Polyrotaxane-based supramolecular theranostics

Yu, Guocan; Yáng, Zhèn; Fu, Xiao; Yung, Bryant C.; Yang, Jie; Mao, Zhengwei; Shao, Li; Hua, Bin; Liu, Yijing; Zhang, Fuwu; Fan, Quli; Wang, Sheng; Jacobson, Orit; Jin, Albert J.; Gao, Changyou; Tang, Xiaoying; Huang, Feihe; Chen, Xiaoyuan

doi:10.1038/s41467-018-03119-w

Cited by 206 publications

(132 citation statements)

References 35 publications

Supporting

Mentioning

128

Contrasting

Order By: Relevance

“…Organic molecular PA contrast agents, including porphyrin, melanin, cyanine‐based dyes, and perylene‐diimide (PDI), have been widely applied in PA imaging due to their excellent biodegradability and biocompatibility. In 2011, Zheng and co‐workers developed porphysomes by combining porphyrin with phospholipids and integrating porphyrin–phospholipids into nanovesicles via a self‐assembly approach .…”

Section: Organic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

Self Cite

View full text Add to dashboard Cite

Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

show abstract

Section: Organic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Folate-terminated polyrotaxanes were developed by modifying PEG chains and target mitochondrium [18]. Polyrotaxane-based theranostics were also fabricated with excellent anti-tumor performance [19]. Cationic cyclodextrin polyrotaxanes can be also used for the cellular delivery of polynucleotides [20] and genes [21].…”

Section: Cyclodextrin Associates Polypseudorotaxanes and Polyrotaxanesmentioning

confidence: 99%

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

et al. 2019

View full text Add to dashboard Cite

Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity.

show abstract

“…19 The synthesis, characterization and mechanism of threading of PRs and PPRs based on CDs and different polymers, have been extensively reviewed in the literature, 2,3,20 as well as their potential applications in biomedicine, particularly in drug delivery, or biomaterials, such as hydrogels and scaffolds in tissue engineering. 9,10,[21][22][23] The first PPR based on CDs was reported by Harada in 1990, 24 and obtained from the complexation of PEG and α-CD in water, with a composition of 2 ethylene oxide (EO) units per CD. Harada also established that the binding is very selective, depending on the type of CD and monomer: 1,24,25 α-CD only forms stable inclusion complexes with PEG, while the threading does not occur with polypropylene glycol (PPG); instead, β-and γ-CD form PPRs with PPG but not with PEG.…”

Section: Introductionmentioning

confidence: 99%

Pseudo-Polyrotaxanes of Cyclodextrins with Direct and Reverse X-Shaped Block Copolymers: A Kinetic and Structural Study

et al. 2019

View full text Add to dashboard Cite

Pseudo-polyrotaxanes (PPRs) are supramolecular host-guest complexes constituted by the reversible threading of a macrocycle along a polymer chain, which offers potential applications in nanotechnology, drug delivery and biomaterials. We report the threading of cyclodextrins (CDs), cyclic oligosaccharides, onto X-shaped PEO-PPO block-copolymers, with two opposite presentation of their hydrophobic and hydrophilic blocks: Tetronic 904 (T904), and its reverse counterpart, Tetronic T90R4. We assess the effect of relative block position on the polymeric surfactants and cavity size of CD have on the composition, morphology, thermodynamics and kinetics of PPRs by using a combination of X-ray diffraction, Scanning Electron Microscopy (SEM), NMR, UV-Vis spectroscopy and Time-Resolved Small-Angle Neutron Scattering (TR-SANS). Solid PPRs with lamellar microstructure and crystalline channel-like structures are obtained with native CDs and both Tetronics above a threshold concentration of the macrocycle, which varies with the type of CD and surfactant. While γ-CD can form PPRs with both Tetronics, α-CD only form a PPR with T90R4 at high concentrations. The results can be explained in terms of the preferential complexation of α-CD with EO and γ-CD with PO monomers, which also has a direct impact on the kinetics of PPR formation. Thermodynamic parameters of the reaction were obtained from the analysis of the stoichiometries and threading times as a function of temperature by using a model based on the Eyring equation. Negative enthalpies and positive entropies are obtained in all cases, and reactions are thermodynamically most favorable in the case of α-CD with T904 and γ-CD with T90R4. TR-SANS experiments reveal an increase in the radius of gyration of the unimers over time, consistent with CDthreading and expansion of the PPR. Above the CMT, α-CD threads the unimers to form the PPR, with no effect on the structure of T904 micelles, whose volume fraction decreases due to the shift of micellization equilibrium.

show abstract

Polyrotaxane-based supramolecular theranostics

Cited by 206 publications

References 35 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

Pseudo-Polyrotaxanes of Cyclodextrins with Direct and Reverse X-Shaped Block Copolymers: A Kinetic and Structural Study

Contact Info

Product

Resources

About