Antiviral activity of 1-(1-arylimidazolidine-2-ylidene)-3-(4-chlorobenzyl)urea derivatives

Abstract

activity of 1-(1-arylimidazolidine-2-ylidene)-3-(4chlorobenzyl)urea derivatives. J Pre-Clin Clin Res. 2013; 7(2): 104-106.

Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments

“…If the difference in titers was 1.0–2.0 lg, then the substance was considered to have moderate or pronounced antiviral activity [ 32 ]. The infectious titer of viruses was determined by the method of Reed and Muench [ 33 ].…”

A New Class of Linezolid‐Based Molecules as Potential Antimicrobial and Antitubercular Agents: A Rational Approach

“…In this study, we have produced a small library of 19 linezolidbased molecules (6 a-d, 8 a-d and 10 a-k) quantitatively in a simple and convenient manner employing an attractive starting material 1,2-difluoro-4-nitrobenzene (1). All the synthesized derivatives were well-characterized with spectroscopic method such as FT-IR, mass and NMR ( 1 H, 13 C), moreover the structures of some representative compounds were substantiated by 19 F and 2D NMR (HMBC, HSQC, COSY and NOESY). The crystal structures of two compounds (6 d and 8 b) were also solved by single X-ray diffractometer.…”

“…Experimental procedures for preparation of the title compounds can be found in supporting information. Furthermore, the figure of NMR ( 1 H, 13 C, 19 F and 2D), FT-IR, and mass spectral analysis of the prepared compounds are also provided. Deposition Number(s) 2049298 (for 6d), 1986001 (for 8b), contain(s) the supplementary crystallographic data for this paper.…”

“…[14] The divalent sulphur is characterized by its ability to interact with electron-poor as well as with electron-rich functional groups, which improves the binding ability of the molecule to receptors more efficiently. Drugs having urea/thiourea functionality are known to display anticonvulsant, [15] antimicrobial, [16] anti-trypanosomal, [17] antidepressant, [18] antiviral, [19] anti-acetylcholinesterase, [20] antiproliferative [21] and anti-inflammatory. [22] Furthermore, sulfone containing bioactive molecules have been reported to display several therapeutic activities, including antimicrobial, antifungal, antimalarial, anti-cancer, anti-HIV, anti-proliferative, enzyme inhibitors and anti-inflammatory activity.…”

Novel Trifluoromethylcoumarinyl Urea Derivatives: Synthesis, Characterization, Fluorescence, and Bioactivity

“…Ureas are very important compounds in organic chemistry because of their extensive applications in medicine and agriculture. The substituted ureas exhibit diversified medicinal activities such as antimicrobial [ 1 ], antiviral [ 2 ], anti-HIV [ 3 ], anti-AIDS [ 4 ], anti-malaria [ 5 ], anti-proliferative [ 6 ], antitumor [ 7 ], anticancer [ 8 ], anti-inflammatory [ 9 ], anti-ulcerogenic [ 10 ], anticonvulsant [ 11 ], anti-nociceptive [ 12 ], antihypertensive [ 9 ], antidepressant [ 13 ], complement inhibition [ 14 ], HDL-elevating [ 15 ], and inhibition of nitric oxide [ 16 ]. Urea compounds also possess a broad spectrum of pesticidal activities, such as benzoylurea type insecticides (Diflubenzuron, Chlorbenzuron, etc.)…”