical samples can be achieved by immobilizing specific signal-responsive receptors [441][442][443] .…”

Section: As-fabricated Straight Mnfsmentioning

confidence: 99%

Optical microfiber or nanofiber: a miniature fiber-optic platform for nanophotonics

Zhang,

Fang,

Wang

et al. 2024

Photonics Insights

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“…A highly birefringent superfine fiber Bragg grating with temperature compensation was proposed by Xiao et al [ 143 ]. The effective recording of high reflectivity FBG is made possible by the significant energy overlap offered by MMF.…”

Section: Special Optical Fiber Structure-based Biosensing Applicationsmentioning

confidence: 99%

Novel Optical Fiber-Based Structures for Plasmonics Sensors

et al. 2022

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Optical fiber sensors based on surface plasma technology have many unique advantages in specific applications such as extreme environmental monitoring, physical parameter determination, and biomedical indicators testing. In recent decades, various kinds of fiber probes with special structures were developed according to special processing such as tapering, splicing, etching, fiber balls, grating etc. In this paper, the fabrication technology, characteristics, development status and application scenarios of different special optical fiber structures are briefly reviewed, including common processing equipment. Furthermore, many special novel optical fiber structures reported in recent years are summarized, which have been used in various kinds of plasmonic sensing work. Then, the fiber-plasmonic sensors for practical applications are also introduced and examined in detail. The main aim of this review is to provide guidance and inspiration for researchers to design and fabricate special optical fiber structures, thus facilitating their further research.

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Efficiently Writing Bragg Grating in High-Birefringence Elliptical Microfiber for Label-Free Immunosensing with Temperature Compensation

Cited by 28 publications

References 56 publications

Fiber Laser-Based Lasso-Shaped Biosensor for High Precision Detection of Cancer Biomarker-CEACAM5 in Serum

Fiber Laser-Based Lasso-Shaped Biosensor for High Precision Detection of Cancer Biomarker-CEACAM5 in Serum

Optical microfiber or nanofiber: a miniature fiber-optic platform for nanophotonics

Novel Optical Fiber-Based Structures for Plasmonics Sensors

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