“…Pérez et al described the preparation of 9-aryl-6-chloropurines following alternative synthetic approaches. 54 One of these procedures consisted of a two-step MW-assisted reaction (mono-mode Biotage Initiator 2.0). The aniline derivatives were rst bound to dichloroaminopyrimidines and then cyclisation to 9-arylpurines was carried out under MW in the presence of trimethylorthoformate in acetic anhydride (120 C, 1 h) (Scheme 26).…”
“…Pérez et al described the preparation of 9-aryl-6-chloropurines following alternative synthetic approaches. 54 One of these procedures consisted of a two-step MW-assisted reaction (mono-mode Biotage Initiator 2.0). The aniline derivatives were rst bound to dichloroaminopyrimidines and then cyclisation to 9-arylpurines was carried out under MW in the presence of trimethylorthoformate in acetic anhydride (120 C, 1 h) (Scheme 26).…”
“…Despite the impact of CVB3 infections on human health, there is no drug approved for the treatment of these infections. Currently, a number of compounds have been described as selective inhibitors of CVB3 replication in vitro [11]. Aguado et al recently synthesized a number of 9-arylpurines with significant activity against CVB3.…”
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