Efficient synthesis and anti-enteroviral activity of 9-arylpurines

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

“…Pérez et al described the preparation of 9-aryl-6-chloropurines following alternative synthetic approaches. 54 One of these procedures consisted of a two-step MW-assisted reaction (mono-mode Biotage Initiator 2.0). The aniline derivatives were rst bound to dichloroaminopyrimidines and then cyclisation to 9-arylpurines was carried out under MW in the presence of trimethylorthoformate in acetic anhydride (120 C, 1 h) (Scheme 26).…”

Antiviral activity of 1-(1-arylimidazolidine-2-ylidene)-3-(4-chlorobenzyl)urea derivatives

“…Despite the impact of CVB3 infections on human health, there is no drug approved for the treatment of these infections. Currently, a number of compounds have been described as selective inhibitors of CVB3 replication in vitro [11]. Aguado et al recently synthesized a number of 9-arylpurines with significant activity against CVB3.…”

Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

“…Antienteroviral [67] Oxazole-, thiazole-, and imidazole-based tricyclic compounds (60) Na 2 CO 3 or t BuOK, DMF, (MWI, 200-220 °C, 1 h)…”