Efficient One-Pot Synthesis of 1,4-Dihydropyridines Catalyzed by Magnetic MnFe2O4 Nanoparticles

Abstract

The efficient one-pot synthesis of some 1,4-dihydropyridines is described by a condensation reaction of some aldehyde derivatives, ethyl acetoacetate and ammonium acetate in the presence of superparamagnetic manganese ferrite nanoparticles at 80 °C. The advantages of this protocol include selectivity, high purity of the products, excellent yields, short reaction times, ease of processing, and environmentally friendly conditions for the synthesis of 1,4-dihydropyridines. In addition, the catalyst can be recovered and reused in multiple runs without significantly reducing the product yield.

1,4-Dihydropyridine: synthetic advances, medicinal and insecticidal properties

“…Furthermore, the product yield can be slightly decreased by recovering and reusing the catalyst across several runs (Scheme 11). 28 For the rst time, Patra et al (2022) took advantage of the activated pyridinium salts with, -diuorinated gem-diols 11a, creating a highly regioselective and simple synthesis of 1,4-DHPs ornamented with a high-value gem-diuoro methylene motif 11 in high yields. The protocol has a wide substrate scope, is scalable, and is compatible with many different functional groups.…”

“…Furthermore, the product yield can be slightly decreased by recovering and reusing the catalyst across several runs ( Scheme 11 ). 28 …”

Preparation and Characterization of NiCoFe2O4 Nanoparticles as an Effective Catalyst for the Synthesis of Trisubstituted Imidazole Derivatives Under Solvent-free Conditions

“…40 Recently, some of the nanoparticles have been used as catalysts for the synthesis of heterocyclic compounds. [41][42][43][44][45] Continuing our work on catalytic reactions, [46][47][48][49] we would like to report here on the preparation of NiCoFe 2 O 4 NPs as nanocatalysts for the four-component synthesis of tri-substituted imidazoles from benzil and aromatic aldehydes with ammonium acetate under solvent-free conditions.…”