Efficient delivery of paclitaxel into ASGPR over-expressed cancer cells using reversibly stabilized multifunctional pullulan nanoparticles

Huang, Liping; Wang, Yutong; Ling, Xiang; Chaurasiya, Birendra; Yang, Chen; Du, Yunai; Tu, Jiasheng; Xiong, Yerong; Sun, Chong

doi:10.1016/j.carbpol.2016.11.094

Cited by 33 publications

(14 citation statements)

References 60 publications

(60 reference statements)

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“…Pharmacokinetic analysis was performed by means of a noncompartmental method using DAS 2.1.1 soware (Mathematical Pharmacology Professional Committee of China, China). 40 The pharmacokinetic parameters including maximum plasma concentration (C max ) and the time to reach maximum plasma concentration (T max ) were directly obtained from plasma data. The area under the plasma concentration-time curves (AUC 0-t ) was calculated using the trapezoidal method.…”

Section: Pharmacokinetic Studiesmentioning

confidence: 99%

Preparation and evaluation of celecoxib nanosuspensions for bioavailability enhancement

Han

et al. 2017

RSC Adv.

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Section: Pharmacokinetic Studiesmentioning

confidence: 99%

Preparation and evaluation of celecoxib nanosuspensions for bioavailability enhancement

Han

et al. 2017

RSC Adv.

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“…Paclitaxel (PTX), a highly hydrophobic diterpenoid, is also one of the most widely used anti‐cancer drug for treating various tumors, such as OSCC, prostate, breast, ovarian, lung, bladder, liver and others . However, compared to DDP, the disadvantages of PTX have hampered its clinical applications, which include poor water solubility (<0.03 mg/ml aqueous solubility) and low oral bioavailability . Therefore, DDP was chosen as a positive control group.…”

Section: Discussionmentioning

confidence: 99%

“…43 However, compared to DDP, the disadvantages of PTX have hampered its clinical applications, which include poor water solubility (<0.03 mg/ ml aqueous solubility) and low oral bioavailability. 44 Therefore, DDP was chosen as a positive control group. The nontoxic effect of VB is of particular interest.…”

Section: Discussionmentioning

confidence: 99%

Effect of verbascoside on apoptosis and metastasis in human oral squamous cell carcinoma

Zhang

Yuan

et al. 2018

Intl Journal of Cancer

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Despite significant advances in therapy, the 5-year survival rates for patients with advanced stage oral cancers still remains poor as an appropriate treatment has not been found yet, due to side effects of chemo/radiotherapy. Verbascoside (VB), a major bioactive constituent of the Tsoong herb, displays pharmacological properties by exhibiting anti-oxidative, anti-inflammatory and anti-cancer activities. However, the underlining function and mechanism of VB in human oral squamous cell carcinoma (OSCC) remains unclear. In this study, we show that VB significantly decreased the viability and metastasis of HN4 and HN6 tumor cells, while promoting apoptosis. A xenograft OSCC mouse model further showed that intraperitoneal injection of VB strongly inhibited growth and lung metastasis of implanted tumor cells. Immunoblot analysis confirmed that VB effectively suppressed nuclear factor (NF)-κB activation and downstream Bcl-2/Bcl-XL expression, resulting in increased OSCC cell apoptosis. In addition, VB suppressed mRNA and protein expression of matrix metalloproteinase-9 via suppression of NF-κB activation, thereby inhibiting tumor cell metastasis. Inspiringly, compared to cisplatin-treated group, VB is a biocompatible agent without signficant side effects in vivo. Collectively, our results demonstrate that VB effectively inhibits OSCC tumor cell growth and metastasis via suppression of IκB kinase complex (IKK)/NF-κB-related signaling activation, suggesting that VB has potential use as a potent anticancer agent in OSCC therapeutic strategies.

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“…Initial clinical phase I trials found conjugates of a tri-GalNAc construct with antisense oligonucleotides to be highly potent and with a high margin of safety [67,68]. Ligand structures based on peptides, Gal or pullulan (a polysaccharide consisting of maltotriose units) were developed to deliver chemotherapeutic drugs such as doxorubicin and paclitaxel to treat hepatic cancers [69][70][71]. Complex structures in which GalNAc is attached to the tyrosine hydroxyl oxygen of proteins or peptides also express a K D in the nanomolar range [72].…”

Section: Asgr1mentioning

confidence: 99%

ASGR1 and Its Enigmatic Relative, CLEC10A

Hoober

2020

IJMS

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The large family of C-type lectin (CLEC) receptors comprises carbohydrate-binding proteins that require Ca2+ to bind a ligand. The prototypic receptor is the asialoglycoprotein receptor-1 (ASGR1, CLEC4H1) that is expressed primarily by hepatocytes. The early work on ASGR1, which is highly specific for N-acetylgalactosamine (GalNAc), established the foundation for understanding the overall function of CLEC receptors. Cells of the immune system generally express more than one CLEC receptor that serve diverse functions such as pathogen-recognition, initiation of cellular signaling, cellular adhesion, glycoprotein turnover, inflammation and immune responses. The receptor CLEC10A (C-type lectin domain family 10 member A, CD301; also called the macrophage galactose-type lectin, MGL) contains a carbohydrate-recognition domain (CRD) that is homologous to the CRD of ASGR1, and thus, is also specific for GalNAc. CLEC10A is most highly expressed on immature DCs, monocyte-derived DCs, and alternatively activated macrophages (subtype M2a) as well as oocytes and progenitor cells at several stages of embryonic development. This receptor is involved in initiation of TH1, TH2, and TH17 immune responses and induction of tolerance in naïve T cells. Ligand-mediated endocytosis of CLEC receptors initiates a Ca2+ signal that interestingly has different outcomes depending on ligand properties, concentration, and frequency of administration. This review summarizes studies that have been carried out on these receptors.

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Efficient delivery of paclitaxel into ASGPR over-expressed cancer cells using reversibly stabilized multifunctional pullulan nanoparticles

Cited by 33 publications

References 60 publications

Preparation and evaluation of celecoxib nanosuspensions for bioavailability enhancement

Preparation and evaluation of celecoxib nanosuspensions for bioavailability enhancement

Effect of verbascoside on apoptosis and metastasis in human oral squamous cell carcinoma

ASGR1 and Its Enigmatic Relative, CLEC10A

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