Efficient and facile strategy to substituted 2-aminothiazoles via ring opening of α-nitroepoxides

Catalyst-Free Synthesis of Benzofuran Derivatives from Cascade Reactions between Nitroepoxides and Salicylaldehydes

“…This bifunctional capability of these structures makes them the right choice for performing complex multicomponent reactions . Noticeably, the use of bifunctional nucleophiles in the reaction with α-nitroepoxides has been employed for the synthesis of critical heterocyclic structures. − In agreement with this, the syntheses of pyrroles, cyclic thioureas, thiazoles, and quinoxalines have been successfully performed starting from α-nitroepoxides.…”

NH4I-promoted electrosynthesis of 2-aminothiazole derivatives from ketone compounds and NH4SCN

“…This unstable intermediate D could be quickly converted to the stable target product 2a via an intramolecular nucleophilic addition reaction and isomerization process. 5 At the cathode, NH 4 + ions are reduced to produce H 2 and NH 3 . In fact, the exact reaction mechanism needs to be studied further.…”

“…4 Recently, Yu's research group developed an efficient and facile strategy to synthesize substituted 2-aminothiazoles via ring opening of α -nitroepoxides (Scheme 2c). 5 However, there are some drawbacks in these synthetic routes, such as multi-step reactions or expensive substrates. Therefore, it is still very necessary to develop an efficient and environmentally friendly method to synthesize 2-aminothiazole derivatives.…”