Efficient Improvements of Herpex Simplex Labialis Treatment Using Diode Laser and “Tebodont” Gel

Abstract

The introduction of laser systems into the dental practice takes an important place in the development of methods for accelerated and effective treatment of viral diseases. As a matter of fact, laser radiation blocks the inflammatory process, suppresses the pathogenicity of the virus, improves the processes of microcirculation. The use of tea tree oil-based preparations promotes regeneration and restoration of the tunica mucosa of mouth.
 The aim of this study is to assess the therapeutic efficacy of combined use of laser radiation with “Tebodont” gel based on tea tree oil in the treatment of recurrent Herpes simplex Labialis. Clinical observation of 44 patients was conducted on the basis of Pyrohov Memorial Vinnytsia National Medical University at the age from 17 to 22 years old. Among them there were 26 women and 18 men with a prolonged history of the disease within 6 years or more: light severity. Diagnosis of the disease was performed on the basis of complaints of patients, results of objective examination and molecular-biological method of polymerase chain reaction (PCR).
 To assess the treatment efficiency, patients were divided into three levels according to the number of group: I, II and control. All patients were prescribed a commonly agreed treatment regimen, which included the local application of antiviral “Herpevir” ointment for the first 3 days, anaesthetic gel “Kamistad”, and keratoplastic agents to stimulate the epithelization. Patients of I group, with the exception of “Herpevir” ointment, during the first 3 days of the disease received a daily two-time application of “Tebodont” gel on the affected lip area until the final epithelization.
 Patients of II main group underwent laser contactless irradiation of the affected lip area with diode laser Picasso made by the company “AMD Lasers” (USA) in a continuous mode with the power range of 0.5 Watt using non-activated fibre and “Program 4”. Exposition – 2 minutes on the area, number – 5 procedures and daily two-time application of “Tebodont” gel on the affected lip area until the final epithelization.
 The efficiency was being assessed within two weeks from the starting date of treatment based on subjective data and clinical examination results. Patients of I main group began to recover on 3-4 days of examination. Full epithelization of the affected area occurred on the 5-6 days of treatment. All patients of II main group showed an improvement in the clinical picture already on the second day after the treatment. They noted a decrease in pain, edema, and hyperaemia. Complete epithelization of erosive defects in patients was observed on the 3-4 days of the examination. Patients of the control group noted an improvement in the clinical picture of the disease – decrease of discomfort, pain, only on the fifth day of treatment. Initial manifestations of epithelization of the affected area were observed in the patients of this group only on the 7-8 days. High efficiency of treatment in the main groups was observed already on the 5th day of treatment and constituted 100% in II and 79% in the I group. In the control group, complete healing occurred only on the 10-12 days of treatment.
 Obtained results of the study certify that the use of laser radiation in combination with tea tree oil-based “Tebodont” gel in the treatment of recurrent Herpes simplex Labialis, in terms of therapeutic efficiency, exceeds conventional medical treatment.
 The prospect of further research is to develop and introduce modern methods for the treatment of diseases of the tunica mucosa of mouth into the dental practice with the usage of laser radiation and preparations based on tea tree oil.