Efficient Synthesis of Primary Selenocarboxylic Amides by Reaction of Nitriles with Phosphorous(V) Selenide

Abstract

The reaction of nitriles with P 2 Se 5 in the presence of EtOH/H 2 O afforded a variety of primary selenocarboxylic amides.

Synthesis of 2‐Unsubstituted 1,3‐Selenazoles by Cyclization of Selenoformamide with α‐Bromocarbonyl Compounds

“…Selenoformamide ( 1 ) was prepared, using our previously reported procedure, by reaction of neat formamide with (freshly prepared) phosphorous(V) selenide (P 2 Se 5 ). We have observed during our present study that the reaction is considerably accelerated by the use of ultrasound irradiation.…”

Synthesis and Applications of Chalcogenoamide: Thio-, Seleno- and Telluroamides

“…The primary selenoamides are prepared by reaction of nitriles with appropriate selenating reagents such as phosphorus (V) selenide (P 2 Se 5 ), hydrogen selenide (H 2 Se), Al 2 Se 3 , NaSeH, tris(trimethylsilyl)monoselenophosphate or potassium selenobenzoate [86][87][88][89][90] (Scheme 32). R As other preparation methods of secondary and tertiary selenoamides 57, a combination of lithium alkyneselenolates and amines, one of aromatic diselenoic acid Se-methyl esters and amines, or dihalomethane with elemental selenium, NaH and amines have been established [96][97][98][99][100][101][102][103][104] (Scheme 34).…”

Synthesis of Various Derivatives of [1,3]Selenazolo[4,5‐d]pyrimidine and Exploitation of These Heterocyclic Systems as Antibacterial, Antifungal, and Anticancer Agents

“…They have been prepared from the treatment of selenourea/primary selenoamides and aromatic/aliphatic α-halo carbonyls. [65][66][67][68] As an example, the synthesis through the condensation of selenourea with phenacyl bromides in eco-friendly conditions was described. [69,70] Some other miscellaneous procedures for the synthesis of mentioned amino-selenazoles are solid-state synthesis employing a Lewis acid catalyst [71] and aqueous phase one-pot synthesis under supramolecular catalysis.…”