Efficient antibacterial dextran-montmorillonite composite sponge for rapid hemostasis with wound healing

Liu, Chunyu; Liu, Chenyu; Yu, Simiao; Wang, Ning; Yao, Weihe; Liu, Xia; Sun, Guozhen; Song, Qiling; Qiao, Weihong

doi:10.1016/j.ijbiomac.2020.05.140

Cited by 47 publications

(17 citation statements)

References 40 publications

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“…In trauma caused by accidences and surgery, certain amounts of bleeding are to be expected, so hemostasis is required for wound treatment [ 49 ]. The ideal wound dressing should have the ability to clot blood to accelerate hemostasis [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment

et al. 2023

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Background Post-traumatic massive hemorrhage demands immediately available first-aid supplies with reduced operation time and good surgical compliance. In-situ crosslinking gels that are flexibly adapting to the wound shape have a promising potential, but it is still hard to achieve fast gelation, on-demand adhesion, and wide feasibility at the same time. Methods A white-light crosslinkable natural milk-derived casein hydrogel bioadhesive is presented for the first time. Benefiting from abundant tyrosine residues, casein hydrogel bioadhesive was synthesized by forming di-tyrosine bonds under white light with a ruthenium-based catalyst. We firstly optimized the concentration of proteins and initiators to achieve faster gelation and higher mechanical strength. Then, we examined the degradation, cytotoxicity, tissue adhesion, hemostasis, and wound healing ability of the casein hydrogels to study their potential to be used as bioadhesives. Result Rapid gelation of casein hydrogel is initiated with an outdoor flashlight, a cellphone flashlight, or an endoscopy lamp, which facilitates its usage during first-aid and minimally invasive operations. The rapid gelation enables 3D printing of the casein hydrogel and excellent hemostasis even during liver hemorrhage due to section injury. The covalent binding between casein and tissue enables robust adhesion which can withstand more than 180 mmHg blood pressure. Moreover, the casein-based hydrogel can facilitate post-traumatic wound healing caused by trauma due to its biocompatibility. Conclusion Casein-based bioadhesives developed in this study pave a way for broad and practical application in emergency wound management.

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Section: Discussionmentioning

confidence: 99%

White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment

et al. 2023

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“…In terms of consumption volume, the most important areas of bentonite clay application in Russia are metallurgy, agriculture and medicine [13,14]. The empirical use of clays has often led to a good wound healing effect [16]. By now, both individual samples and their modified forms are studied.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial Activity Of Layered Silicate Materials

et al. 2021

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Objective — to assess the presence of a direct antimicrobial effect of natural minerals (ammonite; montmorillonite of the Azerbaijani deposit; calcium montmorillonite, or light clay, and sodium montmorillonite, or dark clay, of the Gerpegezh deposit in Kabardino-Balkaria; serpentinite) against strains of Staphylococcus aureus, Escherichia coli and yeast-like Candida fungi. Material and Methods — The antimicrobial activity was investigated by qualitative and quantitative methods; the methods of X-ray diffraction and X-ray fluorescence analysis were used to assess the chemical composition of samples of natural minerals. The results were statistically processed. Results — We established that ammonite, montmorillonite of Azerbaijani origin and serpentinite did not have a direct antimicrobial effect against the studied cultures of bacteria and fungi (S. aureus, E. coli, Candida albicans). The growth of S. aureus was suppressed by calcium and sodium montmorillonite from the Gerpegezh deposit. Sodium montmorillonite had the strongest antibacterial effect, and its dose-dependent effect was revealed. According to the data of X-ray fluorescence analysis, in the structure of, trivalent iron and oxides of manganese and titanium predominated in the samples of dark Gerpegezh clay with a more pronounced anti-staphylococcal effect. Conclusion — Our study demonstrated the possibilities and limitations of using various samples of layered silicate minerals for antibacterial solutions. The spectrum of antimicrobial activity largely depends on the unique composition of mineral complexes. Samples with a high content of iron(III) can be considered promising in the development of natural antimicrobial preparations.

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“…This modification improved the mechanical strength and stability of the hydrogels by significantly increasing the degree of crosslinking, which formed a dense intermolecular network. Most recently, Liu et al [ 89 ] developed poly aldehyde dextran sponges loaded with montmorillonite powder (a natural silicate) for hemorrhage control. Their results suggest that their dextran-based hemostatic sponge exhibited good tissue adhesion, antibacterial activity against Escherichia coli and improved wound healing as well.…”

Section: Polysaccharide Materials For Hemostasismentioning

confidence: 99%

Recent advances in biopolymer-based hemostatic materials

Mecwan

Falcone

et al. 2022

Regenerative Biomaterials

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Hemorrhage is the leading cause of trauma-related deaths, in hospital and pre-hospital settings. Hemostasis is a complex mechanism that involves a cascade of clotting factors and proteins that result in the formation of a strong clot. In certain surgical and emergency situations, hemostatic agents are needed to achieve faster blood coagulation to prevent the patient from experiencing a severe hemorrhagic shock. Therefore, it is critical to consider appropriate materials and designs for hemostatic agents. Many materials have been fabricated as hemostatic agents, including synthetic and naturally derived polymers. However, compared to synthetic polymers, natural polymers or biopolymers, which include polysaccharides and polypeptides, have greater biocompatibility, biodegradability, and processibility. Thus, in this review, we focus on biopolymer-based hemostatic agents of different forms, such as powder, particles, sponges, and hydrogels. Finally, we discuss biopolymer-based hemostats currently in clinical trials and offer insight into next-generation hemostats for clinical translation.

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Efficient antibacterial dextran-montmorillonite composite sponge for rapid hemostasis with wound healing

Cited by 47 publications

References 40 publications

White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment

White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment

In Vitro Antimicrobial Activity Of Layered Silicate Materials

Recent advances in biopolymer-based hemostatic materials

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