Efficient micromixing through artificial cilia actuation with fish-schooling configuration

Chen, Chia Yuan; Lin, Cheng Yi; Hu, Ya Ting; Cheng, Lin; Hsu, Chun Chieh

doi:10.1016/j.cej.2014.07.120

Cited by 19 publications

(14 citation statements)

References 26 publications

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“…Fu et al proposed a novel vortex micromixer comprising an injection channel (Y-shaped or Interlaced-shaped), a nozzle structure and a double-heart mixing chamber, and the numerical results were confirmed by performing flow visualization experiments [26]. Chen et al presented a new micromixing strategy that mimics a fish-schooling configuration to design the distribution arrangement of artificial cilia inside a micromixer [27]. In the same year, Yang et al came up with the design, simulation, fabrication and test of a new high-performance micromixer via threedimensional Tesla structures to realize the effective mixing process in the microfluidic devices for bio-applications [28].…”

Section: Introductionmentioning

confidence: 93%

Numerical and experimental investigation on micromixers with serpentine microchannels

Chen

Zeng

et al. 2016

International Journal of Heat and Mass Transfer

228

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Section: Introductionmentioning

confidence: 93%

Numerical and experimental investigation on micromixers with serpentine microchannels

Chen

Zeng

et al. 2016

International Journal of Heat and Mass Transfer

228

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“…For this experiment, the artificial cilia were designed to be actuated in a circular manner which have been observed naturally in the embryonic primary cilia 21 , and mimicked in a microfluidic environment to generate flows as well as well as mixing operation 22 , 23 . To generate such trajectory, a homogeneous magnetic field is indeed necessary.…”

Section: Methodsmentioning

confidence: 99%

Sperm activation through orbital and self-axis revolutions using an artificial cilia embedded serpentine microfluidic platform

Panigrahi

Ghayal

et al. 2018

Sci Rep

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The zebrafish sperm activation profoundly depends upon the homogeneous mixing of the sperm cells with its diluent in a quick succession as it alters the cell’s extracellular medium and initiates their motility. Manual stirring, the traditional method for zebrafish sperm activation is tedious, time-consuming, and has a poor outcome. In this aspect, an artificial cilia embedded serpentine microfluidic is designed through which hydrodynamic factors of the microfluidic environment can be precisely regulated to harness uniform mixing, hence ensuring a superior sperm activation. To quantify the sperm motility, computer assisted sperm analysis software (CASA) was used whereas to quantify the generated flow field, micro particle image velocimetry (μPIV) was used. With this proposed microfluidic, 74.4% of the zebrafish sperm were activated which is 20% higher than its currently existing manual measurements. The μPIV analysis demonstrates that the curvature of the microchannel induces an orbital rotation to the flow field along the length of the microchannel together with the artificial cilia actuation which instigates a local rotation to the flow field of the artificial cilia location. The collective rotation in the whole flow field induce vorticity that promotes the change in temporal dynamics of the sperm cells towards their activation.

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“…Thus, the efficiency in single-phase mixing is limited by the diffusion flux, and dispersion of solutes along the channel is large ( Figure 1 a). Many methods have been introduced to overcome this limitation, such as via Split-and-Recombine [ 8 ], Chaotic flow [ 9 ], and nozzles [ 10 ]. When compared with single phase mixing, droplet-based mixing was put forward to overcome the drawbacks of low mixing efficiency in single-phase and high solutes dispersion because of internal recirculation and isolated environments [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Passive Mixing inside Microdroplets

et al. 2018

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Droplet-based micromixers are essential units in many microfluidic devices for widespread applications, such as diagnostics and synthesis. The mixers can be either passive or active. When compared to active methods, the passive mixer is widely used because it does not require extra energy input apart from the pump drive. In recent years, several passive droplet-based mixers were developed, where mixing was characterized by both experiments and simulation. A unified physical understanding of both experimental processes and simulation models is beneficial for effectively developing new and efficient mixing techniques. This review covers the state-of-the-art passive droplet-based micromixers in microfluidics, which mainly focuses on three aspects: (1) Mixing parameters and analysis method; (2) Typical mixing element designs and the mixing characters in experiments; and, (3) Comprehensive introduction of numerical models used in microfluidic flow and diffusion.

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Efficient micromixing through artificial cilia actuation with fish-schooling configuration

Cited by 19 publications

References 26 publications

Numerical and experimental investigation on micromixers with serpentine microchannels

Numerical and experimental investigation on micromixers with serpentine microchannels

Sperm activation through orbital and self-axis revolutions using an artificial cilia embedded serpentine microfluidic platform

Passive Mixing inside Microdroplets

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