Abstract:Optical fiber sensors based on surface plasma technology have many unique advantages in specific applications such as extreme environmental monitoring, physical parameter determination, and biomedical indicators testing. In recent decades, various kinds of fiber probes with special structures were developed according to special processing such as tapering, splicing, etching, fiber balls, grating etc. In this paper, the fabrication technology, characteristics, development status and application scenarios of dif… Show more
“…Therefore, part or all of the fiber cladding can be removed via chemical etching or by side-polishing methods, and nanoparticles or nanofilms can be deposited. Several optical fiber configurations such as unclad fibers, side-polished (or D-shaped) fibers, tapered, and U-shaped fibers have been demonstrated for sensing applications [106][107][108][109] . As a label-free method, these plasmonic biosensors detect biomolecular interactions with high sensitivity and low levels of detection (LOD).…”
Section: Plasmonic Optical Fibersmentioning
confidence: 99%
“…Several optical fiber configurations such as unclad fibers, side-polished (or Dshaped) fibers, tapered, and U-shaped fibers have been demonstrated for sensing applications. [106][107][108][109] As a label-free method, these plasmonic biosensors detect biomolecular interactions with high sensitivity and low levels of detection (LOD). Their broadband operation, along with their structural flexibility and nanomaterial functionalization, makes plasmonic optical fiber-based biosensors ideal for real-time and in situ biosensing and healthcare applications.…”
Section: Plasmonic Optical Fibersmentioning
confidence: 99%
“…Their broadband operation, along with their structural flexibility and nanomaterial functionalization, makes plasmonic optical fiber-based biosensors ideal for real-time and in situ biosensing and healthcare applications. 106,107,109…”
One of the most important processes in the fight against current and future pandemics is the rapid diagnosis and initiation of treatment of viruses in humans. In these times, the...
“…Therefore, part or all of the fiber cladding can be removed via chemical etching or by side-polishing methods, and nanoparticles or nanofilms can be deposited. Several optical fiber configurations such as unclad fibers, side-polished (or D-shaped) fibers, tapered, and U-shaped fibers have been demonstrated for sensing applications [106][107][108][109] . As a label-free method, these plasmonic biosensors detect biomolecular interactions with high sensitivity and low levels of detection (LOD).…”
Section: Plasmonic Optical Fibersmentioning
confidence: 99%
“…Several optical fiber configurations such as unclad fibers, side-polished (or Dshaped) fibers, tapered, and U-shaped fibers have been demonstrated for sensing applications. [106][107][108][109] As a label-free method, these plasmonic biosensors detect biomolecular interactions with high sensitivity and low levels of detection (LOD). Their broadband operation, along with their structural flexibility and nanomaterial functionalization, makes plasmonic optical fiber-based biosensors ideal for real-time and in situ biosensing and healthcare applications.…”
Section: Plasmonic Optical Fibersmentioning
confidence: 99%
“…Their broadband operation, along with their structural flexibility and nanomaterial functionalization, makes plasmonic optical fiber-based biosensors ideal for real-time and in situ biosensing and healthcare applications. 106,107,109…”
One of the most important processes in the fight against current and future pandemics is the rapid diagnosis and initiation of treatment of viruses in humans. In these times, the...
“… 36 , 37 For instance, combining LSPR of different NPs to optical fibers has demonstrated the advantages of miniaturization and portability in the detection of both small and large biomolecules. 38 , 39 Viral biosensors can be categorized based on their viral targets into antigen-, cell-, immune-, and DNA-based sensors. 40 − 44 The predictable and specific hybridization of the complementary bases that are based on nucleic acid hybridization of DNA-viral targets have demonstrated preserved reactivity, stability, accessibility, and low cost.…”
Section: Introductionmentioning
confidence: 99%
“…The need for newer methodologies for diagnosis of rapid turnaround time, simple operation, and direct readout continues to rise. Plasmonic-based sensors have displayed high detection speed, sensitivity, and portability and thus promising for disease diagnosis. , For instance, combining LSPR of different NPs to optical fibers has demonstrated the advantages of miniaturization and portability in the detection of both small and large biomolecules. , Viral biosensors can be categorized based on their viral targets into antigen-, cell-, immune-, and DNA-based sensors. − The predictable and specific hybridization of the complementary bases that are based on nucleic acid hybridization of DNA-viral targets have demonstrated preserved reactivity, stability, accessibility, and low cost.…”
A surface plasmon resonance (SPR)-enhanced optical signal
using
a nanoslit array and acridine orange (AO) dye system at a flexible
poly(dimethylsiloxane) (PDMS) substrate was achieved in this work
and demonstrated a simple sensing scheme to directly detect SARS-CoV-2
nucleic acid via DNA hybridization. A simple nanoimprinting pattern
transfer technique was introduced to form uniform reproducible nanoslit
arrays where the dimensions of the slit array were controlled by the
thickness of the gold film. The plasmon–exciton coupling effect
on the optical enhancement of different dye molecules, i.e., AO, propidium
iodide (PI), or dihydroethidium (DHE) attached to the nanoslit surfaces,
was examined thoroughly by measuring the surface reflection and fluorescence
imaging. The results indicate that the best overlap of the plasmon
resonance wavelength to the excitation spectrum of AO presented the
largest optical enhancement (∼57×) compared to the signal
at flat gold surfaces. Based on this finding, a sensitive assay for
detecting DNA hybridization was generated using the interaction of
the selected SARS-CoV-2 ssDNA and dsDNA with AO to trigger the metachromatic
behavior of the dye at the nanoarray surfaces. We found strong optical
signal amplification on the formation of acridine-ssDNA complexes
and a quenched signal upon hybridization to the complementary target
DNA (ct-DNA) along with a blue shift in the fluorescence of AO-dsDNAs.
A quantitative evaluation of the ct-DNA concentration in a range of
100–0.08 nM using both the reflection and emission imaging
signals demonstrated two linear regimes with a lowest detection limit
of 0.21 nM. The sensing method showed high sensitivity and distinguished
signals from 1-, 2-, and 3-base mismatched DNA targets, as well as
high stability and reusability. This approach toward enhancing optical
signal for DNA sensing offers promise in a general, rapid, and direct
vision detection method for nucleic acid analytes.
Due to low losses, optical fibers are excellent optical waveguides, but manipulating the wavefront below the diffraction limit while keeping fabrication costs down is a significant challenge. Top‐down lithographic methods can create arbitrary nanostructures on the fiber end face to manipulate the wavefront. Still, this method requires a flat fiber end face, which can only be made using elaborate preparation processes. We present a facile coating method in which we transfer a hexagonally packed monolayer of gold nanoparticles onto an untreated fiber end face. Using a poly(N‐isopropylacrylamide) particle coating, we could transfer the free‐floating monolayer from a water‐air interface to the fiber end face. Our self‐assembly method enables plasmonic gratings on rough surfaces and objects with large aspect ratios, which have been challenging for existing nanofabrication methods. Using electromagnetic simulation, we demonstrate the performance and utility of the concept as a refractive index sensor in which we consider different lattice constants. Our simulations cover possible analyses by calculating the structure under air, water, and polymer environments. Thus, we study the potential applications of low‐cost fiber‐based sensors with low optical losses.
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