Efficient wound odor removal by β‐cyclodextrin functionalized poly (ε‐caprolactone) nanofibers

Abstract

Polymer-cyclodextrin (CD) composite nanofibers, by virtue of the hollow cavities and abundant hydroxyl groups present in CDs, have tremendous potential in a variety of biomedical applications. However, in most cases, especially in aliphatic polyesters, polymer chains thread readily into CD cavities, therefore its potential has not yet been fully realized. Herein, we report the formation of poly(e-caprolactone) (PCL)/b-CD functional nanofibers by electrospinning their mixture from chloroform/N,N-dimethylformamide (60 : 40). The fiber diameters of the neat PCL and b-CD functionalized fibers were measured from the images obtained from a scanning electron microscope and were found to be about 500 nm. The efficiency of wound odor absorbance by these composite fibers was studied using a simulated wound odor solution, consisting of butyric and propionic acids in ethanol. Immersion tests indicated that even under less than ideal test conditions, the nanofibers containing b-CDs were very efficient in masking the odor. The odor masking capability of the b-CD functionalized PCL nanofibers were further confirmed by thermogravimetric analyses and GC observations, with the former method showing unique degradation patterns. The PCL/b-CD nanocomposites, by virtue of having their b-CD cavities free and unthreaded by PCL, could potentially be an ideal substrate for removing wound odors through formation of inclusion compounds with odorants, while providing an ideal environment for the wound to heal. These results suggest tailoring polymer-CD nanostructures for specific applications in wound odor absorbance, surface grafting of chemical moieties, and vehicles for drug delivery, as examples.

Polyrotaxane-based supramolecular theranostics

“…XRD diffractograms of β -CD-NH 2 indicated a series of peaks ranging from 5° to 40°, confirming the macrocyclic structure 17 . PDI-PCL- b -PEG-Mal, a semicrystalline material with orthorhombic crystal structure, exhibited two distinct diffraction peaks at 22° and 24°, related to (110) and (200) lattice structures, respectively 18 . For PDI-PCL- b -PEG-RGD⊃ β -CD-NH 2 , the most intense diffraction peak appeared at 19.8°, and the characteristic peaks of PCL broadened and the β -CD-NH 2 peaks diminished upon the formation of polyrotaxane.…”

Fabrication and characterization of electrospun poly(e-caprolactone) fibrous membrane with antibacterial functionality

“…The neat PCL nanofibres were found to be stable up to 380°C, whereas complete degradation took place at about 410°C [39,40]. Therefore, addition of silver chloride to fibre matrix was anticipated to lower thermal stability due to a two-stage thermal degradation process [41].…”

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

“…Due to their versatility and in-expensive setup costs, it is fast emerging as a technique to prepare fibers with sub-micron diameters [61, 62]. In principle, an electrospinning apparatus consists of (1) a high precision pump to deliver solution, (2) a high voltage generating source, and (3) a collector to collect fibers in the form of a non-woven mat.…”