Efficient reduction and pH co-triggered DOX-loaded magnetic nanogel carrier using disulfide crosslinking

Huang, Juan; Xue, Yanan; Cai, Ning; Zhang, Han; Wen, Kaikai; Luo, Xiaogang; Long, Sihui; Yu, Faquan

doi:10.1016/j.msec.2014.10.003

Cited by 47 publications

(40 citation statements)

References 40 publications

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“…To evaluate the redox-responsiveness of the Dex-SS-PAA NGs, the reducing agent L-glutathione reduced GSH (10 mM) was added into an aqueous Dex-SS-PAA NG solution to simulate the tumor microenvironment1639. The molecular weight of the system was calculated via the Zimm plot method based on SLS measurements40.…”

Section: Resultsmentioning

confidence: 99%

Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems

Wang

Dai

Zhou

et al. 2017

Sci Rep

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In order to overcome the key challenge in improving both fabrication efficiency and their drug delivery capability of anti-cancer drug delivery systems (ACDDS), here polyacrylic acid (PAA) grafted dextran (Dex) nanohydrogels (NGs) with covalent crosslinked structure bearing redox sensitive disulfide crosslinking junctions (Dex-SS-PAA) were synthesized efficiently through a one-step self-assembly assisted methodology (SAA). The Dex-SS-PAA were subsequently conjugated with doxorubicin through an acid-labile hydrazone bond (Dex-SS-PAA-DOX). The in vitro drug release behavior, anti-cancer effects in vivo, and biosafety of the as-prepared acid- and redox-dual responsive biodegradable NGs were systematically investigated. The results revealed that the Dex-SS-PAA-DOX exhibited pH- and redox-controlled drug release, greatly reduced the toxicity of free DOX, while exhibiting a strong ability to inhibit the growth of MDA-MB-231 tumors. Our study demonstrated that the Dex-SS-PAA-DOX NGs are very promising candidates as ACDDS for anti-cancer therapeutics.

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Section: Resultsmentioning

confidence: 99%

Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems

Wang

Dai

Zhou

et al. 2017

Sci Rep

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“…Therefore, the tumor environment is more acidic than that of normal tissues (pH = 7.4) (J. Huang et al, 2015;M. Huang et al, 2016;Liao et al, 2018;Tannock & Rotin, 1989;.…”

Section: Ph-responsive Nanomedicinementioning

confidence: 99%

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Liao

Jia

et al. 2019

WIREs Nanomed Nanobiotechnol

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Cancer therapy is unsatisfactory as it typically has serious side effects, because normal cells in healthy organs are destroyed along with the tumor. Thus, researchers have tried to develop effective therapies with minimal side effects. One such method is to use nanotechnology to carry the drugs or therapeutic agents to the tumor region by secure encapsulation without leakage. Once the nanomedicine enters the target tumor site, it can release therapeutic agents in an effective manner. Accordingly, various nanomedicines have been developed to enhance the efficiency of cancer therapy and minimize the systematic toxicity. Here, we provide an overview and discuss the different types of responsive nanomedicines including physically, chemically, biologically, dual, and multi‐responsive nanomedicines, for the in situ release of cargos in recent years. We propose critical considerations that must be considered for the design of excellent stimuli‐nanomedicine. Furthermore, the possible directions for the development of successful stimuli‐responsive (smart) nanomedicine are highlighted. With the development of responsive nanomedicines, precise and personalized nanomedicine will be realized with great promise in the future. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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“…Likely, the rate of the removal of particles incurred by magnetic migration in Figure 2b can be expressed in terms of Equation 6:…”

Section: Mathematical Simulationmentioning

confidence: 99%

“…[1] The ability to physically direct and focus the medicine to specific sites in the body would allow better treatment of not only cancer but other diseases. [2,3] Therefore, therapeutic magnetic elements have been fabricated by the attachment of chemotherapy [4][5][6] or gene therapy [7] to ferromagnetic particles. [2,3] Therefore, therapeutic magnetic elements have been fabricated by the attachment of chemotherapy [4][5][6] or gene therapy [7] to ferromagnetic particles.…”

Section: Introductionmentioning

confidence: 99%

A Pseudo‐Model Strategy Combining Experiment and Model to Investigate the Targeting Efficiency of Injected Magnetic Nanoparticles as Therapeutics Carriers

Liu

Xue

et al. 2015

Adv Eng Mater

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Magnetic drug targeting (MDT) with the attachment of therapeutics on magnetizable particles to position them to target locations for the enhancement of targeting efficiency (TE) would allow better treatment of not only cancer but other diseases. However, the TE is low usually. The prediction of TE is necessary but difficult in whether theoretical or experimental aspect. A pseudo-model strategy dependent on both the experiment and model was developed to this end. Two processes of blood circulation clearance and targeting magnetic migration were abstracted to depict the fate of in vivo injected magnetic particles. The pseudo-model is to calculate TE in terms of two variables, or the half lives representing the respective characteristic time for the two processes, which can be conveniently determined experimentally. Two magnetic particles of different mobility were prepared for the in vitro assessment of the model. The experimental results verified the reliability of the model. An optimal targeting time was proposed to guide the targeting process. The model also provides a clue that the TE cannot be high. The strategy can determine TE readily by broad choice of these parameters. ADVANCED ENGINEERING MATERIALS 2015, 17, No. 10 Y. Liu et al./A Pseudo-Model Strategy Combining Experiment and Model… ADVANCED ENGINEERING MATERIALS 2015, 17, No. 10

show abstract

Efficient reduction and pH co-triggered DOX-loaded magnetic nanogel carrier using disulfide crosslinking

Cited by 47 publications

References 40 publications

Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems

Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

A Pseudo‐Model Strategy Combining Experiment and Model to Investigate the Targeting Efficiency of Injected Magnetic Nanoparticles as Therapeutics Carriers

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