Efficient batch-mode mixing and flow patterns in a microfluidic centrifugal platform: a numerical and experimental study

Mortazavi, Sayyed Mohammad Ali; Tirandazi, Pooyan; Normandie, M.; Saidi, Mohammad R.

doi:10.1007/s00542-016-3109-7

Cited by 8 publications

(11 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent advances in microfluidics have contributed significantly to 3D spheroid research by addressing the aforementioned limitations [59,60]. The significant advantages of microfluidic systems include providing controlled mixing [61], chemical concentration gradients, lower reagent consumption, continuous perfusion and precise control of pressure and shear stress on cells [62]. A remarkable feature of microfluidic chips is that cells can be cultured in a dynamic microenvironment to better recapitulate the tissue environment.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

Moshksayan

Kashaninejad

Warkiani

et al. 2018

Sensors and Actuators B: Chemical

Self Cite

210

175

View full text Add to dashboard Cite

Highlights  Cell spheroids are spherical aggregates best mimicking the tissue microenvironment.  Spheroid culture better recapitulates the in-vivo condition in microfluidic chips.  Microfluidics provides rapid spheroid formation with size uniformity and control.  These chips contain microwells, microstructures, droplet generators, etc.  To fabricate such chips, some design considerations must be taken into account.

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

Moshksayan

Kashaninejad

Warkiani

et al. 2018

Sensors and Actuators B: Chemical

Self Cite

210

175

View full text Add to dashboard Cite

show abstract

“…Mortazavi et al (2017) also investigated the mixing by acceleration and deceleration of a rotational unit, and explored this both computationally and experimentally. 32 They used the finite volume method to solve the Navier-Stokes, the continuity, and the convection-diffusion equations. The simulations showed, as expected, the generation of a principal vortex in the horizontal transverse section of the chamber, and two Dean vortices through a vertical cross-section.…”

Section: Mixing In Single-phase Flowsmentioning

confidence: 99%

“…29 Reprinted with permission from Elsevier. (C) The geometry of four different designs considered for batch-mode mixing by Mortazavi et al 32 Reprinted by permission from Springer Nature. (D) The standard deviation of species concentration over time for the most desirable design.…”

Section: Mixing In Single-phase Flowsmentioning

confidence: 99%

See 1 more Smart Citation

Mathematical modeling and computational analysis of centrifugal microfluidic platforms: a review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Sample mixing, or homogenization, is an essential step in most biological and chemical processes. 1,[3][4][5][6] However, mixing on a microuidic CD is a challenging task due to the high articial gravity generated by centrifugal force, which is ideal for separation but not mixing.…”

Section: 2mentioning

confidence: 99%

New generation of spinning systems for robust active mixing on microfluidic CDs: oil/water emulsion as an evaluation test

et al. 2018

View full text Add to dashboard Cite

Microfluidic CDs (or Lab-on-Disc) continue to emerge in various applications of real life sciences, including biomedical and pharmaceutical fields. However, microfluidic CDs with advanced and efficient unit operation tools, such as pumping, valving, and mixing, need to be implemented to achieve the required applications in these fields. In this work, a novel generation of a spinning system to perform robust active mixing is developed for microfluidic CDs. The developed system is equipped with a dual-motor and dual-CD configuration to perform magnetically driven active mixing. The results show that the developed spinning system can provide a wide range of mixing frequencies independent of the spinning speed of the microfluidic CD. To evaluate the performance of this system under extreme conditions, an emulsion process of oil and water was conducted. Although the oil produced high drag force on the mixing magnet, the emulsion process successfully reached a steady state of mixing within a few seconds (approximately 3.5 s), and the mixture became homogeneous at 75 seconds. To demonstrate one of the potential applications of the proposed developed spinning setup, microparticles were successfully extracted from water to oil using water/oil emulsion on the microfluidic CD. In conclusion, mixing can be performed without influencing the integrated microfluidic components such as valves or pumps. This improvement can widen the range of applicability of microfluidic CDs in multi-step and complex processes where mixing is essential.

show abstract

Efficient batch-mode mixing and flow patterns in a microfluidic centrifugal platform: a numerical and experimental study

Cited by 8 publications

References 27 publications

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

Mathematical modeling and computational analysis of centrifugal microfluidic platforms: a review

New generation of spinning systems for robust active mixing on microfluidic CDs: oil/water emulsion as an evaluation test

Contact Info

Product

Resources

About