Efficient strategy for the selective determination of dopamine in human urine by molecularly imprinted solid‐phase extraction

Luliński, Piotr; Bamburowicz-Klimkowska, Magdalena; Dana, Mariusz; Szutowski, Mirosław; Maciejewska, Dorota

doi:10.1002/jssc.201501159

Cited by 25 publications

(13 citation statements)

References 35 publications

(42 reference statements)

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“…Nevertheless, the best eluent should be characterized by the highest desorption of analyte in the lowest volume of eluent. In our previous studies, we have showed the importance of scrutinous selection of efficient eluent for each individual imprinted sorbent . Here, for that purpose, 0.08 aq.…”

Section: Resultsmentioning

confidence: 99%

Design of selective molecularly imprinted sorbent for the optimized solid‐phase extraction of S‐pramipexole from the model multicomponent sample of human urine

Woźnica

Luliński

2019

J of Separation Science

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The objective of this article was to design the selective molecularly imprinted sorbent dedicated to the solid‐phase extraction of S‐pramipexole from the complex matrix such as human urine. For that purpose, S‐2,6‐diamino‐4,5,6,7‐tetrahydrobenzothiazole was used as the template acting as the structural analog of S‐pramipexole and five various monomers were employed in the presence of ethylene glycol dimethacrylate to produce molecularly imprinted polymers. The binding capabilities of resulted polymers revealed that the highest imprinting effect was noted for polymer prepared from the itaconic acid. The comprehensive analysis of morphology and the characterization of binding sites showed not only negligible differences in the extension of surfaces of imprinted and nonimprinted polymers but also higher heterogeneity of binding sites in the imprinted material. Comprehensive optimization of the molecularly imprinted solid‐phase extraction allowed to select the most appropriate solvents for loading, washing, and elution steps. Subsequent optimization of mass of sorbent and volumes of solvents allowed to achieve satisfactory total recoveries of S‐pramipexole from the model multicomponent real sample of human urine that equals to 91.8 ± 3.2% for imprinted sorbent with comparison to only 37.1 ± 1.1% for Oasis MCX.

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Section: Resultsmentioning

confidence: 99%

Design of selective molecularly imprinted sorbent for the optimized solid‐phase extraction of S‐pramipexole from the model multicomponent sample of human urine

Woźnica

Luliński

2019

J of Separation Science

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“…As a new separation technique, molecular imprinting can make the active components of natural products highly concentrated with few impurities and effectively improve the purity of products. Molecularly imprinted polymers (MIPs) have shown the important applications for the purification and preconcentration of biomolecules from complex human fluids such as urine or postmortem blood (Lulinski et al, 2015(Lulinski et al, , 2016.…”

Section: Introductionmentioning

confidence: 99%

Selective Adsorption and Purification of the Acteoside in Cistanche tubulosa by Molecularly Imprinted Polymers

2020

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Acteoside (ACT) is the main component of phenylethanoid glycosides in Cistanche tubulosa, and it is extremely desirable for obtaining high purification of ACT by molecularly imprinted polymers (MIPs) from their extracts. In this study, MIPs were designed and synthetized to adsorb selectively the ACT in C. tubulosa. The effects of different functional monomers, cross-linkers, and solvents of MIPs were investigated. MIPs were studied in terms of static adsorption experiments, dynamic adsorption experiments, and selectivity experiments. The optimal functional monomer, cross-linking agent, and solvent are 4-vinylpyridine, ethylene glycol dimethylacrylate, and the mixed solvent (acetonitrile and N,N-dimethylformamide, 1:1.5, v/v), respectively. Under the optimal conditions, the synthesized MIP1 has a high adsorption performance for ACT. The adsorption capacity of MIP1 to ACT reached 112.60 mg/g, and the separation factor of ACT/echinacoside was 4.68. Because the molecularly imprinted cavities of MIP1 resulted from template molecules of ACT, it enables MIP1 to recognize selectively ACT. Moreover, the N-H groups on MIP1 can form hydrogen bonds with the hydroxyl groups on the ACT; this improves the separation factor of MIP1. The dynamic adsorption of ACT accorded with the quasi-second-order kinetics; it indicated that the adsorption process of MIP1 is the process of chemical adsorption to ACT. MIPs can be applied as a potential adsorption material to purify the active ingredients of herbal medicines.

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“…Recently, the authors of some excellent review papers discussed different formats of MIPs . Also, numerous papers revealed the application of MIPs for the determination of bioanalytes such as bioamines . The MIPs were also successfully applied in fabrication of sensors and drug delivery devices .…”

Section: Introductionmentioning

confidence: 99%

Development of a validated strategy for the determination of tryptamine in human cerebrospinal fluid in the presence of competitors using molecularly imprinted polymers

Luliński

Bamburowicz-Klimkowska

Dana

et al. 2017

J of Separation Science

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This study presents a validated strategy for the determination of tryptamine in the presence of its competitors, which involves the molecularly imprinted solid-phase extraction combined with high-performance liquid chromatography coupled with fluorimetric detection. Tryptamine-imprinted microscale sorbent was produced from 4-vinylbenzoic acid and ethylene glycol dimethacrylate in methanol by precipitation polymerization, and its imprinting factor was equal to 15.4 in static experiments or 18.6 in dynamic binding experiments. The method for tryptamine determination in the presence of serotonin and l-tryptophan was validated using a complex matrix of bovine serum albumin yielding the recoveries of tryptamine that ranged between 98.7 and 107.0%. Very low limits of detection and limits of quantification for tryptamine (19.9 and 60.3 nmol/L, respectively) allow the quantification of tryptamine in human cerebrospinal fluid in the presence of tryptophan and serotonin.

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Efficient strategy for the selective determination of dopamine in human urine by molecularly imprinted solid‐phase extraction

Cited by 25 publications

References 35 publications

Design of selective molecularly imprinted sorbent for the optimized solid‐phase extraction of S‐pramipexole from the model multicomponent sample of human urine

Design of selective molecularly imprinted sorbent for the optimized solid‐phase extraction of S‐pramipexole from the model multicomponent sample of human urine

Selective Adsorption and Purification of the Acteoside in Cistanche tubulosa by Molecularly Imprinted Polymers

Development of a validated strategy for the determination of tryptamine in human cerebrospinal fluid in the presence of competitors using molecularly imprinted polymers

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