Efficient and Green Synthesis of Bis(indolyl)Methanes using Thiamine Hydrochloride as an Organocatalyst: A Parallel Scrutiny of Microwave Irradiation versus Ultrasonicator Heating in Water

Abstract

: Thiamine hydrochloride is reported to be highly competent promoter for the synthesis of bis(indolyl)methanes under solvent free conditions using microwave irradiation and ultrasonicator heating in aqueous media. Vitamin B1 is an economical, non-toxic, nonflammable and water soluble green organocatalyst. Moreover, the simple approach, easily operational, short reaction time, high yield and using a little quantity of thiamine hydrochloride makes this method an alternative approach. Present protocol is a simple and eco-friendly approach for the synthesis of bis(indolyl)methanes under microwave and ultrasonicator condition.

Recent Advances of Thiamine in Organic Synthesis

“…Afterwards, Thorat et al elaborated the synthesis of bis(indolyl)methanes under microwave irradiation and solvent-free conditions using VB 1 as catalyst. [22] The above protocol requires less reaction times as compared to the method without microwave irradiation. In all cases, the reactions were completed within 10 min to give the corresponding BIMs products in good to excellent yields, which would make it an ideal choice for an eco-friendly synthetic strategy.…”

“…Afterwards, Thorat et al. elaborated the synthesis of bis(indolyl)methanes under microwave irradiation and solvent‐free conditions using VB 1 as catalyst [22] . The above protocol requires less reaction times as compared to the method without microwave irradiation.…”