Efficient and Chemoselective Amidation of β‐Carboline Carboxylic Acids

Abstract

A series of β‐carboline amides has been synthesized in one‐pot reaction via coupling between an acid and an amine in the presence of HBTU/Et3N. This mild amidation reaction undergoes efficiently and chemoselectively. Bioactivity studies indicate that the β‐carboline amide derivatives exhibit neuroprotective activity and might be developed to be lead compounds for anti‐stroke agents.