Efficient multiresidue determination method for 168 pharmaceuticals and metabolites: Optimization and application to raw wastewater, wastewater effluent, and surface water in Beijing, China

Zhang, Yizhe; Duan, Lei; Wang, Bin; Liu, Cristina Su; Jia, Yichen; Zhai, Nannan; Blaney, Lee; Yu, Gang

doi:10.1016/j.envpol.2020.114113

Cited by 60 publications

(31 citation statements)

References 50 publications

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“…Usually, they are found at higher concentrations than those reported in urban wastewaters, reaching a few hundreds of μg/L ( Verlicchi, 2018 ). According to Zhang et al (2020) the overuse and abuse of antibiotics have promoted the development and spread of antibiotic resistance genes, originating from antibiotic resistant bacteria, which pose potential risks to human health and eco-environment. In the present study, detection of four SAs and TMP was investigated.…”

Section: Resultsmentioning

confidence: 99%

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Kosma

Kapsi

Konstas

et al. 2020

Environmental Research

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Nowadays the occurrence and associated risks of Pharmaceutical Active Compounds (PhACs) in the aquatic environment comprises a major issue. In the present study, a comprehensive survey on contamination profiles, occurrence, removals, temporal variation and ecological risk of multiclass multiresidue PhACs, such as antibiotics, non-steroidal anti-inflammatories, lipid regulators and phsychiatrics, (including past and newly monitored PhACs as well as some of their metabolites) was performed in wastewaters from the WWTP of Ioannina University hospital along one year period on a monthly sampling basis. WWTP influent and effluent samples were analyzed for physicochemical quality parameters and PhACs concentration levels using Ultra High Performance Liquid Chromatography-Orbitrap-Mass Spectrometry (UHPLC-Orbitrap-MS), after Solid Phase Extraction (SPE) through Oasis HLB cartridges. Influent concentrations ranged between < LOQ (Limit of Quantification) for diclofenac and tolfenamic acid and 48586 ng/L for caffeine, while effluent concentrations between < LOQ for tolfenamic acid and simvastatin and 3361 ng/L for caffeine. Removal efficiencies ranged between −132.6% for venlafaxine and 100% for caffeine. Environmental risk assessment by means of Risk Quotient (RQ) for maximum and minimum concentration levels as well as optimized by the frequency of exceeding toxicity threshold values, RQ f , was applied revealing that up to 12 PhACs posed acute toxicity (clofibric acid, fenofibrate, sulfadiazine, sulfamethoxazole, trimethoprim, amitryptiline, fluoxetine, fluvoxamine, norfluoxetine, sertraline, venlafaxine, caffeine) while up to 4 compounds exerted long-term toxicity (sulfamethoxazole, fluoxetine, sertraline, caffeine) at least for one of the studied organisms. Furthermore, mixture RQ MEC/PNEC and RQ STU effect of multiple compounds showed high potential risks of the target groups in some cases, although some contaminants were not included due to lack of available data. Results can be used to prioritization of PhACs and their metabolites for surveillance in receiving water bodies as well as development of knowledge on toxicity and mechanism(s) of action.

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Section: Resultsmentioning

confidence: 99%

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Kosma

Kapsi

Konstas

et al. 2020

Environmental Research

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show abstract

“…The sampling, pretreatment, and HPLC/MS/MS analysis processes were modified from EPA Method 1694. This is one of the most widely used approaches for analyzing various PPCPs simultaneously (Zhang et al 2020) and can be used to detect 74 main PPCPs and their metabolites/degradation products in seawater. The basic functions and some of their abbreviations are provided in Table S1.…”

Section: Sampling and Preparationmentioning

confidence: 99%

Pharmaceuticals and personal care products in the seawater around a typical subtropical tourist city of China and associated ecological risk

Chen

Guo

et al. 2021

Environ Sci Pollut Res

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“…Various analytical techniques have been reported for AMB titration in both biological and pharmaceutical samples using liquid chromatography , gas chromatography (Yang et al, 2021), chromatography with amperometric detection (Erady et al, 2019), UV spectrophotometry (Yang et al, 2021) and voltammetry (Zhu et al, 2021). In contrast, little is known regarding its environmental behavior, its degradation (Brüggemann et al, 2003), interaction with other environmental media and extraction method from wastewaters (Beckers et al, 2018;Brüggemann et al, 2003;Zhang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…AMB is a biologically recalcitrant substance that for the most part is not degradable in wastewater treatment plants (Zhang et al, 2020). Due to its persistence, it is important to use other treatments to ensure its elimination from water (Beckers et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

High efficiency photocatalytic degradation of Ambroxol over Mn doped TiO2: Experimental designs, identification of transformation products, mineralization and mechanism

Tab

Dahmane

Belabed

et al. 2021

Science of The Total Environment

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Ambroxol (AMB) is a drug commonly used for chronic bronchitis prevention. Once released in surface water, this recalcitrant chemical becomes a hazardous pollutant.Here, we investigated the ability of 1% Mn-doped TiO 2 (Mn-TiO 2 ) to mineralize AMB by photocatalysis. We studied the morphology, and the physical and electrochemical properties of Mn-TiO 2 using X-ray diffraction, Scanning electron microscopy, Transmission electron microscopy, X-ray fluorescence, BET method, UV-visible, and electrochemical study and optimized the AMB degrading experimental conditions through response surface methodology (RSM). Mn-TiO 2 at the dose of 0.625 g.L -1 allowed the complete photodegradation of AMB (30 ppm) at pH 7 under UVA light irradiation for 30 min while total mineralization in CO 2 (> 96%) was achieved after 24 h of irradiation. Mn-TiO 2 was 1.6-time more efficient than TiO 2 Degussa P25. Product studies were also carried out by liquid 2 chromatography coupled to electrospray high resolution mass spectrometry. Twentyone photodegradation products were detected and identified. In addition, ionic chromatography analyses revealed the release of Br -, NH 4 + , and NO 3 at respectively 97, 63 and 35% of the total Br, and N initially present in AMB. Finally, the reusability of the photocatalyst was also tested. After four cycles, the almost complete photodegradation of AMB was achieved showing that Mn-TiO 2 was highly stable.This work brings new physical characteristics on Mn-TiO 2 photocatalyst. Moreover, it is the first study investigating the photocatalytic degradation of recalcitrant AMB drug.

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Efficient multiresidue determination method for 168 pharmaceuticals and metabolites: Optimization and application to raw wastewater, wastewater effluent, and surface water in Beijing, China

Cited by 60 publications

References 50 publications

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Pharmaceuticals and personal care products in the seawater around a typical subtropical tourist city of China and associated ecological risk

High efficiency photocatalytic degradation of Ambroxol over Mn doped TiO2: Experimental designs, identification of transformation products, mineralization and mechanism

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