Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative.

Matsushita, Sayaka; Yanai, Yoshihiro; Fusyuku, Asami; Fujiwara, Yukio; Ikeda, Tsuyoshi; Ono, M.; Han, Chong; Ojika, Makoto; Nohara, Toshihiro

doi:10.1002/chin.200750196

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2008

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“…Tomatidine may benefit cancer chemotherapy by inhibiting multidrug resistance in human cancer cells [19] and by inhibiting the growth of colon and liver cancer cells [20]. Tomatidine was developed into a pregnane derivative possessing neuritogenic and NGF‐enhancing activities [21]. In addition, tomatidine suppresses the oxidative burst and is able to suppress induced plant defense responses [22,23].…”

Section: Discussionmentioning

confidence: 99%

Tomatidine inhibits iNOS and COX‐2 through suppression of NF‐κB and JNK pathways in LPS‐stimulated mouse macrophages

2008

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We use the LPS-stimulated macrophage as a model of inflammation to investigate the anti-inflammatory effects of tomatidine and solasodine, whose structures resemble glucocorticoids. We found that tomatidine exhibited a more potent antiinflammatory effect than solasodine. Tomatidine could decrease inducible nitric oxide synthase and cyclooxygenase-2 expression through suppression of I-jBa phosphorylation, NF-jB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Here, we demonstrate that tomatidine acts as an anti-inflammatory agent by blocking NF-jB and JNK signaling, and may possibly be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%