Efficient and selective separation of metronidazole from human serum by using molecularly imprinted magnetic nanoparticles

Abstract

Magnetic molecularly imprinted nanoparticles were prepared through surface-initiated reversible addition fragmentation chain transfer polymerization by using metronidazole as a template. The molecularly imprinted magnetic nanoparticles were characterized by attenuated total reflection Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, X-ray diffraction and vibrating sample magnetometry. The adsorption characteristics were also investigated and the kinetics of the adsorption of metronidazole on the imprinted nanoparticles were described by the second-order kinetic model with the short equilibrium adsorption time (30 min). The adsorption isotherm was well matched with the Langmuir isotherm in which the maximum adsorption capacity was calculated to be 40.1 mg/g. Furthermore, the imprinted magnetic nanoparticles showed good selectivity as well as reusability even after six adsorption-desorption cycles. The imprinted magnetic nanoparticles were used as a sorbent for the selective separation of metronidazole from human serum. The recoveries of metronidazole from human serum changed between 97.5-99.8% and showed similar sensitivity as compared with an enzyme-linked immunoassay method. Therefore, the molecularly imprinted magnetic nanoparticles might have potential application for the selective and reliable separation of metronidazole from biological fluids in clinical applications. This article is protected by copyright. All rights reserved.

Synthesis of copper–nitrogen codoped carbon quantum dots using frangipani as a carbon source and application of metronidazole determination

“…However, studies have shown that metronidazole has teratogenic effects on animal and plant cells, including carcinogenic and mutagenic effects. If used irrationally or abused in livestock and poultry feed, metronidazole residues may persist in animal tissue and could be transmitted through the food chain, thereby indirectly causing damage to the human body, such as epileptic neuropathy [4,5]. As is well known, the abuse of antibiotics, release of antibiotics into the environment, and development of drug-resistant genes in natural ecosystems are increasingly serious global threats.…”

Synthesis, characterization, and evaluation of selective molecularly imprinted polymers for the fast determination of synthetic cathinones

“…Molecular imprinting is known as an efficient technique for the creation of synthetic specic recognition sites in a polymeric network with a memory of the shape, size and functional group of the template molecules. 16,17 With these superior features, MIPs are widely used for applications including sensing, 18 solid phase extraction, 19 antibody detection, 20 separation and purication technology, 21 food analysis 22 and pharmaceutical analysis. 23 The synthesis methods of MIPs are quite simple and mature such as bulk polymerization, 24 precipitation polymerization, 25 membrane polymerization, 26 electropolymerization, 27,28 multi-step swelling and polymerization and surface-graing polymerization.…”

Surface modified‐magnetic nanoparticles by molecular imprinting for the dispersive solid‐phase extraction of triazines from environmental waters

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