Efficientin vivogene transfection by stable DNA/PEI complexes coated by hyaluronic acid

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

“…36 Previous studies have demonstrated that HA-based nanoparticles showed high cell uptake efficiency by receptor-mediated active targeting mechanism. 14,15,37 In this study, the intracellular distribution of HRA nanoparticles in MCF-7 cells was monitored by confocal laser scanning microscopy. The coumarin-6, as a fluorescent marker, was encapsulated into HRA nanoparticles.…”

“…13,14 Many HA derivatives have been developed for tumor-targeting delivery of chemical and genetic drugs. 15,16 These HA-based nanoparticles exhibited significantly enhanced targeting efficiency to the tumor and higher therapeutic efficacy due to the HA-mediated endocytosis. Some studies indicate that HA exhibits strong anticancer activity by inhibiting the metastasis and growth of cancer cells.…”

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

“…Hyaluronic acid is widely distributed in extracellular matrix and the joint liquid of mammals and approved for injections by the Food and Drug Administration (FDA) [85]. It is a biocompatible mucoadhesive polysaccharide with negative charge and is biodegradable.…”

γ-Polyglutamic acid-coated vectors for effective and safe gene therapy

“…Recharging cationic complexes with anionic compound was reported to be a promising method for overcoming these adverse effects [10,11]. In a previous study, we discovered an anionic coating, γ-polyglutamic acid (γ-PGA), which decreased the toxicities of cationic complexes without reductions of efficacies [12].…”